{"id":33,"date":"2017-08-31T10:04:57","date_gmt":"2017-08-31T07:04:57","guid":{"rendered":"http:\/\/icg.nsc.ru\/encephalitis\/?page_id=33"},"modified":"2019-08-29T11:43:04","modified_gmt":"2019-08-29T08:43:04","slug":"the-catalog-of-human-genes","status":"publish","type":"page","link":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/the-catalog-of-human-genes\/","title":{"rendered":"All genes from the catalog (140 genes)"},"content":{"rendered":"\n\n\n\n\t\n\n\t
EntrezGene
\nOfficial
\nSymbol
\n<\/th>		Official Full Name<\/th>EntrezGene
\nGene ID<\/th>		Physical
\ninteraction<\/a><\/th>		Up or
\ndown
\nregulated<\/a><\/th>		Allelic
\nvariant<\/a><\/th>		Increased\/
\nattenuated
\nantiviral
\nactivity<\/a><\/th>		Knockout<\/a><\/th>\n<\/tr>\n<\/thead>\n
A2M<\/td>alpha-2-macroglobulin\u00a0<\/td>2<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
A2M<\/a><\/em><\/td> alpha-2-macroglobulin<\/td> 2<\/a><\/td> <\/td> [Merzeniuk ZA et al., 2000]<\/td> 10925884<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, liquor from patients with the meningeal and focal forms of tick-borne encephalitis [Merzeniuk ZA et al., 2000]<\/td> <\/tr><\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ARHGAP25<\/td>Rho GTPase activating protein 25<\/td>9938<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also known as<\/th> References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV virion
or viral proten
or viral RNA<\/th>		Method<\/th> <\/tr>
ARHGAP25<\/em><\/td> Rho GTPase activating protein 25<\/td> 9938<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td> <\/tr> <\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ARHGEF7<\/td>Rho guanine nucleotide exchange factor 7<\/td>8874<\/a><\/td>0<\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		Other
essential
protein<\/th> 		References<\/th> PMID<\/th> Type of
interaction<\/th> 		Virus, strain<\/th> Host organism<\/th> In vivo\/in vitro<\/th> <\/tr>
ARHGEF7<\/em><\/td> Rho guanine nucleotide exchange factor 7<\/td> 8874<\/a><\/td> \u03b2PIX, BETA-PIX<\/td> SCRIB<\/td> [Wigerius M et al., 2010]<\/td> 20363326<\/a><\/td> Physical\u00a0 interactions with important protein<\/td> TBEV<\/td> Human<\/td> in vitro, PC12 cells derived from a rat pheochromocytoma,\u00a0 COS-7 (fibroblast-like cell lines derived from monkey kidney tissue)\u00a0\u00a0 [Wigerius M et al., 2010].<\/td><\/tr><\/table><\/div> Close<\/a><\/td>0<\/td>\n<\/tr>\n
ARID1B<\/td>AT-rich interaction domain 1B <\/td>57492<\/a><\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		SNP ID<\/th> Reference<\/th> PMID<\/th> SNP location<\/th> Population<\/th> Phenotypic trait caused
by allelic variants<\/th> <\/tr>
ARID1B<\/em><\/td> AT-rich interaction domain 1B<\/td> 57492<\/a><\/td> <\/td> rs287886<\/a><\/td> [Grygorczuk S et al., 2015]<\/td> 25461389<\/a><\/td> ARID1B,\u00a0 first intron<\/td> Polish population<\/td> IL-10 concentration in CSF in TBE patients [Grygorczuk S et al., 2015]<\/td> <\/tr><\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>0<\/td>\n<\/tr>\n
ARID2<\/td>AT-rich interaction domain 2<\/td>196528<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
ARID2<\/em><\/td> AT-rich interaction domain 2<\/td> 196528<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td> <\/tr><\/table> <\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ARNTL<\/td>aryl hydrocarbon receptor nuclear translocator like<\/td>406<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
ARNTL<\/em><\/td> aryl hydrocarbon receptor nuclear translocator like<\/td> 406<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ATF6<\/td>activating transcription factor 6<\/td>22926<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
ATF6<\/em><\/td> activating transcription factor 6<\/td> 22926<\/a><\/td> <\/td> [Yu C. et al., 2013]<\/td> 24177270<\/a><\/td> TBEV (strain K23)<\/td> TBEV<\/td> African Green\u00a0 Monkey<\/td> protein (cleaved form)<\/td> Expression was upregulated<\/td> in vitro,\u00a0 Vero E6 (Monkey African Green kidney A subclone of Vero76) cells,\u00a0 A552 [Yu C. et al., 2013]<\/td><\/tr><\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
BCL2<\/td>BCL2, apoptosis regulator<\/td>596<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
BCL2<\/em><\/td> BCL2, apoptosis regulator<\/td> 596<\/a><\/td> <\/td> [Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vivo, human NK cells in response to\u00a0TBEV\u00a0infection [Blom K et al., 2016]<\/td> <\/tr>
[Blom K et al., 2015]<\/td> 25611738<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vivo,\u00a0 CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
BICD1<\/td>BICD cargo adaptor 1<\/td>636<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
BICD1<\/em><\/td> BICD cargo adaptor 1<\/td> 636<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CASK<\/td>calcium\/calmodulin dependent serine protein kinase<\/td>8573<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
CASK<\/em><\/td> calcium\/calmodulin dependent serine protein kinase<\/td> 8573<\/a><\/td> <\/td> [Melik W et al., 2012]<\/td> 22796133<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Melik W et al., 2012]<\/td> in vitro, in vitro, PDZ array membranes [Melik W et al., 2012]<\/td><\/tr> <\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CCDC14<\/td>coiled-coil domain containing 14<\/td>64770<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
CCDC14<\/em><\/td> coiled-coil domain containing 14<\/td> 64770<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CCL2<\/td>C-C motif chemokine ligand 2<\/td>6347<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CCL2<\/em><\/td> C-C motif chemokine ligand 2<\/td> 6347<\/a><\/td> MCP-1\/CCL2, monocyte chemoattractant protein<\/td> [Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td> <\/tr>
[R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CCL3<\/td>C-C motif chemokine ligand 3<\/td>6348<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CCL3<\/em><\/td> C-C motif chemokine ligand 3<\/td> 6348<\/a><\/td> MIP-1\u03b1, MIP-1a, macrophage inflammatory protein 1\u03b1<\/td> [Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td> <\/tr>
[R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CCL4<\/td>C-C motif chemokine ligand 4<\/td>6351<\/a><\/td>0<\/td>1<\/a>
<\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CCL4<\/em><\/td> C-C motif chemokine ligand 4<\/td> 6351<\/a><\/td> MIP-1b\/CCL-4, MIP-1beta, MIP-1b<\/td> [Palus M et al., 2014a]<\/td> 25000960<\/a><\/td> TBEV (strain Neudoerfl)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td> <\/tr>
[Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td> <\/tr>
[R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CCL5<\/td>C-C motif chemokine ligand 5\u00a0<\/td>6352<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CCL5<\/em><\/td> C-C motif chemokine ligand 5<\/td> 6352<\/a><\/td> RANTES<\/td> [Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td> <\/tr>
[Zhang X et al., 2016]<\/td> 27576490<\/a><\/td> TBEV, Far Eastern strain<\/td> TBEV<\/td> Mouse, Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo: mouse, in vitro: human brain-derived cell lines and primary progenitor-derived astrocytes [Zhang X et al., 2016]<\/td> <\/tr>
[R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CCR5<\/td>C-C motif chemokine receptor 5 (gene\/pseudogene) <\/td>1234<\/a><\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		SNP ID<\/th> Reference<\/th> PMID<\/th> SNP location<\/th> Population<\/th> Phenotypic trait caused
by allelic variants<\/th> <\/tr>
CCR5<\/em><\/td> C-C motif chemokine receptor 5 (gene\/pseudogene)<\/td> 1234<\/a><\/td> <\/td> rs333 (CCR5D32)<\/a><\/td> [Mickien\u0117 A\u00a0 et al., 2014] [Kindberg E et al., 2008]<\/td> 25226020<\/a>, 18179389<\/a><\/td> CCR5, exon 1 or 2<\/td> Lithuanian Population<\/td> The prevalence of CCR5D32 homozygotes was higher in TBE patients than in controls (p,0.05) [Mickien\u0117 A et al., 2014]. CCR5 32 allele prevalence increased with the clinical severity of disease\u00a0 [Kindberg E et al., 2008]<\/td><\/tr> <\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>0<\/td>\n<\/tr>\n
CD209<\/td>CD209 molecule <\/td>30835<\/a><\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		SNP ID<\/th> Reference<\/th> PMID<\/th> SNP location<\/th> Population<\/th> Phenotypic trait caused
by allelic variants<\/th> <\/tr>
CD209<\/em><\/td> CD209 molecule<\/td> 30835<\/a><\/td> <\/td> rs2287886<\/a><\/td> [Barkhash AV et al., 2012]<\/td> 22061615<\/a><\/td> CD209, promoter region<\/td> Russian population<\/td> Predisposition to severe forms of TBE in the Russian population [Barkhash AV et al., 2012]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div> <\/div> <\/td>0<\/td>0<\/td>\n<\/tr>\n
