{"id":25,"date":"2017-08-31T10:00:37","date_gmt":"2017-08-31T07:00:37","guid":{"rendered":"http:\/\/icg.nsc.ru\/encephalitis\/?page_id=25"},"modified":"2017-08-31T10:00:37","modified_gmt":"2017-08-31T07:00:37","slug":"up-down-regulated","status":"publish","type":"page","link":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/up-down-regulated\/","title":{"rendered":"Genes encoding mRNAs (or proteins) that were up- or down-regulated in response to TBEV infection"},"content":{"rendered":"

All genes were collected from the research papers.
\nIf the publication described a non-human mammalian gene\/protein, the homologous human gene was found and included into the catalog.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
EntrezGene
\nOfficial
\nSymbol<\/th>\n		Official Full Name<\/th>\nEntrezGene
\nGene ID<\/th>\n		Also
\nknown as<\/th>\n		References<\/th>\nPMID<\/th>\nVirus, strain<\/th>\nInductor
\n(TBEV or protein)<\/th>\n		Host
\norganism<\/th>\n		mRNA
\nexpression
\nlevel
\nor protein
\nexpression
\nlevel<\/th>\n		Effect<\/th>\nMethod in vivo\/invitro<\/th>\n<\/tr>\n
A2M<\/a><\/em><\/td>\nalpha-2-macroglobulin<\/td>\n2<\/a><\/td>\n<\/td>\n[Merzeniuk ZA et al., 2000]<\/td>\n10925884<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, liquor from patients with the meningeal and focal forms of tick-borne encephalitis [Merzeniuk ZA et al., 2000]<\/td>\n<\/tr>\n
ATF6<\/em><\/td>\nactivating transcription factor 6<\/td>\n22926<\/a><\/td>\n<\/td>\n[Yu C. et al., 2013]<\/td>\n24177270<\/a><\/td>\nTBEV (strain K23)<\/td>\nTBEV<\/td>\nAfrican Green\u00a0 Monkey<\/td>\nprotein (cleaved form)<\/td>\nExpression was upregulated<\/td>\nin vitro,\u00a0 Vero E6 (Monkey African Green kidney A subclone of Vero76) cells,\u00a0 A552 [Yu C. et al., 2013]<\/td>\n<\/tr>\n
BCL2<\/em><\/td>\nBCL2, apoptosis regulator<\/td>\n596<\/a><\/td>\n<\/td>\n[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vivo, human NK cells in response to\u00a0TBEV\u00a0infection [Blom K et al., 2016]<\/td>\n<\/tr>\n
[Blom K et al., 2015]<\/td>\n25611738<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vivo,\u00a0 CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]<\/td>\n<\/tr>\n
CCL2<\/em><\/td>\nC-C motif chemokine ligand 2<\/td>\n6347<\/a><\/td>\nMCP-1\/CCL2, monocyte chemoattractant protein<\/td>\n[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
CCL3<\/em><\/td>\nC-C motif chemokine ligand 3<\/td>\n6348<\/a><\/td>\nMIP-1\u03b1, MIP-1a, macrophage inflammatory protein 1\u03b1<\/td>\n[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
CCL4<\/em><\/td>\nC-C motif chemokine ligand 4<\/td>\n6351<\/a><\/td>\nMIP-1b\/CCL-4, MIP-1beta, MIP-1b<\/td>\n[Palus M et al., 2014a]<\/td>\n25000960<\/a><\/td>\nTBEV (strain Neudoerfl)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td>\n<\/tr>\n
[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
CCL5<\/em><\/td>\nC-C motif chemokine ligand 5<\/td>\n6352<\/a><\/td>\nRANTES<\/td>\n[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
[Zhang X et al., 2016]<\/td>\n27576490<\/a><\/td>\nTBEV, Far Eastern strain<\/td>\nTBEV<\/td>\nMouse, Human<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo: mouse, in vitro: human brain-derived cell lines and primary progenitor-derived astrocytes [Zhang X et al., 2016]<\/td>\n<\/tr>\n
[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
