{"id":67,"date":"2017-08-31T10:01:37","date_gmt":"2017-08-31T07:01:37","guid":{"rendered":"http:\/\/icg.nsc.ru\/encephalitis\/?page_id=27"},"modified":"2017-08-31T10:01:37","modified_gmt":"2017-08-31T07:01:37","slug":"allelic-variant","status":"publish","type":"page","link":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/allelic-variant\/","title":{"rendered":"Allelic variant in this gene was associated with susceptibility or resistance to TBEV infection"},"content":{"rendered":"

All genes were collected from research papers.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
EntrezGene
Official
Symbol<\/th>\n		Official Full Name<\/th>\nEntrezGene
Gene ID<\/th>\n		Also
known as<\/th>\n		SNP ID<\/th>\nReference<\/th>\nPMID<\/th>\nSNP location<\/th>\nPopulation<\/th>\nPhenotypic trait caused by allelic variants<\/th>\n<\/tr>\n
ARID1B<\/em><\/td>\nAT-rich interaction domain 1B<\/td>\n57492<\/a><\/td>\n<\/td>\nrs287886<\/a><\/td>\n[Grygorczuk S et al., 2015]<\/td>\n25461389<\/a><\/td>\nARID1B,\u00a0 first intron<\/td>\nPolish population<\/td>\nIL-10 concentration in CSF in TBE patients [Grygorczuk S et al., 2015]<\/td>\n<\/tr>\n
CCR5<\/em><\/td>\nC-C motif chemokine receptor 5 (gene\/pseudogene)<\/td>\n1234<\/a><\/td>\n<\/td>\nrs333 (CCR5D32)<\/a><\/td>\n[Mickien\u0117 A\u00a0 et al., 2014] [Kindberg E et al., 2008]<\/td>\n25226020<\/a>, 18179389<\/a><\/td>\nCCR5, exon 1 or 2<\/td>\nLithuanian Population<\/td>\nThe prevalence of CCR5D32 homozygotes was higher in TBE patients than in controls (p,0.05) [Mickien\u0117 A et al., 2014]. CCR5 32 allele prevalence increased with the clinical severity of disease\u00a0 [Kindberg E et al., 2008]<\/td>\n<\/tr>\n
CD209<\/em><\/td>\nCD209 molecule<\/td>\n30835<\/a><\/td>\n<\/td>\nrs2287886<\/a><\/td>\n[Barkhash AV et al., 2012]<\/td>\n22061615<\/a><\/td>\nCD209, promoter region<\/td>\nRussian population<\/td>\nPredisposition to severe forms of TBE in the Russian population [Barkhash AV et al., 2012]<\/td>\n<\/tr>\n
IFNL3<\/em><\/td>\ninterferon lambda 3<\/td>\n282617<\/a><\/td>\nIL28B<\/td>\nrs8103142<\/a><\/td>\n[Barkhash AV et al. 2016]<\/td>\n27068548<\/a><\/td>\nIFNL3, exon 2, Lys70Arg or exon 3, Lys74Arg<\/td>\nRussian population from Novosibirsk<\/td>\nPredisposition to TBE in Russian population [Barkhash AV et al. 2016]<\/td>\n<\/tr>\n
rs12980275<\/a><\/td>\n[Barkhash AV et al. 2016]<\/td>\n27068548<\/a><\/td>\nIFNL3,\u00a0 3′-flanking region<\/td>\nRussian population from Novosibirsk<\/td>\nPredisposition to TBE in Russian population [Barkhash AV et al. 2016]<\/td>\n<\/tr>\n
IFNL4<\/em><\/td>\ninterferon lambda 4 (gene\/pseudogene)<\/td>\n101180976<\/a><\/td>\n<\/td>\nrs12979860<\/a><\/td>\n[Grygorczuk S et al., 2015]<\/td>\n25461389<\/a><\/td>\nIFNL4, first intron<\/td>\nPolish population<\/td>\nIFNL3 concentration in CSF in TBE patients [Grygorczuk S et al., 2015]<\/td>\n<\/tr>\n
IL10<\/em><\/td>\ninterleukin 10<\/td>\n3586<\/a><\/td>\n<\/td>\nrs1800872<\/a><\/td>\n[Barkhash AV et al. 2016]<\/td>\n27068548<\/a><\/td>\nIL10, promoter region<\/td>\nRussian population from Novosibirsk<\/td>\nPredisposition to TBE in Russian population [Barkhash AV et al. 2016]<\/td>\n<\/tr>\n
OAS2<\/em><\/td>\n2′-5′-oligoadenylate synthetase 2<\/td>\n4939<\/a><\/td>\n<\/td>\nrs1293762<\/a><\/td>\n[Barkhash AV et al., 2010]<\/td>\n21050126<\/a><\/td>\nOAS2, intron 2<\/td>\nRussian population from Novosibirsk<\/td>\nThe outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]<\/td>\n<\/tr>\n
rs15895<\/a><\/td>\n[Barkhash AV et al., 2010]<\/td>\n21050126<\/a><\/td>\nOAS2, 3′-UTR \/ exon 11, Trp720Stop<\/td>\nRussian population from Novosibirsk<\/td>\nThe outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]<\/td>\n<\/tr>\n
rs1732778<\/a><\/td>\n[Barkhash AV et al., 2010]<\/td>\n21050126<\/a><\/td>\nOAS2, 3′-flanking region<\/td>\nRussian population from Novosibirsk<\/td>\nThe outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]<\/td>\n<\/tr>\n
OAS3<\/em><\/td>\n2′-5′-oligoadenylate synthetase 3<\/td>\n4940<\/a><\/td>\n<\/td>\nrs2285932<\/a><\/td>\n[Barkhash AV et al., 2010]<\/td>\n21050126<\/a><\/td>\nOAS3, exon 6, Ile438Ile<\/td>\nRussian population from Novosibirsk<\/td>\nThe outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]<\/td>\n<\/tr>\n
rs2072136<\/a><\/td>\n[Barkhash AV et al., 2010]<\/td>\n21050126<\/a><\/td>\nOAS3, exon 8, Ser567Ser<\/td>\nRussian population from Novosibirsk<\/td>\nThe outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]<\/td>\n<\/tr>\n
TLR3<\/em><\/td>\ntoll like receptor 3<\/td>\n7098<\/a><\/td>\n<\/td>\nrs3775291<\/a><\/td>\n[Mickien\u0117 A\u00a0 et al., 2014], [Barkhash AV et al., 2013]<\/td>\n25226020<\/a>, 23721942<\/a><\/td>\nTLR3, exon 4, Leu412Phe<\/td>\nRussian population from Novosibirsk, Lithuanian Population<\/td>\nDisease severity in adult [Mickien\u0117 A\u00a0 et al., 2014]<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

All genes were collected from research papers. EntrezGeneOfficialSymbol Official Full Name EntrezGeneGene ID Alsoknown as SNP ID Reference PMID SNP location Population Phenotypic trait caused by allelic variants ARID1B AT-rich interaction domain 1B 57492 rs287886 [Grygorczuk S et al., 2015] 25461389 ARID1B,\u00a0 first intron Polish population IL-10 concentration in CSF in TBE patients [Grygorczuk S…<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/67"}],"collection":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/comments?post=67"}],"version-history":[{"count":0,"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/pages\/67\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.icgbio.ru\/TBEVHostDB\/wp-json\/wp\/v2\/media?parent=67"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}