{"id":134,"date":"2020-08-09T02:37:54","date_gmt":"2020-08-09T05:37:54","guid":{"rendered":"http:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/?p=134"},"modified":"2020-11-06T15:19:54","modified_gmt":"2020-11-06T18:19:54","slug":"dopaminergic-neurons","status":"publish","type":"post","link":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/dopaminergic-neurons\/","title":{"rendered":"Dopaminergic neurons"},"content":{"rendered":"<p align=\"justify\"><a href=\"http:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Dopaminergic_neurons.jpg\"><img loading=\"lazy\" class=\"alignnone wp-image-599 size-full\" src=\"http:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Dopaminergic_neurons.jpg\" alt=\"\" width=\"1280\" height=\"1024\" srcset=\"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Dopaminergic_neurons.jpg 1280w, https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Dopaminergic_neurons-300x240.jpg 300w, https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Dopaminergic_neurons-700x560.jpg 700w, https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Dopaminergic_neurons-768x614.jpg 768w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/><\/a><\/p>\n<p align=\"justify\">The study of neurodegenerative diseases such as Parkinson\u2019s disease has long been hampered by the lack of models that accurately reproduce human brain cells in vitro. iPSC-differentiated dopaminergic neurons carry the same genetic signature as the donor and allow researchers to interrogate the causes of Parkinson\u2019s disease. We use several protocols to differentiate human iPSCs into midbrain-patterned neural progenitor cells (NPCs), astrocytes, and dopaminergic neurons (de Rus Jacquet, 2019; Niclis, J.C., 2016; Samata, B., 2015).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The study of neurodegenerative diseases such as Parkinson\u2019s disease has long been hampered by the lack of models that accurately reproduce human brain cells in vitro. iPSC-differentiated dopaminergic neurons carry the same genetic signature as the donor and allow researchers to interrogate the causes of Parkinson\u2019s disease. We use several protocols to differentiate human iPSCs [&hellip;]<\/p>\n","protected":false},"author":31,"featured_media":599,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[43,23],"tags":[33,36,35],"_links":{"self":[{"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/posts\/134"}],"collection":[{"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/comments?post=134"}],"version-history":[{"count":12,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/posts\/134\/revisions"}],"predecessor-version":[{"id":601,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/posts\/134\/revisions\/601"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/media\/599"}],"wp:attachment":[{"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/media?parent=134"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/categories?post=134"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/tags?post=134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}