CD27<\/em><\/td>\nCD27\u00a0molecule<\/td>\n939<\/a><\/td>\n<\/td>\n[Blom K et al., 2015]<\/td>\n25611738<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td>\n<\/tr>\n
CD3E<\/em><\/td>\nCD3e molecule<\/td>\n916<\/a><\/td>\nCD3<\/td>\n[Fujii Y et al., 2011]<\/td>\n21830901<\/a><\/td>\nTBEV Oshima 5-10 strain<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
CD4<\/em><\/td>\nCD4 molecule<\/td>\n920<\/a><\/td>\n<\/td>\n[Fujii Y et al., 2011]<\/td>\n21830901<\/a><\/td>\nTBEV Oshima 5-10 strain<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
CD40<\/em><\/td>\nCD40 molecule<\/td>\n958<\/a><\/td>\n<\/td>\n[Zajkowska JM al.,\u00a0 2006]<\/td>\n16463218<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, CSF [Zajkowska JM al.,\u00a0 2006]<\/td>\n<\/tr>\n
CD40LG<\/em><\/td>\nCD40 ligand<\/td>\n959<\/a><\/td>\nCD40L<\/td>\n[Zajkowska JM al.,\u00a0 2006]<\/td>\n16463218<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo,\u00a0 serum [Zajkowska JM al.,\u00a0 2005]<\/td>\n<\/tr>\n
[Zajkowska JM al.,\u00a0 2006]<\/td>\n16463218<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, CSF [Zajkowska JM al.,\u00a0 2006]<\/td>\n<\/tr>\n
CD69<\/em><\/td>\nCD69 molecule<\/td>\n969<\/a><\/td>\n<\/td>\n[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Dal\u2019negorsk strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vitro, monocytes, NK cells [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Dal\u2019negorsk strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vitro, CD8 T-lymphocytes [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Primorye-183 strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vitro, monocytes, granulocytes [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Primorye-183 strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vitro, NK cells, CD8 + Tlymphocytes, and CD4 + T-lymphocytes [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
[Fujii Y et al., 2011]<\/td>\n21830901<\/a><\/td>\nTBEV Oshima 5-10 strain<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
CD8A<\/em><\/td>\nCD8a molecule<\/td>\n925<\/a><\/td>\nCD8<\/td>\n[Fujii Y et al., 2011]<\/td>\n21830901<\/a><\/td>\nTBEV Oshima 5-10 strain<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
CXCL10<\/em><\/td>\nC-X-C motif chemokine ligand 10<\/td>\n3627<\/a><\/td>\nIP-10\/CXCL10, IP-10, interferon \u03b3-induced protein 10,\u00a0 IFN-\u03b3-induced protein 10<\/td>\n[Palus M et al., 2014a]<\/td>\n25000960<\/a><\/td>\nTBEV (strain Neudoerfl)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td>\n<\/tr>\n
[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
[Zajkowska J et al., 2011]<\/td>\n22008312<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, serum, CSF [Zajkowska J et al., 2011]<\/td>\n<\/tr>\n
[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
CXCL11<\/em><\/td>\nC-X-C motif chemokine ligand 11<\/td>\n6373<\/a><\/td>\nI-TAC<\/td>\n[Zajkowska J et al., 2011]<\/td>\n22008312<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, CSF [Zajkowska J et al., 2011]<\/td>\n<\/tr>\n
CXCL12<\/em><\/td>\nC-X-C motif chemokine ligand 12<\/td>\n6387<\/a><\/td>\nSDF-1\u03b1<\/td>\n[Zajkowska J et al., 2011]<\/td>\n22008312<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, CSF [Zajkowska J et al., 2011]<\/td>\n<\/tr>\n
CXCL13<\/em><\/td>\nC-X-C motif chemokine ligand 13<\/td>\n10563<\/a><\/td>\nBLC\/BCA-1<\/td>\n[Zajkowska J et al., 2011]<\/td>\n22008312<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, serum, CSF [Zajkowska J et al., 2011]<\/td>\n<\/tr>\n