CD27<\/td>CD27\u00a0molecule\u00a0<\/td>939<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CD27<\/em><\/td> CD27\u00a0molecule<\/td> 939<\/a><\/td> <\/td> [Blom K et al., 2015]<\/td> 25611738<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CD3E<\/td>CD3e molecule<\/td>916<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CD3E<\/em><\/td> CD3e molecule<\/td> 916<\/a><\/td> CD3<\/td> [Fujii Y et al., 2011]<\/td> 21830901<\/a><\/td> TBEV Oshima 5-10 strain<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CD4<\/td>CD4 molecule<\/td>920<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CD4<\/em><\/td> CD4 molecule<\/td> 920<\/a><\/td> <\/td> [Fujii Y et al., 2011]<\/td> 21830901<\/a><\/td> TBEV Oshima 5-10 strain<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td> <\/tr>
[R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CD40<\/td>CD40 molecule<\/td>958<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CD40<\/em><\/td> CD40 molecule<\/td> 958<\/a><\/td> <\/td> [Zajkowska JM al.,\u00a0 2006]<\/td> 16463218<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, CSF [Zajkowska JM al.,\u00a0 2006]<\/td> <\/tr> <\/table> <\/div> Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CD40LG<\/td>CD40 ligand<\/td>959<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CD40LG<\/em><\/td> CD40 ligand<\/td> 959<\/a><\/td> CD40L<\/td> [Zajkowska JM al.,\u00a0 2006]<\/td> 16463218<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo,\u00a0 serum [Zajkowska JM al.,\u00a0 2005]<\/td> <\/tr>
[Zajkowska JM al.,\u00a0 2006]<\/td> 16463218<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, CSF [Zajkowska JM al.,\u00a0 2006]<\/td><\/tr> <\/table> <\/div> Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CD69<\/td>CD69 molecule<\/td>969<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CD69<\/em><\/td> CD69 molecule<\/td> 969<\/a><\/td> <\/td> [Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Dal\u2019negorsk strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vitro, monocytes, NK cells [Krylova NV et al., 2015]<\/td> <\/tr>
[Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Dal\u2019negorsk strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vitro, CD8 T-lymphocytes [Krylova NV et al., 2015]<\/td> <\/tr>
[Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Primorye-183 strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vitro, monocytes, granulocytes [Krylova NV et al., 2015]<\/td> <\/tr>
[Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Primorye-183 strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vitro, NK cells, CD8 + Tlymphocytes, and CD4 + T-lymphocytes [Krylova NV et al., 2015]<\/td> <\/tr>
[Fujii Y et al., 2011]<\/td> 21830901<\/a><\/td> TBEV Oshima 5-10 strain<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CD8A<\/td>CD8a molecule<\/td>925<\/a><\/td>0<\/td>1<\/a>
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CD8A<\/em><\/td> CD8a molecule<\/td> 925<\/a><\/td> CD8<\/td> [Fujii Y et al., 2011]<\/td> 21830901<\/a><\/td> TBEV Oshima 5-10 strain<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td> <\/tr>
[R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		In vivo\/
in vitro<\/th> 		Host
organism<\/th> 		Effect<\/th> Experiment<\/th> <\/tr>
CD8A<\/em><\/td> CD8a molecule<\/td> 925<\/a><\/td> CD8a<\/td> [R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> in vivo<\/td> mouse<\/td> Slower development of the disease [R\u016f\u017eek D et al., 2011]<\/td> CD8a-\/- mice were inoculated subcutaneously with TBEV (100 pfu) Sodium fluorescein (Sigma-Aldrich), was used to detect fluid shifts between the circulation and CNS, which occur when BBB permeability becomes enhanced [R\u016f\u017eek D et al., 2011]<\/td><\/tr><\/table><\/div> Close<\/a> <\/div> <\/div><\/td>\n<\/tr>\n
CIAO1<\/td>cytosolic iron-sulfur assembly component 1<\/td>9391<\/a><\/td>0<\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		Other
essential
protein<\/th> 		References<\/th> PMID<\/th> Type of
interaction<\/th> 		Virus, strain<\/th> Host organism<\/th> In vivo\/in vitro<\/th> <\/tr>
CIAO1<\/em><\/td> cytosolic iron-sulfur assembly component 1<\/td> 9391<\/a><\/td> <\/td> RSAD2 \/ Viperin<\/td> [Upadhyay AS et al., 2014]<\/td> 24245804<\/a><\/td> Physical\u00a0 interactions with important protein<\/td> TBEV<\/td> Human<\/td> in vitro, human HEK293 cells [Upadhyay AS et al., 2014]<\/td><\/tr><\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>\n<\/tr>\n
CXCL10<\/td>C-X-C motif chemokine ligand 10<\/td>3627<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CXCL10<\/em><\/td> C-X-C motif chemokine ligand 10<\/td> 3627<\/a><\/td> IP-10\/CXCL10, IP-10, interferon \u03b3-induced protein 10,\u00a0 IFN-\u03b3-induced protein 10<\/td> [Palus M et al., 2014a]<\/td> 25000960<\/a><\/td> TBEV (strain Neudoerfl)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td> <\/tr>
[Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td> <\/tr>
[Zajkowska J et al., 2011]<\/td> 22008312<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, serum, CSF [Zajkowska J et al., 2011]<\/td> <\/tr>
[R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CXCL11<\/td>C-X-C motif chemokine ligand 11<\/td>6373<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CXCL11<\/em><\/td> C-X-C motif chemokine ligand 11<\/td> 6373<\/a><\/td> I-TAC<\/td> [Zajkowska J et al., 2011]<\/td> 22008312<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, CSF [Zajkowska J et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CXCL12<\/td>C-X-C motif chemokine ligand 12<\/td>6387<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CXCL12<\/em><\/td> C-X-C motif chemokine ligand 12<\/td> 6387<\/a><\/td> SDF-1\u03b1<\/td> [Zajkowska J et al., 2011]<\/td> 22008312<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, CSF [Zajkowska J et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CXCL13<\/td>C-X-C motif chemokine ligand 13 <\/td>10563<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CXCL13<\/em><\/td> C-X-C motif chemokine ligand 13<\/td> 10563<\/a><\/td> BLC\/BCA-1<\/td> [Zajkowska J et al., 2011]<\/td> 22008312<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, serum, CSF [Zajkowska J et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
CXCL8<\/td>C-X-C motif chemokine ligand 8<\/td>3576<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
CXCL8<\/em><\/td> C-X-C motif chemokine ligand 8<\/td> 3576<\/a><\/td> IL-8<\/td> [Palus M et al., 2014a]<\/td> 25000960<\/a><\/td> TBEV (strain Neudoerfl)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td> <\/tr>
[Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo,\u00a0 plasma [Blom K et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
DDX58<\/td>DExD\/H-box helicase 58<\/td>23586<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
DDX58<\/em><\/td> DExD\/H-box helicase 58<\/td> 23586<\/a><\/td> RIG-I<\/td> [Zhang X et al., 2016]<\/td> 27576490<\/a><\/td> TBEV, Far Eastern strain<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vitro: Human\u00a0 T98G cells [Zhang X et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
DNTTIP2<\/td>deoxynucleotidyltransferase terminal interacting protein 2<\/td>30836<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
DNTTIP2<\/em><\/td> deoxynucleotidyltransferase terminal interacting protein 2<\/td> 30836<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div> Close<\/a> <\/div> <\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
EMILIN1<\/td>elastin microfibril interfacer 1<\/td>11117<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
EMILIN1<\/em><\/td> elastin microfibril interfacer 1<\/td> 11117<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div> Close<\/a> <\/div> <\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ENO1<\/td>enolase 1<\/td>2023<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
ENO1<\/em><\/td> enolase 1<\/td> 2023<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div> Close<\/a> <\/div> <\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
EOMES<\/td>eomesodermin <\/td>8320<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
EOMES<\/em><\/td> eomesodermin<\/td> 8320<\/a><\/td> <\/td> [Blom K et al., 2015]<\/td> 25611738<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ERN1<\/td>endoplasmic reticulum to nucleus signaling 1<\/td>2081<\/a><\/td>0<\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		Other
essential
protein<\/th> 		References<\/th> PMID<\/th> Type of
interaction<\/th> 		Virus, strain<\/th> Host organism<\/th> In vivo\/in vitro<\/th> <\/tr>
