{"id":31,"date":"2017-08-31T10:03:24","date_gmt":"2017-08-31T07:03:24","guid":{"rendered":"http:\/\/icg.nsc.ru\/encephalitis\/?page_id=31"},"modified":"2017-08-31T10:03:24","modified_gmt":"2017-08-31T07:03:24","slug":"knockout","status":"publish","type":"page","link":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/knockout\/","title":{"rendered":"Knockout of these genes in mice increased mortality rates or affected the other clinical manifestations of the disease"},"content":{"rendered":"

All genes were collected from the research papers.
\nIf the publication described a non-human mammalian gene\/protein, the homologous human gene was found and included into the catalog.<\/p>\n\n\n\n\n\n\n\n\n\n
EntrezGene
Official
Symbol<\/th>\n		Official Full Name<\/th>\nEntrezGene
Gene ID<\/th>\n		Also
known as<\/th>\n		References<\/th>\nPMID<\/th>\nVirus,
strain<\/th>\n		In vivo\/
in vitro<\/th>\n		Host
organism<\/th>\n		Effect<\/th>\nExperiment                                                            <\/th>\n<\/tr>\n
MAVS<\/em><\/td>\nmitochondrial antiviral signaling protein<\/td>\n57506<\/a><\/td>\nIPS-1<\/td>\n[Kurhade C et al., 2016]<\/td>\n26819220<\/a><\/td>\nTBEV strain Hypr<\/td>\nin vivo<\/td>\nmouse<\/td>\nDecreased median survival time [Kurhade C et al., 2016]<\/td>\nSix- to ten-weekold mice were intraperitoneally infected with\u00a0 TBEV\u00a0 [Kurhade C et al., 2016]<\/td>\n<\/tr>\n
CD8A<\/em><\/td>\nCD8a molecule<\/td>\n925<\/a><\/td>\nCD8a<\/td>\n[R\u016f\u017eek D et al., 2011]<\/td>\n21629771<\/a><\/td>\nTBEV, strain Neudoerfl\/IRE<\/td>\nin vivo<\/td>\nmouse<\/td>\nSlower development of the disease [R\u016f\u017eek D et al., 2011]<\/td>\nCD8a-\/- mice were inoculated subcutaneously with TBEV (100 pfu) Sodium fluorescein (Sigma-Aldrich), was used to detect fluid shifts between the circulation and CNS, which occur when BBB permeability becomes enhanced [R\u016f\u017eek D et al., 2011]<\/td>\n<\/tr>\n
TNF<\/em><\/td>\ntumor necrosis factor<\/td>\n7124<\/a><\/td>\nTNF-a<\/td>\n[Tun MM et al., 2014]<\/td>\n24938868<\/a><\/td>\nTBEV, Oshima strain<\/td>\nin vivo<\/td>\nmouse<\/td>\nIncreased mortality rates [Tun MM et al., 2014]<\/td>\nMice were infected subcutaneously with 104 pfu of Oshima strains and were monitored daily\u00a0\u00a0 [Tun MM et al., 2014]<\/td>\n<\/tr>\n
IL10<\/em><\/td>\ninterleukin 10<\/td>\n3586<\/a><\/td>\nIL-10<\/td>\n[Tun MM et al., 2014]<\/td>\n24938868<\/a><\/td>\nTBEV, Oshima strain<\/td>\nin vivo<\/td>\nmouse<\/td>\nIncreased mortality rates [Tun MM et al., 2014]<\/td>\nMice were infected subcutaneously with 104 pfu of Oshima strains and were monitored daily\u00a0\u00a0 [Tun MM et al., 2014]<\/td>\n<\/tr>\n
TIA1<\/em><\/td>\nTIA1 cytotoxic granule associated RNA binding protein<\/td>\n7072<\/a><\/td>\nTIA-1<\/td>\n[Albornoz A et al., 2014]<\/td>\n24696465<\/a><\/td>\nTBEV, strain Neudoerfl<\/td>\nin vitro, mouse embryonic fibroblast (MEF)<\/td>\nmouse<\/td>\nIncrease in TBEV extracellular infectivity [Albornoz A et al., 2014]<\/td>\nMEF TIA-1\u2212\/\u2212 or their control (MEF WT) were infected with TBEV at an MOI of 2. Cell supernatant collected 24 and 48 h p.i. was used to infect Vero cells to measure virus yields (PFU\/ml) from infected MEF TIA-1\u2212\/\u2212 or infected MEF WT samples<\/td>\n<\/tr>\n
TIAL1<\/em><\/td>\nTIA1 cytotoxic granule associated RNA binding protein like 1<\/td>\n7073<\/a><\/td>\nTIAR<\/td>\n[Albornoz A et al., 2014]<\/td>\n24696465<\/a><\/td>\nTBEV, strain Neudoerfl<\/td>\nin vitro, mouse embryonic fibroblast (MEF)<\/td>\nmouse<\/td>\nDecrease in TBEV extracellular infectivity [Albornoz A et al., 2014]<\/td>\nMEF TIAR\u2212\/\u2212 or their control (MEF WT) were infected with TBEV at an MOI of 2. Cell supernatant collected 24 and 48 h p.i. was used to infect Vero cells to measure virus yields (PFU\/ml) from infected MEF TIAR\u2212\/\u2212 or infected MEF WT samples<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

All genes were collected from the research papers. If the publication described a non-human mammalian gene\/protein, the homologous human gene was found and included into the catalog. EntrezGeneOfficialSymbol Official Full Name EntrezGeneGene ID Alsoknown as References PMID Virus,strain In vivo\/in vitro Hostorganism Effect Experiment                                                             MAVS mitochondrial antiviral signaling protein 57506 IPS-1 [Kurhade C et al.,…<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/31"}],"collection":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/comments?post=31"}],"version-history":[{"count":0,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/31\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/media?parent=31"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}