CXCL8<\/em><\/td>\nC-X-C motif chemokine ligand 8<\/td>\n3576<\/a><\/td>\nIL-8<\/td>\n[Palus M et al., 2014a]<\/td>\n25000960<\/a><\/td>\nTBEV (strain Neudoerfl)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td>\n<\/tr>\n
[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo,\u00a0 plasma [Blom K et al., 2016]<\/td>\n<\/tr>\n
DDX58<\/em><\/td>\nDExD\/H-box helicase 58<\/td>\n23586<\/a><\/td>\nRIG-I<\/td>\n[Zhang X et al., 2016]<\/td>\n27576490<\/a><\/td>\nTBEV, Far Eastern strain<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vitro: Human\u00a0 T98G cells [Zhang X et al., 2016]<\/td>\n<\/tr>\n
EOMES<\/em><\/td>\neomesodermin<\/td>\n8320<\/a><\/td>\n<\/td>\n[Blom K et al., 2015]<\/td>\n25611738<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td>\n<\/tr>\n
FAS<\/em><\/td>\nFas cell surface death receptor<\/td>\n355<\/a><\/td>\nCD95<\/td>\n[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Dal\u2019negorsk strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vitro, NK cells [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Primorye-183 strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vitro, NK cells [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
FASLG<\/em><\/td>\nFas ligand<\/td>\n356<\/a><\/td>\nFasL<\/td>\n[Fujii Y et al., 2011]<\/td>\n21830901<\/a><\/td>\nTBEV Oshima 5-10 strain<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
G3BP1<\/em><\/td>\nG3BP stress granule assembly factor 1<\/td>\n10146<\/a><\/td>\n<\/td>\n[Albornoz A et al., 2014]<\/td>\n24696465<\/a><\/td>\nTBEV strain Neudoerfl<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vitro, human U2OS cells [Albornoz A et al., 2014]<\/td>\n<\/tr>\n
GFAP<\/em><\/td>\nglial fibrillary acidic protein<\/td>\n2670<\/a><\/td>\n<\/td>\n[Palus M et al., 2014a]<\/td>\n25000960<\/a><\/td>\nTBEV (strain Neudoerfl)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td>\n<\/tr>\n
GSN<\/em><\/td>\ngelsolin<\/td>\n2934<\/a><\/td>\n<\/td>\n[Ku\u0142akowska A et al., 2011]<\/td>\n21389683<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vivo, blood [Ku\u0142akowska A et al., 2011]<\/td>\n<\/tr>\n
GZMB<\/em><\/td>\ngranzyme B<\/td>\n3002<\/a><\/td>\nGzm B<\/td>\n[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vivo, human NK cells in response to\u00a0TBEV\u00a0infection [Blom K et al., 2016]<\/td>\n<\/tr>\n
[Blom K et al., 2015]<\/td>\n25611738<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nIn vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td>\n<\/tr>\n
[Fujii Y et al., 2011]<\/td>\n21830901<\/a><\/td>\nTBEV Oshima 5-10 strain<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
GZMM<\/em><\/td>\ngranzyme M<\/td>\n3004<\/a><\/td>\nGzm A<\/td>\n[Fujii Y et al., 2011]<\/td>\n21830901<\/a><\/td>\nTBEV Oshima 5-10 strain<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
HMOX1<\/em><\/td>\nheme oxygenase 1<\/td>\n3162<\/a><\/td>\n<\/td>\n[Kuzmenko YV et al., 2016a]<\/td>\n27875810<\/a><\/td>\nTBEV<\/td>\nNS1<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, HEK 293T cells (Human Embryonic Kidney 293 transformed with large T antigen), RT-qPCR [Kuzmenko YV et al., 2016a]<\/td>\n<\/tr>\n