ERN1<\/em><\/td> endoplasmic reticulum to nucleus signaling 1<\/td> 2081<\/a><\/td> IRE1a<\/td> XBP1<\/td> [Yu C. et al., 2013]\u00a0 [Yoshida H et al., 2001]<\/td> 24177270<\/a>, 11779464<\/a><\/td> Physical\u00a0 interactions with important protein<\/td> TBEV<\/td> Human, Monkey<\/td> in vitro, Hela cells [Yoshida H et al., 2001] Monkey Vero E6 cells [Yu C. et al., 2013] .<\/td><\/tr><\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>\n<\/tr>\n
FAM184A<\/td>family with sequence similarity 184 member A<\/td>79632<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
FAM184A<\/em><\/td> family with sequence similarity 184 member A<\/td> 79632<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div> Close<\/a> <\/div> <\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
FAS<\/td>Fas cell surface death receptor<\/td>355<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
FAS<\/em><\/td> Fas cell surface death receptor<\/td> 355<\/a><\/td> CD95<\/td> [Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Dal\u2019negorsk strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vitro, NK cells [Krylova NV et al., 2015]<\/td> <\/tr>
[Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Primorye-183 strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vitro, NK cells [Krylova NV et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
FASLG<\/td>Fas ligand<\/td>356<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
FASLG<\/em><\/td> Fas ligand<\/td> 356<\/a><\/td> FasL<\/td> [Fujii Y et al., 2011]<\/td> 21830901<\/a><\/td> TBEV Oshima 5-10 strain<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
FURIN<\/td>furin, paired basic amino acid cleaving enzyme<\/td>5045<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
FURIN<\/em><\/td> furin, paired basic amino acid cleaving enzyme<\/td> 5045<\/a><\/td> <\/td> [Stadler K et al., 1997]<\/td> 9343204<\/a><\/td> TBEV<\/td> Bovine<\/td> prM [Stadler K et al., 1997]<\/td> in vitro,\u00a0 BHK-21 (Baby hamster kidney) cells [Stadler K et al., 1997]<\/td><\/tr> <\/table><\/div> Close<\/a> <\/div> <\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
G3BP1<\/td>G3BP stress granule assembly factor 1<\/td>10146<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
G3BP1<\/em><\/td> G3BP stress granule assembly factor 1<\/td> 10146<\/a><\/td> <\/td> [Albornoz A et al., 2014]<\/td> 24696465<\/a><\/td> TBEV strain Neudoerfl<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vitro, human U2OS cells [Albornoz A et al., 2014]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
GFAP<\/td>glial fibrillary acidic protein<\/td>2670<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
GFAP<\/em><\/td> glial fibrillary acidic protein<\/td> 2670<\/a><\/td> <\/td> [Palus M et al., 2014a]<\/td> 25000960<\/a><\/td> TBEV (strain Neudoerfl)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
GIPC1<\/td>GIPC PDZ domain containing family member 1<\/td>10755<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
GIPC1<\/em><\/td> GIPC PDZ domain containing family member 1<\/td> 10755<\/a><\/td> <\/td> [Melik W et al., 2012]<\/td> 22796133<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Melik W et al., 2012]<\/td> in vitro, in vitro, PDZ array membranes [Melik W et al., 2012]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
GOPC<\/td>golgi associated PDZ and coiled-coil motif containing<\/td>57120<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
GOPC<\/em><\/td> golgi associated PDZ and coiled-coil motif containing<\/td> 57120<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
GRIP2<\/td>glutamate receptor interacting protein 2<\/td>80852<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
GRIP2<\/em><\/td> glutamate receptor interacting protein 2<\/td> 80852<\/a><\/td> <\/td> [Melik W et al., 2012]<\/td> 22796133<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Melik W et al., 2012]<\/td> in vitro, in vitro, PDZ array membranes [Melik W et al., 2012]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
GRN<\/td>granulin precursor<\/td>2896<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
GRN<\/em><\/td> granulin precursor<\/td> 2896<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
GSN<\/td>gelsolin<\/td>2934<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
GSN<\/em><\/td> gelsolin<\/td> 2934<\/a><\/td> <\/td> [Ku\u0142akowska A et al., 2011]<\/td> 21389683<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vivo, blood [Ku\u0142akowska A et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
GZMB<\/td>granzyme B<\/td>3002<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
GZMB<\/em><\/td> granzyme B<\/td> 3002<\/a><\/td> Gzm B<\/td> [Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vivo, human NK cells in response to\u00a0TBEV\u00a0infection [Blom K et al., 2016]<\/td> <\/tr>
[Blom K et al., 2015]<\/td> 25611738<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> In vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td> <\/tr>
[Fujii Y et al., 2011]<\/td> 21830901<\/a><\/td> TBEV Oshima 5-10 strain<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
GZMM<\/td>granzyme M<\/td>3004<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
GZMM<\/em><\/td> granzyme M<\/td> 3004<\/a><\/td> Gzm A<\/td> [Fujii Y et al., 2011]<\/td> 21830901<\/a><\/td> TBEV Oshima 5-10 strain<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
HMOX1<\/td>heme oxygenase 1<\/td>3162<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
HMOX1<\/em><\/td> heme oxygenase 1<\/td> 3162<\/a><\/td> <\/td> [Kuzmenko YV et al., 2016a]<\/td> 27875810<\/a><\/td> TBEV<\/td> NS1<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, HEK 293T cells (Human Embryonic Kidney 293 transformed with large T antigen), RT-qPCR [Kuzmenko YV et al., 2016a]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
HNRNPF<\/td>heterogeneous nuclear ribonucleoprotein F<\/td>3185<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
HNRNPF<\/em><\/td> heterogeneous nuclear ribonucleoprotein F<\/td> 3185<\/a><\/td> HNRPF<\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
HSPA1A<\/td>heat shock protein family A (Hsp70) member 1A<\/td>3303<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
HSPA1A<\/em><\/td> heat shock protein family A (Hsp70) member 1A<\/td> 3303<\/a><\/td> \u00a0Hsp72<\/td> [Yu C. et al., 2013]<\/td> 24177270<\/a><\/td> TBEV (strain K23)<\/td> TBEV<\/td> African Green\u00a0 Monkey<\/td> protein<\/td> Expression was upregulated<\/td> in vitro,\u00a0 Vero E6 (Monkey African Green kidney A subclone of Vero76) cells,\u00a0 A549 [Yu C. et al., 2013]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ICAM1<\/td>intercellular adhesion molecule 1<\/td>3383<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
ICAM1<\/em><\/td> intercellular adhesion molecule 1<\/td> 3383<\/a><\/td> CD54<\/td> [Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Dal\u2019negorsk strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vitro, monocytes [Krylova NV et al., 2015]<\/td> <\/tr>
[Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Primorye-183 strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vitro, monocytes, granulocytes [Krylova NV et al., 2015]<\/td> <\/tr>
[R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td> <\/tr>
[Moniuszko A et al., 2012]<\/td> 22705151<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, cerebrospinal fluid (CSF) [Moniuszko A et al., 2012]<\/td> <\/tr>
[Pietruczuk M et al., 2006]<\/td> 16909787<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, cerebrospinal fluid (CSF) and serum [Pietruczuk M et al., 2006]<\/td> <\/tr>
[Zajkowska JM al.,\u00a0 2005]<\/td> 16245421<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein in stress granules<\/td> Expression was upregulated<\/td> in vivo, cerebrospinal fluid (CSF) [Zajkowska JM al.,\u00a0 2005]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ICAM2<\/td>intercellular adhesion molecule 2<\/td>3384<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
ICAM2<\/em><\/td> intercellular adhesion molecule 2<\/td> 3384<\/a><\/td> <\/td> [Zajkowska JM al.,\u00a0 2005]<\/td> 16245421<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo,\u00a0 serum [Zajkowska JM al.,\u00a0 2005]<\/td> <\/tr>
[Pietruczuk M et al., 2006]<\/td> 16909787<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, cerebrospinal fluid (CSF) [Pietruczuk M et al., 2006]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ICAM3<\/td>intercellular adhesion molecule 3\u00a0<\/td>3385<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
ICAM3<\/em><\/td> intercellular adhesion molecule 3<\/td> 3385<\/a><\/td> <\/td> [Zajkowska JM al.,\u00a0 2005]<\/td> 16245421<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, cerebrospinal fluid (CSF) [Zajkowska JM al.,\u00a0 2005]<\/td> <\/tr>
