{"id":29,"date":"2017-08-31T10:02:57","date_gmt":"2017-08-31T07:02:57","guid":{"rendered":"http:\/\/icg.nsc.ru\/encephalitis\/?page_id=29"},"modified":"2017-08-31T10:02:57","modified_gmt":"2017-08-31T07:02:57","slug":"required-for-inhibitory-effect","status":"publish","type":"page","link":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/required-for-inhibitory-effect\/","title":{"rendered":"Genes encoding proteins that were required for inhibitory effect of other proteins against TBEV or attenuated its antiviral activity"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n
EntrezGene
Official
Symbol<\/th>\n		Official Full Name<\/th>\nEntrezGene
Gene ID<\/th>\n		Also
known as<\/th>\n		Other
essential
protein<\/th>\n		References<\/th>\nPMID<\/th>\nType of
interaction<\/th>\n		Virus, strain<\/th>\nHost organism<\/th>\nIn vivo\/in vitro                                        <\/th>\n<\/tr>\n
ARHGEF7<\/em><\/td>\nRho guanine nucleotide exchange factor 7<\/td>\n8874<\/a><\/td>\n\u03b2PIX, BETA-PIX<\/td>\nSCRIB<\/td>\n[Wigerius M et al., 2010]<\/td>\n20363326<\/a><\/td>\nPhysical\u00a0 interactions with important protein<\/td>\nTBEV<\/td>\nHuman<\/td>\nin vitro, PC12 cells derived from a rat pheochromocytoma,\u00a0 COS-7 (fibroblast-like cell lines derived from monkey kidney tissue)\u00a0\u00a0 [Wigerius M et al., 2010].<\/td>\n<\/tr>\n
CIAO1<\/em><\/td>\ncytosolic iron-sulfur assembly component 1<\/td>\n9391<\/a><\/td>\n<\/td>\nRSAD2 \/ Viperin<\/td>\n[Upadhyay AS et al., 2014]<\/td>\n24245804<\/a><\/td>\nPhysical\u00a0 interactions with important protein<\/td>\nTBEV<\/td>\nHuman<\/td>\nin vitro, human HEK293 cells [Upadhyay AS et al., 2014]<\/td>\n<\/tr>\n
ERN1<\/em><\/td>\nendoplasmic reticulum to nucleus signaling 1<\/td>\n2081<\/a><\/td>\nIRE1a<\/td>\nXBP1<\/td>\n[Yu C. et al., 2013]\u00a0 [Yoshida H et al., 2001]<\/td>\n24177270<\/a>, 11779464<\/a><\/td>\nPhysical\u00a0 interactions with important protein<\/td>\nTBEV<\/td>\nHuman, Monkey<\/td>\nin vitro, Hela cells [Yoshida H et al., 2001] Monkey Vero E6 cells [Yu C. et al., 2013] .<\/td>\n<\/tr>\n
PEPD<\/em><\/td>\npeptidase D<\/td>\n5184<\/a><\/td>\n<\/td>\nIFNAR1<\/td>\n[Lubick KJ et al., 2015]<\/td>\n26159719<\/a><\/td>\nInteraction within pathway<\/td>\nTBEV (strain Sofjin)<\/td>\nHuman<\/td>\nin vitro, HEK293 (Human Embryonic Kidney). In vivo, human fibroblasts<\/td>\n<\/tr>\n
RAC1<\/em><\/td>\nras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)<\/td>\n5879<\/a><\/td>\n<\/td>\nSCRIB<\/td>\n[Wigerius M et al., 2010]<\/td>\n20363326<\/a><\/td>\nPhysical\u00a0 interactions with important protein<\/td>\nTBEV<\/td>\nHuman<\/td>\nin vitro, PC12 cells derived from a rat pheochromocytoma,\u00a0 COS-7 (fibroblast-like cell lines derived from monkey kidney tissue)\u00a0\u00a0 [Wigerius M et al., 2010].<\/td>\n<\/tr>\n
S1PR4<\/em><\/td>\nsphingosine-1-phosphate receptor 4<\/td>\n8698<\/a><\/td>\n<\/td>\nLILRA4<\/td>\n[Dillmann C et al., 2016]<\/td>\n26783340<\/a><\/td>\nInteraction within pathway<\/td>\nTBEV (FSME-IMMUN -inactivated whole virus vaccine against TBE)<\/td>\nHuman<\/td>\nin vitro, human plasmacytoid dendritic cells (pDCs)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

EntrezGeneOfficialSymbol Official Full Name EntrezGeneGene ID Alsoknown as Otheressentialprotein References PMID Type ofinteraction Virus, strain Host organism In vivo\/in vitro                                         ARHGEF7 Rho guanine nucleotide exchange factor 7 8874 \u03b2PIX, BETA-PIX SCRIB [Wigerius M et al., 2010] 20363326 Physical\u00a0 interactions with important protein TBEV Human in vitro, PC12 cells derived from a rat pheochromocytoma,\u00a0 COS-7 (fibroblast-like…<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/29"}],"collection":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/comments?post=29"}],"version-history":[{"count":0,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/29\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/media?parent=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}