HSPA1A<\/em><\/td>\nheat shock protein family A (Hsp70) member 1A<\/td>\n3303<\/a><\/td>\n\u00a0Hsp72<\/td>\n[Yu C. et al., 2013]<\/td>\n24177270<\/a><\/td>\nTBEV (strain K23)<\/td>\nTBEV<\/td>\nAfrican Green\u00a0 Monkey<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vitro,\u00a0 Vero E6 (Monkey African Green kidney A subclone of Vero76) cells,\u00a0 A549 [Yu C. et al., 2013]<\/td>\n<\/tr>\n
ICAM1<\/em><\/td>\nintercellular adhesion molecule 1<\/td>\n3383<\/a><\/td>\nCD54<\/td>\n[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Dal\u2019negorsk strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vitro, monocytes [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Primorye-183 strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vitro, monocytes, granulocytes [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
[Moniuszko A et al., 2012]<\/td>\n22705151<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, cerebrospinal fluid (CSF) [Moniuszko A et al., 2012]<\/td>\n<\/tr>\n
[Pietruczuk M et al., 2006]<\/td>\n16909787<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, cerebrospinal fluid (CSF) and serum [Pietruczuk M et al., 2006]<\/td>\n<\/tr>\n
[Zajkowska JM al.,\u00a0 2005]<\/td>\n16245421<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein in stress granules<\/td>\nExpression was upregulated<\/td>\nin vivo, cerebrospinal fluid (CSF) [Zajkowska JM al.,\u00a0 2005]<\/td>\n<\/tr>\n
ICAM2<\/em><\/td>\nintercellular adhesion molecule 2<\/td>\n3384<\/a><\/td>\n<\/td>\n[Zajkowska JM al.,\u00a0 2005]<\/td>\n16245421<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo,\u00a0 serum [Zajkowska JM al.,\u00a0 2005]<\/td>\n<\/tr>\n
[Pietruczuk M et al., 2006]<\/td>\n16909787<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, cerebrospinal fluid (CSF) [Pietruczuk M et al., 2006]<\/td>\n<\/tr>\n
ICAM3<\/em><\/td>\nintercellular adhesion molecule 3<\/td>\n3385<\/a><\/td>\n<\/td>\n[Zajkowska JM al.,\u00a0 2005]<\/td>\n16245421<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, cerebrospinal fluid (CSF) [Zajkowska JM al.,\u00a0 2005]<\/td>\n<\/tr>\n
[Pietruczuk M et al., 2006]<\/td>\n16909787<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, cerebrospinal fluid (CSF) and serum [Pietruczuk M et al., 2006]<\/td>\n<\/tr>\n
IFIH1<\/em><\/td>\ninterferon induced with helicase C domain 1<\/td>\n64135<\/a><\/td>\nMDA5<\/td>\n[Zhang X et al., 2016]<\/td>\n27576490<\/a><\/td>\nTBEV, Far Eastern strain<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vitro: Human\u00a0 T98G cells [Zhang X et al., 2016]<\/td>\n<\/tr>\n
IFIT1<\/em><\/td>\ninterferon induced protein with tetratricopeptide repeats 1<\/td>\n3434<\/a><\/td>\nIFI-56K<\/td>\n[Gavrilov BG et al., 2003]<\/td>\n12708317<\/a><\/td>\nTBEV (strain 205)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, Human embryonic kidney cell line RH Infected with Tick-borne Encephalitis Virus [Gavrilov BG et al., 2003]<\/td>\n<\/tr>\n
IFIT2<\/em><\/td>\ninterferon induced protein with tetratricopeptide repeats 2<\/td>\n3433<\/a><\/td>\nIFI-54k<\/td>\n[Gavrilov BG et al., 2003]<\/td>\n12708317<\/a><\/td>\nTBEV (strain 205)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, Human embryonic kidney cell line RH Infected with Tick-borne Encephalitis Virus [Gavrilov BG et al., 2003]<\/td>\n<\/tr>\n
IFNA1<\/em><\/td>\ninterferon alpha 1<\/td>\n3439<\/a><\/td>\nIFN-a, interferon alpha<\/td>\n[Palus M et al., 2014a]<\/td>\n25000960<\/a><\/td>\nTBEV (strain Neudoerfl)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td>\n<\/tr>\n