[Pietruczuk M et al., 2006]<\/td> 16909787<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, cerebrospinal fluid (CSF) and serum [Pietruczuk M et al., 2006]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IFIH1<\/td>interferon induced with helicase C domain 1<\/td>64135<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IFIH1<\/em><\/td> interferon induced with helicase C domain 1<\/td> 64135<\/a><\/td> MDA5<\/td> [Zhang X et al., 2016]<\/td> 27576490<\/a><\/td> TBEV, Far Eastern strain<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vitro: Human\u00a0 T98G cells [Zhang X et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IFIT1<\/td>interferon induced protein with tetratricopeptide repeats 1<\/td>3434<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IFIT1<\/em><\/td> interferon induced protein with tetratricopeptide repeats 1<\/td> 3434<\/a><\/td> IFI-56K<\/td> [Gavrilov BG et al., 2003]<\/td> 12708317<\/a><\/td> TBEV (strain 205)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, Human embryonic kidney cell line RH Infected with Tick-borne Encephalitis Virus [Gavrilov BG et al., 2003]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IFIT2<\/td>interferon induced protein with tetratricopeptide repeats 2 <\/td>3433<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IFIT2<\/em><\/td> interferon induced protein with tetratricopeptide repeats 2<\/td> 3433<\/a><\/td> IFI-54k<\/td> [Gavrilov BG et al., 2003]<\/td> 12708317<\/a><\/td> TBEV (strain 205)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, Human embryonic kidney cell line RH Infected with Tick-borne Encephalitis Virus [Gavrilov BG et al., 2003]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IFNA1<\/td>interferon alpha 1<\/td>3439<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IFNA1<\/em><\/td> interferon alpha 1<\/td> 3439<\/a><\/td> IFN-a, interferon alpha<\/td> [Palus M et al., 2014a]<\/td> 25000960<\/a><\/td> TBEV (strain Neudoerfl)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td> <\/tr>
[Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IFNA2<\/td>interferon alpha 2<\/td>3440<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IFNA2<\/em><\/td> interferon alpha 2<\/td> 3440<\/a><\/td> <\/td> [Lindqvist R et al., 2016]<\/td> 27776548<\/a><\/td> TBEV<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro,\u00a0 Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IFNAR1 <\/td>interferon alpha and beta receptor subunit 1<\/td>3454<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IFNAR1<\/em><\/td> interferon alpha and beta receptor subunit 1<\/td> 3454<\/a><\/td> <\/td> [Lubick KJ et al., 2015]<\/td> 26159719<\/a><\/td> TBEV (Sofjin strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vitro, HEK293 (Human Embryonic Kidney) cells [Lubick KJ et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IFNB1<\/td>interferon beta 1<\/td>3456<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IFNB1<\/em><\/td> interferon beta 1<\/td> 3456<\/a><\/td> <\/td> [Lindqvist R et al., 2016]<\/td> 27776548<\/a><\/td> TBEV<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro,\u00a0 Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]<\/td> <\/tr>
[Grygorczuk S et al., 2015]<\/td> 25461390<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, CSF and serum [Grygorczuk S et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IFNG<\/td>interferon gamma<\/td>3458<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IFNG<\/em><\/td> interferon gamma<\/td> 3458<\/a><\/td> \u00a0IFN-\u03b3<\/td> [Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td> <\/tr>
[Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo,\u00a0 plasma [Blom K et al., 2016]<\/td> <\/tr>
[Aberle JH et al., 2015]<\/td> 26465323<\/a><\/td> TBEV<\/td> TBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, TBEV-specific polyfunctional human CD4+ T cells (L-2+IFN-\u03b3+) [Aberle JH et al., 2015]<\/td> <\/tr>
[R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td> <\/tr>
[Gomez I et al., 2003]<\/td> 14583154<\/a><\/td> TBEV (vaccine against TBE)<\/td> E protein (trancated)<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, CD4+ T lymphocytes\u00a0 specific for E protein\u00a0 from healthy blood donors vaccinated against TBEV with FSME\u00ae-IMMUN Inject (Baxter IMMUNO, Austria) [Gomez I et al., 2003]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IFNL3<\/td>interferon lambda 3<\/td>282617<\/a><\/td>0<\/td>1<\/a>
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IFNL3<\/em><\/td> interferon lambda 3<\/td> 282617<\/a><\/td> IL28B<\/td> [Grygorczuk S et al., 2015]<\/td> 25461391<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, CSF [Grygorczuk S et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		SNP ID<\/th> Reference<\/th> PMID<\/th> SNP location<\/th> Population<\/th> Phenotypic trait caused
by allelic variants<\/th> <\/tr>
IFNL3<\/em><\/td> interferon lambda 3<\/td> 282617<\/a><\/td> IL28B<\/td> rs8103142<\/a><\/td> [Barkhash AV et al. 2016]<\/td> 27068548<\/a><\/td> IFNL3, exon 2, Lys70Arg or exon 3, Lys74Arg<\/td> Russian population from Novosibirsk<\/td> Predisposition to TBE in Russian population [Barkhash AV et al. 2016]<\/td> <\/tr>
rs12980275<\/a><\/td> [Barkhash AV et al. 2016]<\/td> 27068548<\/a><\/td> IFNL3,\u00a0 3'-flanking region<\/td> Russian population from Novosibirsk<\/td> Predisposition to TBE in Russian population [Barkhash AV et al. 2016]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div> <\/div> <\/td>0<\/td>0<\/td>\n<\/tr>\n
IFNL4<\/td>interferon lambda 4 (gene\/pseudogene)<\/td>101180976<\/a><\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		SNP ID<\/th> Reference<\/th> PMID<\/th> SNP location<\/th> Population<\/th> Phenotypic trait caused
by allelic variants<\/th> <\/tr>
IFNL4<\/em><\/td> interferon lambda 4 (gene\/pseudogene)<\/td> 101180976<\/a><\/td> <\/td> rs12979860<\/a><\/td> [Grygorczuk S et al., 2015]<\/td> 25461389<\/a><\/td> IFNL4, first intron<\/td> Polish population<\/td> IFNL3 concentration in CSF in TBE patients [Grygorczuk S et al., 2015]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div> <\/div> <\/td>0<\/td>0<\/td>\n<\/tr>\n
IKZF2<\/td>IKAROS family zinc finger 2<\/td>22807<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IKZF2<\/em><\/td> IKAROS family zinc finger 2<\/td> 22807<\/a><\/td> Helios<\/td> [Blom K et al., 2015]<\/td> 25611738<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> In vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL10<\/td>interleukin 10<\/td>3586<\/a><\/td>0<\/td>1<\/a>
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL10<\/em><\/td> interleukin 10<\/td> 3586<\/a><\/td> <\/td> [Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td> <\/tr>
[Grygorczuk S et al., 2015]<\/td> 25461389<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, CSF and serum [Grygorczuk S et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>1<\/a>
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		SNP ID<\/th> Reference<\/th> PMID<\/th> SNP location<\/th> Population<\/th> Phenotypic trait caused
by allelic variants<\/th> <\/tr>
IL10<\/em><\/td> interleukin 10<\/td> 3586<\/a><\/td> <\/td> rs1800872<\/a><\/td> [Barkhash AV et al. 2016]<\/td> 27068548<\/a><\/td> IL10, promoter region<\/td> Russian population from Novosibirsk<\/td> Predisposition to TBE in Russian population [Barkhash AV et al. 2016]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div> <\/div> <\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		In vivo\/
in vitro<\/th> 		Host
organism<\/th> 		Effect<\/th> Experiment<\/th> <\/tr>
IL10<\/em><\/td> interleukin 10<\/td> 3586<\/a><\/td> IL-10<\/td> [Tun MM et al., 2014]<\/td> 24938868<\/a><\/td> TBEV, Oshima strain<\/td> in vivo<\/td> mouse<\/td> Increased mortality rates [Tun MM et al., 2014]<\/td> Mice were infected subcutaneously with 104 pfu of Oshima strains and were monitored daily\u00a0\u00a0 [Tun MM et al., 2014]<\/td><\/tr><\/table><\/div> Close<\/a> <\/div> <\/div><\/td>\n<\/tr>\n
IL12A<\/td>interleukin 12A<\/td>3592<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL12A<\/em><\/td> interleukin 12A<\/td> 3592<\/a><\/td> <\/td> [Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL12B<\/td>interleukin 12B<\/td>3593<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL12B<\/em><\/td> interleukin 12B<\/td> 3593<\/a><\/td> <\/td> [Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL15<\/td>interleukin 15<\/td>3600<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL15<\/em><\/td> interleukin 15<\/td> 3600<\/a><\/td> <\/td> [Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL16<\/td>interleukin 16<\/td>3603<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
