{"id":35,"date":"2013-12-16T23:42:10","date_gmt":"2013-12-16T17:42:10","guid":{"rendered":"http:\/\/icg.nsc.ru\/isiah\/?page_id=35"},"modified":"2019-08-21T10:08:29","modified_gmt":"2019-08-21T07:08:29","slug":"%d0%be%d1%81%d0%be%d0%b1%d0%b5%d0%bd%d0%bd%d0%be%d1%81%d1%82%d0%b8-%d0%b3%d0%b8%d0%bf%d0%b5%d1%80%d1%82%d0%b5%d0%bd%d0%b7%d0%b8%d0%b2%d0%bd%d0%be%d0%b9-%d0%bb%d0%b8%d0%bd%d0%b8%d0%b8-%d0%ba%d1%80","status":"publish","type":"page","link":"https:\/\/sites.icgbio.ru\/isiah\/en\/","title":{"rendered":"ISIAH rats"},"content":{"rendered":"

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\"\u043a\u0440\u044b\u0441\u0430\"<\/a>The ISIAH (Inherited Stress-Induced Arterial <\/span>Hypertension) rat strain was developed to study the mechanisms of the stress-induced hypertension and its complications. The ISIAH<\/span> rats were selected from an outbred Wistar population for a systolic arterial blood pressure (SABP) increase <\/span>induced by 30 min restraint stress <\/span>in a small cylindrical wire mesh cage. <\/span>M<\/span>ore than 30 generations of close inbreeding by brother-sister matings resulted in a<\/span> high genetic homoge<\/span>neity of the ISIAH strain {Adarichev, 1996 #98}. The ISIAH rats have elevated <\/span>SABP<\/span> at basal condition (175.0 \u00b1 3.5 mmHg in males and 165.0 \u00b1 3.0 mmHg in females) and exhibit a dramatic increase in <\/span>SABP<\/span> when restrained {Markel, 1992 #3}<\/span>. <\/span>The ISIAH rats also show a number of other characteristic features of hypertensive state: hypertrophy of the left ventricle, increase in the wall thickness of the small arteries, and changes in the ECG <\/span>\"\u0441\u0442\u0440\u0435\u0441\u0441\"<\/a>pattern <\/span>{Markel, 1999 #21}. <\/span>ISIAH rats are characterized by increased kidney mass <\/span>{Redina, 2006 #4} and <\/span>some alterations in kidney histology <\/span>{Shmerling, 2001 #56}{Yakobson, 2007 #113}. <\/span>These<\/span> features<\/span>, the<\/span> genetically determined enhanced responsiveness to stressful stimulation, and the predominant involvement of the neuroendocrine hypothalamic\u2013pituitary\u2013adrenocortical and sympathetic adrenal medullary systems during the disease development let to consider the ISIAH rat strain as an advantageous model of the human hypertensive disease {Markel, 2007 #1}.<\/span><\/p>\n

\"\u043a\u0440\u044b\u0441\u0430\"<\/a>The ISIAH (Inherited Stress-Induced Arterial <\/span>Hypertension) rat strain was developed to study the mechanisms of the stress-induced hypertension and its complications. The ISIAH<\/span> rats were selected from an outbred Wistar population for a systolic arterial blood pressure (SABP) increase <\/span>induced by 30 min restraint stress <\/span>in a small cylindrical wire mesh cage. <\/span>M<\/span>ore than 30 generations of close inbreeding by brother-sister matings resulted in a<\/span> high genetic homoge<\/span>neity of the ISIAH strain {Adarichev, 1996 #98}. The ISIAH rats have elevated <\/span>SABP<\/span> at basal condition (175.0 \u00b1 3.5 mmHg in males and 165.0 \u00b1 3.0 mmHg in females) and exhibit a dramatic increase in <\/span>SABP<\/span> when restrained {Markel, 1992 #3}<\/span>. <\/span>The ISIAH rats also show a number of other characteristic features of hypertensive state: hypertrophy of the left ventricle, increase in the wall thickness of the small arteries, and changes in the ECG <\/span>\"\u0441\u0442\u0440\u0435\u0441\u0441\"<\/a>pattern <\/span>{Markel, 1999 #21}. <\/span>ISIAH rats are characterized by increased kidney mass <\/span>{Redina, 2006 #4} and <\/span>some alterations in kidney histology <\/span>{Shmerling, 2001 #56}{Yakobson, 2007 #113}. <\/span>These<\/span> features<\/span>, the<\/span> genetically determined enhanced responsiveness to stressful stimulation, and the predominant involvement of the neuroendocrine hypothalamic\u2013pituitary\u2013adrenocortical and sympathetic adrenal medullary systems during the disease development let to consider the ISIAH rat strain as an advantageous model of the human hypertensive disease {Markel, 2007 #1}.<\/span><\/p>\n

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The ISIAH (Inherited Stress-Induced Arterial Hypertension) rat strain was developed to study the mechanisms of the stress-induced hypertension and its complications. The ISIAH rats were selected from an outbred Wistar population for a systolic arterial blood pressure (SABP) increase induced … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.icgbio.ru\/isiah\/en\/wp-json\/wp\/v2\/pages\/35"}],"collection":[{"href":"https:\/\/sites.icgbio.ru\/isiah\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.icgbio.ru\/isiah\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/isiah\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/isiah\/en\/wp-json\/wp\/v2\/comments?post=35"}],"version-history":[{"count":2,"href":"https:\/\/sites.icgbio.ru\/isiah\/en\/wp-json\/wp\/v2\/pages\/35\/revisions"}],"predecessor-version":[{"id":398,"href":"https:\/\/sites.icgbio.ru\/isiah\/en\/wp-json\/wp\/v2\/pages\/35\/revisions\/398"}],"wp:attachment":[{"href":"https:\/\/sites.icgbio.ru\/isiah\/en\/wp-json\/wp\/v2\/media?parent=35"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}