[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td>\n<\/tr>\n
IFNA2<\/em><\/td>\ninterferon alpha 2<\/td>\n3440<\/a><\/td>\n<\/td>\n[Lindqvist R et al., 2016]<\/td>\n27776548<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro,\u00a0 Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]<\/td>\n<\/tr>\n
IFNAR1<\/em><\/td>\ninterferon alpha and beta receptor subunit 1<\/td>\n3454<\/a><\/td>\n<\/td>\n[Lubick KJ et al., 2015]<\/td>\n26159719<\/a><\/td>\nTBEV (Sofjin strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vitro, HEK293 (Human Embryonic Kidney) cells [Lubick KJ et al., 2015]<\/td>\n<\/tr>\n
IFNB1<\/em><\/td>\ninterferon beta 1<\/td>\n3456<\/a><\/td>\n<\/td>\n[Lindqvist R et al., 2016]<\/td>\n27776548<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro,\u00a0 Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]<\/td>\n<\/tr>\n
[Grygorczuk S et al., 2015]<\/td>\n25461390<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, CSF and serum [Grygorczuk S et al., 2015]<\/td>\n<\/tr>\n
IFNG<\/em><\/td>\ninterferon gamma<\/td>\n3458<\/a><\/td>\n\u00a0IFN-\u03b3<\/td>\n[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo,\u00a0 plasma [Blom K et al., 2016]<\/td>\n<\/tr>\n
[Aberle JH et al., 2015]<\/td>\n26465323<\/a><\/td>\nTBEV<\/td>\nTBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, TBEV-specific polyfunctional human CD4+ T cells (L-2+IFN-\u03b3+) [Aberle JH et al., 2015]<\/td>\n<\/tr>\n
[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
[Gomez I et al., 2003]<\/td>\n14583154<\/a><\/td>\nTBEV (vaccine against TBE)<\/td>\nE protein (trancated)<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, CD4+ T lymphocytes\u00a0 specific for E protein\u00a0 from healthy blood donors vaccinated against TBEV with FSME\u00ae-IMMUN Inject (Baxter IMMUNO, Austria) [Gomez I et al., 2003]<\/td>\n<\/tr>\n
IFNL3<\/em><\/td>\ninterferon lambda 3<\/td>\n282617<\/a><\/td>\nIL28B<\/td>\n[Grygorczuk S et al., 2015]<\/td>\n25461391<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, CSF [Grygorczuk S et al., 2015]<\/td>\n<\/tr>\n
IKZF2<\/em><\/td>\nIKAROS family zinc finger 2<\/td>\n22807<\/a><\/td>\nHelios<\/td>\n[Blom K et al., 2015]<\/td>\n25611738<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nIn vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td>\n<\/tr>\n
IL10<\/em><\/td>\ninterleukin 10<\/td>\n3586<\/a><\/td>\n<\/td>\n[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
[Grygorczuk S et al., 2015]<\/td>\n25461389<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, CSF and serum [Grygorczuk S et al., 2015]<\/td>\n<\/tr>\n
IL12A<\/em><\/td>\ninterleukin 12A<\/td>\n3592<\/a><\/td>\n<\/td>\n[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td>\n<\/tr>\n
IL12B<\/em><\/td>\ninterleukin 12B<\/td>\n3593<\/a><\/td>\n<\/td>\n[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td>\n<\/tr>\n
IL15<\/em><\/td>\ninterleukin 15<\/td>\n3600<\/a><\/td>\n<\/td>\n[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td>\n<\/tr>\n
IL18<\/em><\/td>\ninterleukin 18<\/td>\n3606<\/a><\/td>\n<\/td>\n[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td>\n<\/tr>\n
IL1A<\/em><\/td>\ninterleukin 1 alpha<\/td>\n3552<\/a><\/td>\n<\/td>\n[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
IL1B<\/em><\/td>\ninterleukin 1 beta<\/td>\n3553<\/a><\/td>\n<\/td>\n[Palus M et al., 2014a]<\/td>\n25000960<\/a><\/td>\nTBEV (strain Neudoerfl)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td>\n<\/tr>\n