IL16<\/em><\/td> interleukin 16<\/td> 3603<\/a><\/td> <\/td> [Melik W et al., 2012]<\/td> 22796133<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Melik W et al., 2012]<\/td> in vitro, in vitro, PDZ array membranes [Melik W et al., 2012]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL18<\/td>interleukin 18<\/td>3606<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL18<\/em><\/td> interleukin 18<\/td> 3606<\/a><\/td> <\/td> [Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL1A<\/td>interleukin 1 alpha<\/td>3552<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL1A<\/em><\/td> interleukin 1 alpha<\/td> 3552<\/a><\/td> <\/td> [Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL1B<\/td>interleukin 1 beta<\/td>3553<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL1B<\/em><\/td> interleukin 1 beta<\/td> 3553<\/a><\/td> <\/td> [Palus M et al., 2014a]<\/td> 25000960<\/a><\/td> TBEV (strain Neudoerfl)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td> <\/tr>
[Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL2<\/td>interleukin 2<\/td>3558<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL2<\/em><\/td> interleukin 2<\/td> 3558<\/a><\/td> <\/td> [Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td> <\/tr>
[Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, NK cells and\u00a0 plasma [Blom K et al., 2016]<\/td> <\/tr>
[Aberle JH et al., 2015]<\/td> 26465323<\/a><\/td> TBEV<\/td> TBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vivo, TBEV-specific polyfunctional human CD4+ T cells [Aberle JH et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL2RA<\/td>interleukin 2 receptor subunit alpha<\/td>3559<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL2RA<\/em><\/td> interleukin 2 receptor subunit alpha<\/td> 3559<\/a><\/td> CD25<\/td> [Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Dal\u2019negorsk strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vitro, NK cells [Krylova NV et al., 2015]<\/td> <\/tr>
[Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Primorye-183 strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vitro, CD8 T-lymphocytes [Krylova NV et al., 2015]<\/td> <\/tr>
[Fujii Y et al., 2011]<\/td> 21830901<\/a><\/td> TBEV Oshima 5-10 strain<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL4<\/td>interleukin 4 <\/td>3565<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL4<\/em><\/td> interleukin 4<\/td> 3565<\/a><\/td> <\/td> [Tun MM et al., 2014]<\/td> 24938868<\/a><\/td> TBEV, Oshima strain, Sofjin strain<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was downregulated<\/td> In vivo, spleen [Tun MM et al., 2014]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL5<\/td>interleukin 5<\/td>3567<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL5<\/em><\/td> interleukin 5<\/td> 3567<\/a><\/td> <\/td> [Gomez I et al., 2003]<\/td> 14583154<\/a><\/td> TBEV (vaccine against TBE)<\/td> E protein (trancated)<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, CD4+ T lymphocytes\u00a0 specific for E protein\u00a0 from healthy blood donors vaccinated against TBEV with FSME\u00ae-IMMUN Inject (Baxter IMMUNO, Austria) [Gomez I et al., 2003]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL6<\/td>interleukin 6<\/td>3569<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL6<\/em><\/td> interleukin 6<\/td> 3569<\/a><\/td> <\/td> [Palus M et al., 2014a]<\/td> 25000960<\/a><\/td> TBEV (strain Neudoerfl)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td> <\/tr>
[Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td> <\/tr>
[Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo,\u00a0 plasma [Blom K et al., 2016]<\/td> <\/tr>
[R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IL7R<\/td>interleukin 7 receptor <\/td>3575<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IL7R<\/em><\/td> interleukin 7 receptor<\/td> 3575<\/a><\/td> CD127<\/td> [Blom K et al., 2015]<\/td> 25611738<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IRF1<\/td>interferon regulatory factor 1<\/td>3659<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IRF1<\/em><\/td> interferon regulatory factor 1<\/td> 3659<\/a><\/td> <\/td> [Robertson SJ et al., 2014]<\/td> 24532583<\/a><\/td> TBEV (Sofjin strain)<\/td> TBEV<\/td> Mouse<\/td> protein<\/td> Expression was downregulated<\/td> in vitro, bone-marrow derived dendritic cells [Robertson SJ et al., 2014]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
IRF3<\/td>interferon regulatory factor 3<\/td>3661<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
IRF3<\/em><\/td> interferon regulatory factor 3<\/td> 3661<\/a><\/td> <\/td> [Zhang X et al., 2016]<\/td> 27576490<\/a><\/td> TBEV, Far Eastern strain<\/td> TBEV<\/td> Human<\/td> protein (phosphorylated)<\/td> Phosphorilation was upregulated<\/td> in vitro: Human\u00a0 T98G cells [Zhang X et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ITGA3<\/td>integrin subunit alpha 3<\/td>3675<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
ITGA3<\/em><\/td> integrin subunit alpha 3<\/td> 3675<\/a><\/td> 210 kD polypeptide, alpha 3-chain of human integrin<\/td> [Protopopova EV et al., 1997]<\/td> 9499239<\/a><\/td> TBEV<\/td> Human<\/td> TBEV virion [Protopopova EV et al., 1997]<\/td> in vitro,\u00a0 human embryonic renal cells, affinity chromatography with polyclonal antiidiotypic antibodies (AIA) as antireceptor antibodies [Protopopova EV et al., 1997]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ITGAM<\/td>integrin subunit alpha M<\/td>3684<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
ITGAM<\/em><\/td> integrin subunit alpha M<\/td> 3684<\/a><\/td> CD11b<\/td> [Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Dal\u2019negorsk strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vitro, monocytes [Krylova NV et al., 2015]<\/td> <\/tr>
[Krylova NV et al., 2015]<\/td> 25695407<\/a><\/td> TBEV (Primorye-183 strain)<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vitro, monocytes, granulocytes, and NK cells [Krylova NV et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ITGB3<\/td>integrin subunit beta 3<\/td>3690<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
ITGB3<\/em><\/td> integrin subunit beta 3<\/td> 3690<\/a><\/td> \u03b1V\u03b23\u2013integrin<\/td> [Zaitsev BN et al., 2014]<\/td> 25319621<\/a><\/td> TBEV<\/td> Human<\/td> E protein\u00a0 [Zaitsev BN et al., 2014],<\/td> in vitro, enzyme immunoassay and optical surface waves-based biosensor measurements [Zaitsev BN et al., 2014]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
JAG1<\/td>jagged 1<\/td>182<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
JAG1<\/em><\/td> jagged 1<\/td> 182<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
KAT5<\/td>lysine acetyltransferase 5<\/td>10524<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
KAT5<\/em><\/td> lysine acetyltransferase 5<\/td> 10524<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
LAMB1<\/td>laminin subunit beta 1<\/td>3912<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
LAMB1<\/em><\/td> laminin subunit beta 1<\/td> 3912<\/a><\/td> beta 1-chain of human integrin (110 kD)<\/td> [Protopopova EV et al., 1997]<\/td> 9499239<\/a><\/td> TBEV<\/td> Human<\/td> TBEV virion [Protopopova EV et al., 1997]<\/td> in vitro,\u00a0 human embryonic renal cells, affinity chromatography with polyclonal antiidiotypic antibodies (AIA) as antireceptor antibodies [Protopopova EV et al., 1997]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
LAMB2<\/td>laminin subunit beta 2<\/td>3913<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
LAMB2<\/em><\/td> laminin subunit beta 2<\/td> 3913<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
LILRA4<\/td>leukocyte immunoglobulin like receptor A4<\/td>23547<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
LILRA4<\/em><\/td> leukocyte immunoglobulin like receptor A4<\/td> 23547<\/a><\/td> ILT7<\/td> [Dillmann C et al., 2016]<\/td> 26783340<\/a><\/td> TBEV (FSME-IMMUN -inactivated whole virus vaccine against TBE)<\/td> FSME-IMMUN -inactivated whole virus vaccine against TBE<\/td> Human<\/td> protein (cell surface)<\/td> Expression was downregulated<\/td> in vitro, human plasmacytoid dendritic cells (pDCs) [Dillmann C et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
LTF<\/td>lactotransferrin<\/td>4057<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
