{"id":606,"date":"2009-03-03T16:31:06","date_gmt":"2009-03-03T10:31:06","guid":{"rendered":"http:\/\/www.bionet.nsc.ru\/labs\/epigenetics\/?p=606"},"modified":"2009-03-03T16:31:06","modified_gmt":"2009-03-03T10:31:06","slug":"journal-club-5-%d0%bc%d0%b0%d1%80%d1%82%d0%b0-%d0%b2-14-00-%d0%b2-%d0%ba%d0%be%d0%bd%d1%84%d0%b5%d1%80%d0%b5%d0%bd%d1%86-%d0%b7%d0%b0%d0%bb%d0%b5","status":"publish","type":"post","link":"https:\/\/sites.icgbio.ru\/epigenetics\/2009\/03\/03\/journal-club-5-%d0%bc%d0%b0%d1%80%d1%82%d0%b0-%d0%b2-14-00-%d0%b2-%d0%ba%d0%be%d0%bd%d1%84%d0%b5%d1%80%d0%b5%d0%bd%d1%86-%d0%b7%d0%b0%d0%bb%d0%b5\/","title":{"rendered":"Journal club 5 \u043c\u0430\u0440\u0442\u0430 \u0432 14-00 \u0432 \u043a\u043e\u043d\u0444\u0435\u0440\u0435\u043d\u0446-\u0437\u0430\u043b\u0435"},"content":{"rendered":"<p><strong>\u041c\u0435\u0434\u0432\u0435\u0434\u0435\u0432 \u0421.\u041f. <\/strong>\u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u0438\u0442 \u0434\u043e\u043a\u043b\u0430\u0434 <strong>\u00ab\u041f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u0435 \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u043f\u043b\u044e\u0440\u0438\u043f\u043e\u0442\u0435\u043d\u0442\u043d\u044b\u0445 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a \u0438\u0437 \u043d\u0435\u0439\u0440\u0430\u043b\u044c\u043d\u044b\u0445 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a \u043c\u044b\u0448\u0438\u00bb.<\/strong><br \/>\n\u0414\u043e\u043a\u043b\u0430\u0434 \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043b\u0435\u043d \u043f\u043e \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430\u043c \u0441\u0442\u0430\u0442\u044c\u0438:<br \/>\nKim J.B., Sebastiano V., Wu G., Arauzo-Bravo M.J., Sasse P., Gentile L., Ko K., Ruau D., Ehrich M., van den Boom D., Meyer J., Hubner K., Bernemann C., Ortmeier C., Zenke M., Fleischmann B.K., Zaehres H., Scholer H.R. Oct4-Induced Pluripotency in Adult Neural Stem Cells \/\/ Cell. 2009. V. 136. P. 411-419.<br \/>\n<strong>\u0410\u043d\u043d\u043e\u0442\u0430\u0446\u0438\u044f<\/strong><br \/>\n\u0421\u0432\u0435\u0440\u0445\u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u044f \u0447\u0435\u0442\u044b\u0440\u0435\u0445 \u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432: OCT4, SOX2, KLF4 \u0438 C-MYC \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u0430 \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u043f\u043b\u044e\u0440\u0438\u043f\u043e\u0442\u0435\u043d\u0442\u043d\u043e\u0441\u0442\u044c \u0444\u0438\u0431\u0440\u043e\u0431\u043b\u0430\u0441\u0442\u043e\u0432 \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430 \u0438 \u043c\u044b\u0448\u0438. \u0412 \u0440\u0430\u0431\u043e\u0442\u0435 \u00abOct4-Induced Pluripotency in Adult Neural Stem Cells\u00bb \u0430\u0432\u0442\u043e\u0440\u044b \u043f\u043e\u043f\u044b\u0442\u0430\u043b\u0438\u0441\u044c \u0440\u0435\u043f\u0440\u043e\u0433\u0440\u0430\u043c\u043c\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u043d\u0435\u0439\u0440\u0430\u043b\u044c\u043d\u044b\u0435 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 (\u041d\u0421\u041a). \u041d\u0435\u0439\u0440\u0430\u043b\u044c\u043d\u044b\u0435 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 \u044d\u043d\u0434\u043e\u0433\u0435\u043d\u043d\u043e \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0442 \u0440\u044f\u0434 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u044b\u0445 \u0434\u043b\u044f \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u044f \u043f\u043b\u044e\u0440\u0438\u043f\u043e\u0442\u0435\u043d\u0442\u043d\u043e\u0441\u0442\u0438, \u0442\u0430\u043a\u0438\u0445 \u043a\u0430\u043a SOX2, KLF4 \u0438 C-MYC. \u0412 \u0440\u0430\u0431\u043e\u0442\u0435 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u043e, \u0447\u0442\u043e \u0441\u0432\u0435\u0440\u0445\u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u044f \u043e\u0434\u043d\u043e\u0433\u043e \u0444\u0430\u043a\u0442\u043e\u0440\u0430, OCT4, \u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u0430 \u0434\u043b\u044f \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u044f \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u043f\u043b\u044e\u0440\u0438\u043f\u043e\u0442\u0435\u043d\u0442\u043d\u044b\u0445 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a (\u0418\u041f\u0421\u041a) \u0438\u0437 \u041d\u0421\u041a. \u041f\u043e\u043b\u0443\u0447\u0435\u043d\u043d\u044b\u0435 \u043b\u0438\u043d\u0438\u0438 \u0418\u041f\u0421\u041a (1F iPS) \u043f\u0440\u043e\u044f\u0432\u043b\u044f\u043b\u0438 \u0441\u0432\u043e\u0439\u0441\u0442\u0432\u0430, \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u044b\u0435 \u0434\u043b\u044f \u044d\u043c\u0431\u0440\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0445 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a \u043a\u0430\u043a in vitro, \u0442\u0430\u043a \u0438 in vivo. \u041a\u043b\u0435\u0442\u043a\u0438 \u043b\u0438\u043d\u0438\u0439 1F iPS \u0443\u0434\u0430\u043b\u043e\u0441\u044c \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e \u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u0432 \u041d\u0421\u041a, \u043a\u0430\u0440\u0434\u0438\u043e\u043c\u0438\u043e\u0446\u0438\u0442\u044b \u0438 \u0433\u0435\u0440\u043c\u0438\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 in vitro. \u041a\u0440\u043e\u043c\u0435 \u0442\u043e\u0433\u043e, \u0434\u0430\u043d\u043d\u044b\u0435 \u043a\u043b\u0435\u0442\u043a\u0438 \u0443\u0441\u043f\u0435\u0448\u043d\u043e \u0444\u043e\u0440\u043c\u0438\u0440\u043e\u0432\u0430\u043b\u0438 \u0442\u0435\u0440\u0430\u0442\u043e\u043c\u044b \u0438 \u0443\u0447\u0430\u0441\u0442\u0432\u043e\u0432\u0430\u043b\u0438 \u0432 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0438 \u0445\u0438\u043c\u0435\u0440\u043d\u044b\u0445 \u0436\u0438\u0432\u043e\u0442\u043d\u044b\u0445 in vivo.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u041c\u0435\u0434\u0432\u0435\u0434\u0435\u0432 \u0421.\u041f. \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u0438\u0442 \u0434\u043e\u043a\u043b\u0430\u0434 \u00ab\u041f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u0435 \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u043f\u043b\u044e\u0440\u0438\u043f\u043e\u0442\u0435\u043d\u0442\u043d\u044b\u0445 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a \u0438\u0437 \u043d\u0435\u0439\u0440\u0430\u043b\u044c\u043d\u044b\u0445 \u0441\u0442\u0432\u043e\u043b\u043e\u0432\u044b\u0445 \u043a\u043b\u0435\u0442\u043e\u043a \u043c\u044b\u0448\u0438\u00bb. \u0414\u043e\u043a\u043b\u0430\u0434 \u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043b\u0435\u043d \u043f\u043e \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u0430\u043c \u0441\u0442\u0430\u0442\u044c\u0438: Kim J.B., Sebastiano V., Wu G., Arauzo-Bravo M.J., Sasse P., Gentile L., Ko K., Ruau D., Ehrich M., van den Boom D., Meyer J., Hubner K., Bernemann C., Ortmeier C., Zenke M., Fleischmann B.K., Zaehres H., [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/sites.icgbio.ru\/epigenetics\/wp-json\/wp\/v2\/posts\/606"}],"collection":[{"href":"https:\/\/sites.icgbio.ru\/epigenetics\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.icgbio.ru\/epigenetics\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/epigenetics\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/epigenetics\/wp-json\/wp\/v2\/comments?post=606"}],"version-history":[{"count":0,"href":"https:\/\/sites.icgbio.ru\/epigenetics\/wp-json\/wp\/v2\/posts\/606\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.icgbio.ru\/epigenetics\/wp-json\/wp\/v2\/media?parent=606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.icgbio.ru\/epigenetics\/wp-json\/wp\/v2\/categories?post=606"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.icgbio.ru\/epigenetics\/wp-json\/wp\/v2\/tags?post=606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}