[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
IL2<\/em><\/td>\ninterleukin 2<\/td>\n3558<\/a><\/td>\n<\/td>\n[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td>\n<\/tr>\n
[Aberle JH et al., 2015]<\/td>\n26465323<\/a><\/td>\nTBEV<\/td>\nTBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vivo, TBEV-specific polyfunctional human CD4+ T cells [Aberle JH et al., 2015]<\/td>\n<\/tr>\n
IL2RA<\/em><\/td>\ninterleukin 2 receptor subunit alpha<\/td>\n3559<\/a><\/td>\nCD25<\/td>\n[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Dal\u2019negorsk strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vitro, NK cells [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Primorye-183 strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vitro, CD8 T-lymphocytes [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
[Fujii Y et al., 2011]<\/td>\n21830901<\/a><\/td>\nTBEV Oshima 5-10 strain<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
IL4<\/em><\/td>\ninterleukin 4<\/td>\n3565<\/a><\/td>\n<\/td>\n[Tun MM et al., 2014]<\/td>\n24938868<\/a><\/td>\nTBEV, Oshima strain, Sofjin strain<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was downregulated<\/td>\nIn vivo, spleen [Tun MM et al., 2014]<\/td>\n<\/tr>\n
IL5<\/em><\/td>\ninterleukin 5<\/td>\n3567<\/a><\/td>\n<\/td>\n[Gomez I et al., 2003]<\/td>\n14583154<\/a><\/td>\nTBEV (vaccine against TBE)<\/td>\nE protein (trancated)<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, CD4+ T lymphocytes\u00a0 specific for E protein\u00a0 from healthy blood donors vaccinated against TBEV with FSME\u00ae-IMMUN Inject (Baxter IMMUNO, Austria) [Gomez I et al., 2003]<\/td>\n<\/tr>\n
IL6<\/em><\/td>\ninterleukin 6<\/td>\n3569<\/a><\/td>\n<\/td>\n[Palus M et al., 2014a]<\/td>\n25000960<\/a><\/td>\nTBEV (strain Neudoerfl)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td>\n<\/tr>\n
[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo,\u00a0 plasma [Blom K et al., 2016]<\/td>\n<\/tr>\n
[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
IL7R<\/em><\/td>\ninterleukin 7 receptor<\/td>\n3575<\/a><\/td>\nCD127<\/td>\n[Blom K et al., 2015]<\/td>\n25611738<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td>\n<\/tr>\n
IRF1<\/em><\/td>\ninterferon regulatory factor 1<\/td>\n3659<\/a><\/td>\n<\/td>\n[Robertson SJ et al., 2014]<\/td>\n24532583<\/a><\/td>\nTBEV (Sofjin strain)<\/td>\nTBEV<\/td>\nMouse<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vitro, bone-marrow derived dendritic cells [Robertson SJ et al., 2014]<\/td>\n<\/tr>\n
IRF3<\/em><\/td>\ninterferon regulatory factor 3<\/td>\n3661<\/a><\/td>\n<\/td>\n[Zhang X et al., 2016]<\/td>\n27576490<\/a><\/td>\nTBEV, Far Eastern strain<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein (phosphorylated)<\/td>\nPhosphorilation was upregulated<\/td>\nin vitro: Human\u00a0 T98G cells [Zhang X et al., 2016]<\/td>\n<\/tr>\n
ITGAM<\/em><\/td>\nintegrin subunit alpha M<\/td>\n3684<\/a><\/td>\nCD11b<\/td>\n[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Dal\u2019negorsk strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vitro, monocytes [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
[Krylova NV et al., 2015]<\/td>\n25695407<\/a><\/td>\nTBEV (Primorye-183 strain)<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vitro, monocytes, granulocytes, and NK cells [Krylova NV et al., 2015]<\/td>\n<\/tr>\n