LTF<\/em><\/td> lactotransferrin<\/td> 4057<\/a><\/td> <\/td> [Merzeniuk ZA et al., 2003]<\/td> 12774664<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, liquor and blood of patients with\u00a0tick-borne encephalitis [Merzeniuk ZA et al., 2000]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
MAGI2<\/td>membrane associated guanylate kinase, WW and PDZ domain containing 2<\/td>9863<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
MAGI2<\/em><\/td> membrane associated guanylate kinase, WW and PDZ domain containing 2<\/td> 9863<\/a><\/td> <\/td> [Ellencrona K et al., 2009]<\/td> 19199833<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Ellencrona K et al., 2009]<\/td> in vitro, PDZ array membranes [Ellencrona K et al., 2009]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
MAVS<\/td>mitochondrial antiviral signaling protein<\/td>57506<\/a><\/td>0<\/td>0<\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		In vivo\/
in vitro<\/th> 		Host
organism<\/th> 		Effect<\/th> Experiment<\/th> <\/tr>
MAVS<\/em><\/td> mitochondrial antiviral signaling protein<\/td> 57506<\/a><\/td> IPS-1<\/td> [Kurhade C et al., 2016]<\/td> 26819220<\/a><\/td> TBEV strain Hypr<\/td> in vivo<\/td> mouse<\/td> Decreased median survival time [Kurhade C et al., 2016]<\/td> Six- to ten-weekold mice were intraperitoneally infected with\u00a0 TBEV\u00a0 [Kurhade C et al., 2016]<\/td><\/tr><\/table><\/div> Close<\/a> <\/div> <\/div> <\/td>\n<\/tr>\n
MKI67<\/td>marker of proliferation Ki-67<\/td>4288<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
MKI67<\/em><\/td> marker of proliferation Ki-67<\/td> 4288<\/a><\/td> Ki67<\/td> [Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, human NK cells in response to\u00a0TBEV\u00a0infection [Blom K et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
MLPH<\/td>melanophilin<\/td>79083<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
MLPH<\/em><\/td> melanophilin<\/td> 79083<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
MMP9<\/td>matrix metallopeptidase 9<\/td>4318<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
MMP9<\/em><\/td> matrix metallopeptidase 9<\/td> 4318<\/a><\/td> <\/td> [Palus M et al., 2014a]<\/td> 25000960<\/a><\/td> TBEV (strain Neudoerfl)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td> <\/tr>
[Palus M et al., 2014b]<\/td> 25000960<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, serum [Palus M et al., 2014b]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
MYH9<\/td>myosin heavy chain 9<\/td>4627<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
MYH9<\/em><\/td> myosin heavy chain 9<\/td> 4627<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
NQO1<\/td>NAD(P)H quinone dehydrogenase 1<\/td>1728<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
NQO1<\/em><\/td> NAD(P)H quinone dehydrogenase 1<\/td> 1728<\/a><\/td> <\/td> [Kuzmenko YV et al., 2016a]<\/td> 27875810<\/a><\/td> TBEV<\/td> NS1<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, HEK 293T cells (Human Embryonic Kidney 293 transformed with large T antigen), RT-qPCR [Kuzmenko YV et al., 2016a]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
OAS1<\/td>2'-5'-oligoadenylate synthetase 1<\/td>4938<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
OAS1<\/em><\/td> 2'-5'-oligoadenylate synthetase 1<\/td> 4938<\/a><\/td> <\/td> [Yoshii K et al., 2013]<\/td> 23266832<\/a><\/td> TBEV (Sofjin-HO or Oshima 5-10 strain)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Yoshii K et al., 2013]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
OAS2<\/td>2'-5'-oligoadenylate synthetase 2 <\/td>4939<\/a><\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		SNP ID<\/th> Reference<\/th> PMID<\/th> SNP location<\/th> Population<\/th> Phenotypic trait caused
by allelic variants<\/th> <\/tr>
OAS2<\/em><\/td> 2'-5'-oligoadenylate synthetase 2<\/td> 4939<\/a><\/td> <\/td> rs1293762<\/a><\/td> [Barkhash AV et al., 2010]<\/td> 21050126<\/a><\/td> OAS2, intron 2<\/td> Russian population from Novosibirsk<\/td> The outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]<\/td> <\/tr>
rs15895<\/a><\/td> [Barkhash AV et al., 2010]<\/td> 21050126<\/a><\/td> OAS2, 3'-UTR \/ exon 11, Trp720Stop<\/td> Russian population from Novosibirsk<\/td> The outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]<\/td> <\/tr>
rs1732778<\/a><\/td> [Barkhash AV et al., 2010]<\/td> 21050126<\/a><\/td> OAS2, 3'-flanking region<\/td> Russian population from Novosibirsk<\/td> The outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div> <\/div> <\/td>0<\/td>0<\/td>\n<\/tr>\n
OAS3<\/td>2'-5'-oligoadenylate synthetase 3<\/td>4040<\/a><\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		SNP ID<\/th> Reference<\/th> PMID<\/th> SNP location<\/th> Population<\/th> Phenotypic trait caused
by allelic variants<\/th> <\/tr>
OAS3<\/em><\/td> 2'-5'-oligoadenylate synthetase 3<\/td> 4940<\/a><\/td> <\/td> rs2285932<\/a><\/td> [Barkhash AV et al., 2010]<\/td> 21050126<\/a><\/td> OAS3, exon 6, Ile438Ile<\/td> Russian population from Novosibirsk<\/td> The outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]<\/td> <\/tr>
rs2072136<\/a><\/td> [Barkhash AV et al., 2010]<\/td> 21050126<\/a><\/td> OAS3, exon 8, Ser567Ser<\/td> Russian population from Novosibirsk<\/td> The outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div> <\/div> <\/td>0<\/td>0<\/td>\n<\/tr>\n
PDCD1<\/td>programmed cell death 1<\/td>5133<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
PDCD1<\/em><\/td> programmed cell death 1<\/td> 5133<\/a><\/td> PD-1<\/td> [Blom K et al., 2015]<\/td> 25611738<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo,\u00a0 CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
PDE4DIP<\/td>phosphodiesterase 4D interacting protein<\/td>9659<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
PDE4DIP<\/em><\/td> phosphodiesterase 4D interacting protein<\/td> 9659<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
PDLIM4<\/td>PDZ and LIM domain 4<\/td>8572<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
PDLIM4<\/em><\/td> PDZ and LIM domain 4<\/td> 8572<\/a><\/td> <\/td> [Ellencrona K et al., 2009]<\/td> 19199833<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Ellencrona K et al., 2009]<\/td> in vitro, PDZ array membranes [Ellencrona K et al., 2009]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
PEPD<\/td>peptidase D<\/td>5184<\/a><\/td>1<\/a>
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
PEPD<\/em><\/td> peptidase D<\/td> 5184<\/a><\/td> <\/td> [Lubick KJ et al., 2015]<\/td> 26159719<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Lubick KJ et al., 2015]<\/td> In vitro, Human Embryonic Kidney 293 (HEK293) cells, Immunoblot analysis following co\u2010IP(immunoprecipitation) of flavivirus NS5 and PEPD\u2010GFP [Lubick KJ et al., 2015]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		Other
essential
protein<\/th> 		References<\/th> PMID<\/th> Type of
interaction<\/th> 		Virus, strain<\/th> Host organism<\/th> In vivo\/in vitro<\/th> <\/tr>
PEPD<\/em><\/td> peptidase D<\/td> 5184<\/a><\/td> <\/td> IFNAR1<\/td> [Lubick KJ et al., 2015]<\/td> 26159719<\/a><\/td> Interaction within pathway<\/td> TBEV (strain Sofjin)<\/td> Human<\/td> in vitro, HEK293 (Human Embryonic Kidney). In vivo, human fibroblasts<\/td><\/tr><\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>\n<\/tr>\n
PHAX<\/td>phosphorylated adaptor for RNA export<\/td>51808<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
PHAX<\/em><\/td> phosphorylated adaptor for RNA export<\/td> 51808<\/a><\/td> RNUXA<\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
PHC2<\/td>polyhomeotic homolog 2<\/td>1912<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
PHC2<\/em><\/td> polyhomeotic homolog 2<\/td> 1912<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
PRF1<\/td>perforin 1<\/td>5551<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
PRF1<\/em><\/td> perforin 1<\/td> 5551<\/a><\/td> <\/td> [Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was downregulated<\/td> in vivo, human NK cells in response to\u00a0TBEV\u00a0infection [Blom K et al., 2016]<\/td> <\/tr>
[Blom K et al., 2015]<\/td> 25611738<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo,\u00a0 CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]<\/td> <\/tr>
PRF1<\/em><\/td> perforin 1<\/td> 5551<\/a><\/td> <\/td> [Fujii Y et al., 2011]<\/td> 21830901<\/a><\/td> TBEV Oshima 5-10 strain<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td> <\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
PSMB10<\/td>proteasome subunit beta 10<\/td>5699<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
PSMB10<\/em><\/td> proteasome subunit beta 10<\/td> 5699<\/a><\/td> <\/td> [Kuzmenko YV et al., 2016b]<\/td> 27239857<\/a><\/td> TBEV (Western subtype)<\/td> NS1<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, HeLa [Kuzmenko YV et al., 2016b]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
