{"id":143,"date":"2020-08-09T02:36:09","date_gmt":"2020-08-09T05:36:09","guid":{"rendered":"http:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/?p=143"},"modified":"2020-11-06T15:20:55","modified_gmt":"2020-11-06T18:20:55","slug":"medium-spiny-neurons","status":"publish","type":"post","link":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/medium-spiny-neurons\/","title":{"rendered":"Medium spiny neurons"},"content":{"rendered":"<p align=\"justify\"><a href=\"http:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Medium-spiny-neurons.jpg\"><img loading=\"lazy\" class=\"alignnone size-full wp-image-598\" src=\"http:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Medium-spiny-neurons.jpg\" alt=\"\" width=\"1280\" height=\"1024\" srcset=\"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Medium-spiny-neurons.jpg 1280w, https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Medium-spiny-neurons-300x240.jpg 300w, https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Medium-spiny-neurons-700x560.jpg 700w, https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-content\/uploads\/sites\/31\/2020\/09\/Differentiation-Medium-spiny-neurons-768x614.jpg 768w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/><\/a><\/p>\n<p align=\"justify\">iPSC-derived medium spiny neurons (MSNs) is a cellular model to study neurodegeneration in Huntington\u2019s disease. This model allows to study molecular mechanisms of the disease, large-scale drug screening, and toxicological studies. We generate MSNs from human PSCs using the protocol we created (Grigor\u2019eva et al., 2020, doi: 10.1007\/s10616-020-00406-7). The first stage involved dual-SMAD signalling inhibition through treatment with SB431542 and LDN193189 resulting in the generation of SOX1-, PAX6-, and OTX2-positive neuroectodermal cells. The next stage was the derivation of actively proliferating MSN progenitor cells. At the terminal stage MSNs expressed specific markers such as GABA and DARPP32.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>iPSC-derived medium spiny neurons (MSNs) is a cellular model to study neurodegeneration in Huntington\u2019s disease. This model allows to study molecular mechanisms of the disease, large-scale drug screening, and toxicological studies. We generate MSNs from human PSCs using the protocol we created (Grigor\u2019eva et al., 2020, doi: 10.1007\/s10616-020-00406-7). The first stage involved dual-SMAD signalling inhibition [&hellip;]<\/p>\n","protected":false},"author":31,"featured_media":598,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[43,23],"tags":[33,39,35],"_links":{"self":[{"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/posts\/143"}],"collection":[{"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/comments?post=143"}],"version-history":[{"count":11,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/posts\/143\/revisions"}],"predecessor-version":[{"id":602,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/posts\/143\/revisions\/602"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/media\/598"}],"wp:attachment":[{"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/media?parent=143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/categories?post=143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.icgbio.ru\/zakianlab-ipsccollection\/wp-json\/wp\/v2\/tags?post=143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}