LILRA4<\/em><\/td>\nleukocyte immunoglobulin like receptor A4<\/td>\n23547<\/a><\/td>\nILT7<\/td>\n[Dillmann C et al., 2016]<\/td>\n26783340<\/a><\/td>\nTBEV (FSME-IMMUN -inactivated whole virus vaccine against TBE)<\/td>\nFSME-IMMUN -inactivated whole virus vaccine against TBE<\/td>\nHuman<\/td>\nprotein (cell surface)<\/td>\nExpression was downregulated<\/td>\nin vitro, human plasmacytoid dendritic cells (pDCs) [Dillmann C et al., 2016]<\/td>\n<\/tr>\n
LTF<\/em><\/td>\nlactotransferrin<\/td>\n4057<\/a><\/td>\n<\/td>\n[Merzeniuk ZA et al., 2003]<\/td>\n12774664<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, liquor and blood of patients with\u00a0tick-borne encephalitis [Merzeniuk ZA et al., 2000]<\/td>\n<\/tr>\n
MKI67<\/em><\/td>\nmarker of proliferation Ki-67<\/td>\n4288<\/a><\/td>\nKi67<\/td>\n[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, human NK cells in response to\u00a0TBEV\u00a0infection [Blom K et al., 2016]<\/td>\n<\/tr>\n
MMP9<\/em><\/td>\nmatrix metallopeptidase 9<\/td>\n4318<\/a><\/td>\n<\/td>\n[Palus M et al., 2014a]<\/td>\n25000960<\/a><\/td>\nTBEV (strain Neudoerfl)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td>\n<\/tr>\n
[Palus M et al., 2014b]<\/td>\n25000960<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, serum [Palus M et al., 2014b]<\/td>\n<\/tr>\n
NQO1<\/em><\/td>\nNAD(P)H quinone dehydrogenase 1<\/td>\n1728<\/a><\/td>\n<\/td>\n[Kuzmenko YV et al., 2016a]<\/td>\n27875810<\/a><\/td>\nTBEV<\/td>\nNS1<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, HEK 293T cells (Human Embryonic Kidney 293 transformed with large T antigen), RT-qPCR [Kuzmenko YV et al., 2016a]<\/td>\n<\/tr>\n
OAS1<\/em><\/td>\n2′-5′-oligoadenylate synthetase 1<\/td>\n4938<\/a><\/td>\n<\/td>\n[Yoshii K et al., 2013]<\/td>\n23266832<\/a><\/td>\nTBEV (Sofjin-HO or Oshima 5-10 strain)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Yoshii K et al., 2013]<\/td>\n<\/tr>\n
PDCD1<\/em><\/td>\nprogrammed cell death 1<\/td>\n5133<\/a><\/td>\nPD-1<\/td>\n[Blom K et al., 2015]<\/td>\n25611738<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo,\u00a0 CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]<\/td>\n<\/tr>\n
PRF1<\/em><\/td>\nperforin 1<\/td>\n5551<\/a><\/td>\n<\/td>\n[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was downregulated<\/td>\nin vivo, human NK cells in response to\u00a0TBEV\u00a0infection [Blom K et al., 2016]<\/td>\n<\/tr>\n
[Blom K et al., 2015]<\/td>\n25611738<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo,\u00a0 CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]<\/td>\n<\/tr>\n
PRF1<\/em><\/td>\nperforin 1<\/td>\n5551<\/a><\/td>\n<\/td>\n[Fujii Y et al., 2011]<\/td>\n21830901<\/a><\/td>\nTBEV Oshima 5-10 strain<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
PSMB10<\/em><\/td>\nproteasome subunit beta 10<\/td>\n5699<\/a><\/td>\n<\/td>\n[Kuzmenko YV et al., 2016b]<\/td>\n27239857<\/a><\/td>\nTBEV (Western subtype)<\/td>\nNS1<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, HeLa [Kuzmenko YV et al., 2016b]<\/td>\n<\/tr>\n
PSMB8<\/em><\/td>\nproteasome subunit beta 8<\/td>\n5696<\/a><\/td>\n<\/td>\n[Kuzmenko YV et al., 2016b]<\/td>\n27239857<\/a><\/td>\nTBEV (Western subtype)<\/td>\nNS1<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, HeLa [Kuzmenko YV et al., 2016b]<\/td>\n<\/tr>\n