PSMB8<\/td>proteasome subunit beta 8<\/td>5696<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
PSMB8<\/em><\/td> proteasome subunit beta 8<\/td> 5696<\/a><\/td> <\/td> [Kuzmenko YV et al., 2016b]<\/td> 27239857<\/a><\/td> TBEV (Western subtype)<\/td> NS1<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, HeLa [Kuzmenko YV et al., 2016b]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
RAC1<\/td>ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)<\/td>5879<\/a><\/td>0<\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		Other
essential
protein<\/th> 		References<\/th> PMID<\/th> Type of
interaction<\/th> 		Virus, strain<\/th> Host organism<\/th> In vivo\/in vitro<\/th> <\/tr>
RAC1<\/em><\/td> ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)<\/td> 5879<\/a><\/td> <\/td> SCRIB<\/td> [Wigerius M et al., 2010]<\/td> 20363326<\/a><\/td> Physical\u00a0 interactions with important protein<\/td> TBEV<\/td> Human<\/td> in vitro, PC12 cells derived from a rat pheochromocytoma,\u00a0 COS-7 (fibroblast-like cell lines derived from monkey kidney tissue)\u00a0\u00a0 [Wigerius M et al., 2010].<\/td><\/tr><\/table><\/div> Close<\/a> <\/div> <\/div><\/td>0<\/td>\n<\/tr>\n
RIMS2<\/td>regulating synaptic membrane exocytosis 2<\/td>9699<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
RIMS2<\/em><\/td> regulating synaptic membrane exocytosis 2<\/td> 9699<\/a><\/td> <\/td> [Ellencrona K et al., 2009]<\/td> 19199833<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Ellencrona K et al., 2009]<\/td> in vitro, PDZ array membranes [Ellencrona K et al., 2009]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
RNF125<\/td>ring finger protein 12<\/td>54941<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
RNF125<\/em><\/td> ring finger protein 12<\/td> 54941<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
RPSA<\/td>ribosomal protein SA<\/td>3921<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
RPSA<\/em><\/td> ribosomal protein SA<\/td> 3921<\/a><\/td> LBP, 67 kD laminin receptor, LamR1, laminin receptor 1<\/td> [Protopopova EV et al., 1997]<\/td> 9499239<\/a><\/td> TBEV<\/td> Human<\/td> TBEV virion [Protopopova EV et al., 1997]<\/td> in vitro, human embryonic renal cells, affinity chromatography with polyclonal antiidiotypic antibodies (AIA) as antireceptor antibodies [Protopopova EV et al., 1997]<\/td> <\/tr>
LBP, 67 kD laminin receptor, LamR1, laminin receptor 2<\/td> [Malygin AA et al., 2009]<\/td> 19961413<\/a><\/td> TBEV<\/td> Human<\/td> E protein [Malygin AA et al., 2009]<\/td> in vitro,\u00a0 enzyme immunoassay and immunoblotting\u00a0 [Malygin AA et al., 2009]<\/td> <\/tr>
LBP, 67 kD laminin receptor, LamR1, laminin receptor 3<\/td> [Zaitsev BN et al., 2014]<\/td> 25319621<\/a><\/td> TBEV<\/td> Human<\/td> E protein [Zaitsev BN et al., 2014]<\/td> in vitro,\u00a0 combined methods of single-molecule dynamic force spectroscopy (SMDFS), enzyme immunoassay and optical surface waves-based biosensor measurements [Zaitsev BN et al., 2014]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
RSAD2<\/td>radical S-adenosyl methionine domain containing 2<\/td>91543<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
RSAD2<\/em><\/td> radical S-adenosyl methionine domain containing 2<\/td> 91543<\/a><\/td> Viperin<\/td> [Lindqvist R et al., 2016]<\/td> 27776548<\/a><\/td> TBEV<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro,\u00a0 Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
S1PR4<\/td>sphingosine-1-phosphate receptor 4 <\/td>8698<\/a><\/td>0<\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		Other
essential
protein<\/th> 		References<\/th> PMID<\/th> Type of
interaction<\/th> 		Virus, strain<\/th> Host organism<\/th> In vivo\/in vitro<\/th> <\/tr>
S1PR4<\/em><\/td> sphingosine-1-phosphate receptor 4<\/td> 8698<\/a><\/td> <\/td> LILRA4<\/td> [Dillmann C et al., 2016]<\/td> 26783340<\/a><\/td> Interaction within pathway<\/td> TBEV (FSME-IMMUN -inactivated whole virus vaccine against TBE)<\/td> Human<\/td> in vitro, human plasmacytoid dendritic cells (pDCs)<\/td><\/tr><\/table><\/div> Close<\/a> <\/div> <\/div> <\/td>0<\/td>\n<\/tr>\n
SCRIB<\/td>scribbled planar cell polarity protein<\/td>23513<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
SCRIB<\/em><\/td> scribbled planar cell polarity protein<\/td> 23513<\/a><\/td> <\/td> [Ellencrona K et al., 2009]<\/td> 19199833<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Ellencrona K et al., 2009]<\/td> in vitro, PDZ array membranes [Ellencrona K et al., 2009]<\/td> <\/tr>
[Werme K\u00a0 et al., 2008]<\/td> 18042258<\/a><\/td> TBEV<\/td> in vitro,\u00a0 yeast two-hybrid (Y2H) screen against a human brain cDNA library\u00a0 [Werme K\u00a0 et al 2008]<\/td> Human<\/td> NS5 [Werme K\u00a0 et al., 2008]<\/td> <\/tr>
[Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
SMARCB1<\/td>SWI\/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1<\/td>6598<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
SMARCB1<\/em><\/td> SWI\/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1<\/td> 6598<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
SOCS1<\/td>suppressor of cytokine signaling 1<\/td>8651<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
SOCS1<\/em><\/td> suppressor of cytokine signaling 1<\/td> 8651<\/a><\/td> <\/td> [Mansfield KL et al., 2010]<\/td> 20854017<\/a><\/td> TBEV, strain Neudoerfl<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
SOCS3<\/td>suppressor of cytokine signaling 3<\/td>9021<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
SOCS3<\/em><\/td> suppressor of cytokine signaling 3<\/td> 9021<\/a><\/td> <\/td> [Mansfield KL et al., 2010]<\/td> 20854017<\/a><\/td> TBEV, strain Neudoerfl<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
SPDL1<\/td>spindle apparatus coiled-coil protein 1<\/td>54908<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
SPDL1<\/em><\/td> spindle apparatus coiled-coil protein 1<\/td> 54908<\/a><\/td> CCDC99<\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
TAF15<\/td>TATA-box binding protein associated factor 15<\/td>8148<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
TAF15<\/em><\/td> TATA-box binding protein associated factor 15<\/td> 8148<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
TBK1<\/td>TANK binding kinase 1<\/td>29110<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
TBK1<\/em><\/td> TANK binding kinase 1<\/td> 29110<\/a><\/td> <\/td> [Zhang X et al., 2016]<\/td> 27576490<\/a><\/td> TBEV, Far Eastern strain<\/td> TBEV<\/td> Human<\/td> protein (phosphorylated)<\/td> Phosphorilation was upregulated<\/td> in vitro: Human\u00a0 T98G cells [Zhang X et al., 2016]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
TBX21<\/td>T-box 21<\/td>30009<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
TBX21<\/em><\/td> T-box 21<\/td> 30009<\/a><\/td> Tbet, T-bet<\/td> [Aberle JH et al., 2015]<\/td> 26465323<\/a><\/td> TBEV<\/td> TBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo, TBEV-specific polyfunctional human CD4+ T cells (L-2+IFN-\u03b3+) [Aberle JH et al., 2015]<\/td> <\/tr>
[Blom K et al., 2015]<\/td> 25611738<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo,\u00a0 CD8 T cells from TBEV infected patients [Blom K et al., 2015]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
TIA1<\/td>TIA1 cytotoxic granule associated RNA binding protein<\/td>7072<\/a><\/td>1<\/a>
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
TIA1<\/em><\/td> TIA1 cytotoxic granule associated RNA binding protein<\/td> 7072<\/a><\/td> <\/td> [Albornoz A et al., 2014]<\/td> 24696465<\/a><\/td> TBEV<\/td> Human<\/td> RNA [Albornoz A et al., 2014]<\/td> in vitro, human U2OS (Human Bone Osteosarcoma Epithelial Cells) cells, Immunofluorescence, and immunoblot analyses [Albornoz A et al., 2014]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		In vivo\/
in vitro<\/th> 		Host
organism<\/th> 		Effect<\/th> Experiment<\/th> <\/tr>
TIA1<\/em><\/td> TIA1 cytotoxic granule associated RNA binding protein<\/td> 7072<\/a><\/td> TIA-1<\/td> [Albornoz A et al., 2014]<\/td> 24696465<\/a><\/td> TBEV, strain Neudoerfl<\/td> in vitro, mouse embryonic fibroblast (MEF)<\/td> mouse<\/td> Increase in TBEV extracellular infectivity [Albornoz A et al., 2014]<\/td> MEF TIA-1\u2212\/\u2212 or their control (MEF WT) were infected with TBEV at an MOI of 2. Cell supernatant collected 24 and 48 h p.i. was used to infect Vero cells to measure virus yields (PFU\/ml) from infected MEF TIA-1\u2212\/\u2212 or infected MEF WT samples<\/td> <\/tr> <\/table> <\/div> Close<\/a><\/div><\/div> <\/td>\n<\/tr>\n
