Category Archives: Tom 19-4
Proton magnetic resonance spectroscopy of neurometabolites in the hippocampi of aggressive and tame male rats. R. G. Gulevich, A. E. Akulov, S. G. Shikhevich, R. V. Kozhemyakina, I. Z. Plyusnina
Abstract: Proportions of major neurometabolites with regard to their total amount in the dorsal region of the hippocampus were studied in adult male rats of populations selected for long for increase and absence of aggressivefearful response to humans and in …
Brain metabolites in ISIAH and Wistar rats. O. B. Shevelev, A. A. Seryapina, A. L. Markel, M. P. Moshkin
Abstract: Hypertension is one of the most common human diseases. This disease leads to serious disturbances such as myocardial infarction and stroke. Due to the development of nuclear magnetic resonance spectroscopy (NMRS), a decrease in neuron viability in different parts …
Study of the neuronal response to olfactory stimuli in control and LPS-stimulated mice by functional magnetic resonance imaging. A. E. Akulov, A. V. Romashchenko, O. B. Shevelev, D. V. Petrovski, A. A. Savelov, M. P. Moshkin
Abstract: Olfactory perception plays the key role in the interaction of animals with biotic factors of the species-specific econiche. Identification of odorants informs nocturnal animals about social environment, presence of predators, or infected food. Olfactory efficiency depends on physiological conditions; …
Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation. M. A. Tikhonova, T. G. Amstislavskaya
Abstract: Sexual behavior is one of the biologically highly relevant types of behavior. Sexual arousal, or an initial stage of sexual behavior, is of particular interest since it triggers all the following events but still remains the least known element …
Role of the Mucin-2 and Kaiso genes in the social behavior of mice. E. N. Kozhevnikova, K. M. Achasova, V. S. Korostina, E. B. Prokhortchouk, E. A. Litvinova
Abstract: Inflammatory processes in the gut lead to abnormalities in various systems of the body, in particular, to changes in the activity of the central nervous system. Although the mechanisms of these effects are not yet known, it has been …
Reproductive effects of the tumor necrosis factor (TNF) deficiency in mice. S. O. Maslennikova, G. V. Kontsevaya, M. A. Zolotykh, M. V. Anisimova, N. A. Feofanova, M. P. Moshkin, S. A. Nedospasov, L. A. Gerlinskaya
Abstract: TNF is a multifunctional cytokine that, at physiological concentrations, maintains the balance between apoptosis and survival of male germ cells and, at higher concentrations, has adverse effects on various stages of the reproductive process. Although ant-cytokine therapies have been …
Behavioral phenotyping of Kaiso-deficient mice. V. S. Korostina, A. V. Kulikov
Abstract: Kaiso is a methyl DNA-binding protein, which participates in the epigenetic regulation of gene expression. It binds methylated DNA with its zinc-finger domain and recruits repressive protein complexes to the methylated DNA fragments by the interaction of the BTB/POZ …
Behavioral phenotyping of mice deficient for tumor necrosis factor. D. V. Fursenko, N. V. Khotskin, V. A. Kulikov, A. V. Kulikov
Abstract: The tumor necrosis factor (TNF) is a cytokine exerting both homeostatic and pathophysiological roles in the central nervous system (CNS). It has been demonstrated that TNF plays roles in such diseases as Alzheimer’s disease, Parkinson’s disease and multiple sclerosis. …
Conducting and automating the water Morris maze test in SPF conditions. N. V. Khotskin, V. A. Kulikov, E. L. Zavyalov, D. V. Fursenko, A. V. Kulikov
Abstract: The water Morris maze is the basic test to study the spatial ability to learn as well as spatial memory in laboratory rodents. It is a part of a series of tests necessary for behavioral phenotyping of mutant and …
Effects of reproductive technologies and SPF status on some physiological and behavioral characteristics in rats with arterial hypertension (ISIAH strain). D. S. Ragaeva, T. O. Abramova, I. N. Rozhkova, E. Yu. Brusentsev, E. V. Kalinichenko, T. N. Igonina, S. Ya. Amstislavsky
Abstract: Modern standards of Laboratory Animal Science include working with laboratory animals of high quality, in particular, with specific pathogen free (SPF) mice and rats. On the other hand, assisted reproductive technologies (ART) are widely used in modern medicine for human …