RSAD2<\/em><\/td>\nradical S-adenosyl methionine domain containing 2<\/td>\n91543<\/a><\/td>\nViperin<\/td>\n[Lindqvist R et al., 2016]<\/td>\n27776548<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro,\u00a0 Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]<\/td>\n<\/tr>\n
SOCS1<\/em><\/td>\nsuppressor of cytokine signaling 1<\/td>\n8651<\/a><\/td>\n<\/td>\n[Mansfield KL et al., 2010]<\/td>\n20854017<\/a><\/td>\nTBEV, strain Neudoerfl<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
SOCS3<\/em><\/td>\nsuppressor of cytokine signaling 3<\/td>\n9021<\/a><\/td>\n<\/td>\n[Mansfield KL et al., 2010]<\/td>\n20854017<\/a><\/td>\nTBEV, strain Neudoerfl<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
TBK1<\/em><\/td>\nTANK binding kinase 1<\/td>\n29110<\/a><\/td>\n<\/td>\n[Zhang X et al., 2016]<\/td>\n27576490<\/a><\/td>\nTBEV, Far Eastern strain<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein (phosphorylated)<\/td>\nPhosphorilation was upregulated<\/td>\nin vitro: Human\u00a0 T98G cells [Zhang X et al., 2016]<\/td>\n<\/tr>\n
TBX21<\/em><\/td>\nT-box 21<\/td>\n30009<\/a><\/td>\nTbet, T-bet<\/td>\n[Aberle JH et al., 2015]<\/td>\n26465323<\/a><\/td>\nTBEV<\/td>\nTBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo, TBEV-specific polyfunctional human CD4+ T cells (L-2+IFN-\u03b3+) [Aberle JH et al., 2015]<\/td>\n<\/tr>\n
[Blom K et al., 2015]<\/td>\n25611738<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td>\n<\/tr>\n
TNF<\/em><\/td>\ntumor necrosis factor<\/td>\n7124<\/a><\/td>\ntumour necrosis factor \u03b1<\/td>\n[Palus M et al., 2014a]<\/td>\n25000960<\/a><\/td>\nTBEV (strain Neudoerfl)<\/td>\nTBEV<\/td>\nHuman<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td>\n<\/tr>\n
[Palus M et al., 2013]<\/td>\n23805778<\/a><\/td>\nTBEV ( strain Neudoerfl)<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td>\n<\/tr>\n
[Blom K et al., 2016]<\/td>\n27543616<\/a><\/td>\nTBEV<\/td>\nTBEV<\/td>\nHuman<\/td>\nprotein<\/td>\nExpression was upregulated<\/td>\nin vivo,\u00a0 plasma [Blom K et al., 2016]<\/td>\n<\/tr>\n
TNF<\/em><\/td>\ntumor necrosis factor<\/td>\n7124<\/a><\/td>\nTNFa<\/td>\n[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nTBEV<\/td>\nMouse<\/td>\nmRNA<\/td>\nExpression was upregulated<\/td>\nin vivo, brain [Fujii Y et al., 2011]<\/td>\n<\/tr>\n
XBP1<\/em><\/td>\nX-box binding protein 1<\/td>\n7494<\/a><\/td>\nsXBP1<\/td>\n[Yu C. et al., 2013]<\/td>\n24177270<\/a><\/td>\nTBEV (strain K23)<\/td>\nTBEV<\/td>\nAfrican Green\u00a0 Monkey<\/td>\nmRNA, protein<\/td>\nExpression was upregulated<\/td>\nin vitro,\u00a0 Vero E6 (Monkey African Green kidney A subclone of Vero76) cells,\u00a0 A550 [Yu C. et al., 2013]<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

All genes were collected from the research papers. If the publication described a non-human mammalian gene\/protein, the homologous human gene was found and included into the catalog. EntrezGene Official Symbol Official Full Name EntrezGene Gene ID Also known as References PMID Virus, strain Inductor (TBEV or protein) Host organism mRNA expression level or protein expression…<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/25"}],"collection":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/comments?post=25"}],"version-history":[{"count":0,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/25\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/media?parent=25"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}