TIAL1<\/td>TIA1 cytotoxic granule associated RNA binding protein like 1<\/td>7073<\/a><\/td>1<\/a>
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
TIAL1<\/em><\/td> TIA1 cytotoxic granule associated RNA binding protein like 1<\/td> 7073<\/a><\/td> TIAR<\/td> [Albornoz A et al., 2014]<\/td> 24696465<\/a><\/td> TBEV<\/td> Human<\/td> RNA [Albornoz A et al., 2014]<\/td> in vitro, human U2OS (Human Bone Osteosarcoma Epithelial Cells) cells, Immunofluorescence, and immunoblot analyses [Albornoz A et al., 2014]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		In vivo\/
in vitro<\/th> 		Host
organism<\/th> 		Effect<\/th> Experiment<\/th> <\/tr>
TIAL1<\/em><\/td> TIA1 cytotoxic granule associated RNA binding protein like 1<\/td> 7073<\/a><\/td> TIAR<\/td> [Albornoz A et al., 2014]<\/td> 24696465<\/a><\/td> TBEV, strain Neudoerfl<\/td> in vitro, mouse embryonic fibroblast (MEF)<\/td> mouse<\/td> Decrease in TBEV extracellular infectivity [Albornoz A et al., 2014]<\/td> MEF TIAR\u2212\/\u2212 or their control (MEF WT) were infected with TBEV at an MOI of 2. Cell supernatant collected 24 and 48 h p.i. was used to infect Vero cells to measure virus yields (PFU\/ml) from infected MEF TIAR\u2212\/\u2212 or infected MEF WT samples<\/td> <\/tr> <\/table> <\/div> Close<\/a><\/div><\/div> <\/td>\n<\/tr>\n
TJP1<\/td>tight junction protein 1<\/td>7082<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
TJP1<\/em><\/td> tight junction protein 1<\/td> 7082<\/a><\/td> <\/td> [Ellencrona K et al., 2009]<\/td> 19199833<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Ellencrona K et al., 2009]<\/td> in vitro, PDZ array membranes, immunochemical analysis,\u00a0 HeLa and MDCK cells [Ellencrona K et al., 2009]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div><\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
TJP2<\/td>tight junction protein 2<\/td>9414<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
TJP2<\/em><\/td> tight junction protein 2<\/td> 9414<\/a><\/td> <\/td> [Melik W et al., 2012]<\/td> 22796133<\/a><\/td> TBEV<\/td> Human<\/td> NS5 [Melik W et al., 2012]<\/td> in vitro, in vitro, PDZ array membranes [Melik W et al., 2012]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
TLR3<\/td>toll like receptor 3<\/td>7098<\/a><\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		SNP ID<\/th> Reference<\/th> PMID<\/th> SNP location<\/th> Population<\/th> Phenotypic trait caused
by allelic variants<\/th> <\/tr>
TLR3<\/em><\/td> toll like receptor 3<\/td> 7098<\/a><\/td> <\/td> rs3775291<\/a><\/td> [Mickien\u0117 A\u00a0 et al., 2014], [Barkhash AV et al., 2013]<\/td> 25226020<\/a>, 23721942<\/a><\/td> TLR3, exon 4, Leu412Phe<\/td> Russian population from Novosibirsk, Lithuanian Population<\/td> Disease severity in adult [Mickien\u0117 A\u00a0 et al., 2014]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div> <\/div> <\/td>0<\/td>0<\/td>\n<\/tr>\n
TLR7<\/td>toll like receptor 7<\/td>51284<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
TLR7<\/em><\/td> toll like receptor 7<\/td> 51284<\/a><\/td> <\/td> [Dillmann C et al., 2016]<\/td> 26783340<\/a><\/td> TBEV (FSME-IMMUN -inactivated whole virus vaccine against TBE)<\/td> Human<\/td> FSME-IMMUN -inactivated whole virus vaccine against TBE [Dillmann C et al., 2016]<\/td> in vitro, human plasmacytoid dendritic cells (pDCs) [Dillmann C et al., 2016]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
TNF<\/td>tumor necrosis factor<\/td>7124<\/a><\/td>0<\/td>1<\/a>
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
TNF<\/em><\/td> tumor necrosis factor<\/td> 7124<\/a><\/td> tumour necrosis factor \u03b1<\/td> [Palus M et al., 2014a]<\/td> 25000960<\/a><\/td> TBEV (strain Neudoerfl)<\/td> TBEV<\/td> Human<\/td> mRNA<\/td> Expression was upregulated<\/td> in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]<\/td> <\/tr>
[Palus M et al., 2013]<\/td> 23805778<\/a><\/td> TBEV ( strain Neudoerfl)<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, mouse (BALB\/c) brain, Real-time quantitative PCR [Palus M et al., 2013]<\/td> <\/tr>
[Blom K et al., 2016]<\/td> 27543616<\/a><\/td> TBEV<\/td> TBEV<\/td> Human<\/td> protein<\/td> Expression was upregulated<\/td> in vivo,\u00a0 plasma [Blom K et al., 2016]<\/td> <\/tr>
TNF<\/em><\/td> tumor necrosis factor<\/td> 7124<\/a><\/td> TNFa<\/td> [R\u016f\u017eek D et al., 2011]<\/td> 21629771<\/a><\/td> TBEV, strain Neudoerfl\/IRE<\/td> TBEV<\/td> Mouse<\/td> mRNA<\/td> Expression was upregulated<\/td> in vivo, brain [Fujii Y et al., 2011]<\/td> <\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		In vivo\/
in vitro<\/th> 		Host
organism<\/th> 		Effect<\/th> Experiment<\/th> <\/tr>
TNF<\/em><\/td> tumor necrosis factor<\/td> 7124<\/a><\/td> TNF-a<\/td> [Tun MM et al., 2014]<\/td> 24938868<\/a><\/td> TBEV, Oshima strain<\/td> in vivo<\/td> mouse<\/td> Increased mortality rates [Tun MM et al., 2014]<\/td> Mice were infected subcutaneously with 104 pfu of Oshima strains and were monitored daily\u00a0\u00a0 [Tun MM et al., 2014]<\/td><\/tr><\/table><\/div> Close<\/a> <\/div> <\/div> <\/td>\n<\/tr>\n
TOM1L1<\/td>target of myb1 like 1 membrane trafficking protein<\/td>10040<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
TOM1L1<\/em><\/td> target of myb1 like 1 membrane trafficking protein<\/td> 10040<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
TRIM21<\/td>tripartite motif containing 21<\/td>6737<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
TRIM21<\/em><\/td> tripartite motif containing 21<\/td> 6737<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
TXNDC9<\/td>thioredoxin domain containing 9<\/td>10190<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
TXNDC9<\/em><\/td> thioredoxin domain containing 9<\/td> 10190<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
TYK2<\/td>tyrosine kinase 2<\/td>7297<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
TYK2<\/em><\/td> tyrosine kinase 2<\/td> 7297<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
VIM<\/td>vimentin<\/td>7431<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
VIM<\/em><\/td> vimentin<\/td> 7431<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
VPS11<\/td>VPS11, CORVET\/HOPS core subunit<\/td>55823<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
VPS11<\/em><\/td> VPS11, CORVET\/HOPS core subunit<\/td> 55823<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
XBP1<\/td>X-box binding protein 1<\/td>7424<\/a><\/td>0<\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known
as<\/th> 		References<\/th> PMID<\/th> Virus,
strain<\/th> 		Inductor
(TBEV or
protein)<\/th> 		Host
organism<\/th> 		mRNA
expression
level
or protein
expression
level<\/th> 		Effect<\/th> Method in vivo\/invitro<\/th> <\/tr>
XBP1<\/em><\/td> X-box binding protein 1<\/td> 7494<\/a><\/td> sXBP1<\/td> [Yu C. et al., 2013]<\/td> 24177270<\/a><\/td> TBEV (strain K23)<\/td> TBEV<\/td> African Green\u00a0 Monkey<\/td> mRNA, protein<\/td> Expression was upregulated<\/td> in vitro,\u00a0 Vero E6 (Monkey African Green kidney A subclone of Vero76) cells,\u00a0 A550 [Yu C. et al., 2013]<\/td><\/tr><\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ZBTB17<\/td>zinc finger and BTB domain containing 17<\/td>7709<\/a><\/td>1<\/a>
\n\t
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
ZBTB17<\/em><\/td> zinc finger and BTB domain containing 17<\/td> 7709<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n
ZCCHC17<\/td>zinc finger CCHC-type containing 17<\/td>51538<\/a><\/td>1<\/a>
EntrezGene
Official
Symbol<\/th> 		Official Full Name<\/th> EntrezGene
Gene ID<\/th> 		Also
known as<\/th> 		References<\/th> PMID<\/th> Virus, strain<\/th> Host
organism<\/th> 		Interactant:
TBEV
virion or viral
proten or
viral RNA<\/th> 		Method<\/th> <\/tr>
ZCCHC17<\/em><\/td> zinc finger CCHC-type containing 17<\/td> 51538<\/a><\/td> <\/td> [Le Breton M et al., 2011]<\/td> 22014111<\/a><\/td> TBEV (strain 263)<\/td> Human<\/td> NS5 [Le Breton M et al., 2011]<\/td> in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]<\/td><\/tr> <\/table><\/div>Close<\/a><\/div><\/div> <\/td>0<\/td>0<\/td>0<\/td>0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/33"}],"collection":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/comments?post=33"}],"version-history":[{"count":1,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/33\/revisions"}],"predecessor-version":[{"id":293,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/33\/revisions\/293"}],"wp:attachment":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/media?parent=33"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}