Genes encoding mRNAs (or proteins) that were up- or down-regulated in response to TBEV infection — TBEVHostDB: a catalog of human genes involved in response to tick-borne encephalitis virus infection

All genes were collected from the research papers.
If the publication described a non-human mammalian gene/protein, the homologous human gene was found and included into the catalog.

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
A2M	alpha-2-macroglobulin	2		[Merzeniuk ZA et al., 2000]	10925884	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, liquor from patients with the meningeal and focal forms of tick-borne encephalitis [Merzeniuk ZA et al., 2000]
ATF6	activating transcription factor 6	22926		[Yu C. et al., 2013]	24177270	TBEV (strain K23)	TBEV	African Green Monkey	protein (cleaved form)	Expression was upregulated	in vitro, Vero E6 (Monkey African Green kidney A subclone of Vero76) cells, A552 [Yu C. et al., 2013]
BCL2	BCL2, apoptosis regulator	596		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, human NK cells in response to TBEV infection [Blom K et al., 2016]
BCL2	BCL2, apoptosis regulator	596		[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]
CCL2	C-C motif chemokine ligand 2	6347	MCP-1/CCL2, monocyte chemoattractant protein	[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
CCL2	C-C motif chemokine ligand 2	6347	MCP-1/CCL2, monocyte chemoattractant protein	[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CCL3	C-C motif chemokine ligand 3	6348	MIP-1α, MIP-1a, macrophage inflammatory protein 1α	[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
CCL3	C-C motif chemokine ligand 3	6348	MIP-1α, MIP-1a, macrophage inflammatory protein 1α	[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CCL4	C-C motif chemokine ligand 4	6351	MIP-1b/CCL-4, MIP-1beta, MIP-1b	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
				[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CCL5	C-C motif chemokine ligand 5	6352	RANTES	[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Zhang X et al., 2016]	27576490	TBEV, Far Eastern strain	TBEV	Mouse, Human	mRNA	Expression was upregulated	in vivo: mouse, in vitro: human brain-derived cell lines and primary progenitor-derived astrocytes [Zhang X et al., 2016]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CD27	CD27 molecule	939		[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]
CD3E	CD3e molecule	916	CD3	[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CD4	CD4 molecule	920		[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CD4	CD4 molecule	920		[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CD40	CD40 molecule	958		[Zajkowska JM al., 2006]	16463218	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF [Zajkowska JM al., 2006]
CD40LG	CD40 ligand	959	CD40L	[Zajkowska JM al., 2006]	16463218	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, serum [Zajkowska JM al., 2005]
CD40LG	CD40 ligand	959	CD40L	[Zajkowska JM al., 2006]	16463218	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF [Zajkowska JM al., 2006]
CD69	CD69 molecule	969		[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, monocytes, NK cells [Krylova NV et al., 2015]
				[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, CD8 T-lymphocytes [Krylova NV et al., 2015]
				[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, monocytes, granulocytes [Krylova NV et al., 2015]
				[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, NK cells, CD8 + Tlymphocytes, and CD4 + T-lymphocytes [Krylova NV et al., 2015]
				[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CD8A	CD8a molecule	925	CD8	[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CD8A	CD8a molecule	925	CD8	[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CXCL10	C-X-C motif chemokine ligand 10	3627	IP-10/CXCL10, IP-10, interferon γ-induced protein 10, IFN-γ-induced protein 10	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
				[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Zajkowska J et al., 2011]	22008312	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, serum, CSF [Zajkowska J et al., 2011]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CXCL11	C-X-C motif chemokine ligand 11	6373	I-TAC	[Zajkowska J et al., 2011]	22008312	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF [Zajkowska J et al., 2011]
CXCL12	C-X-C motif chemokine ligand 12	6387	SDF-1α	[Zajkowska J et al., 2011]	22008312	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF [Zajkowska J et al., 2011]
CXCL13	C-X-C motif chemokine ligand 13	10563	BLC/BCA-1	[Zajkowska J et al., 2011]	22008312	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, serum, CSF [Zajkowska J et al., 2011]
CXCL8	C-X-C motif chemokine ligand 8	3576	IL-8	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
CXCL8	C-X-C motif chemokine ligand 8	3576	IL-8	[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, plasma [Blom K et al., 2016]
DDX58	DExD/H-box helicase 58	23586	RIG-I	[Zhang X et al., 2016]	27576490	TBEV, Far Eastern strain	TBEV	Human	protein	Expression was upregulated	in vitro: Human T98G cells [Zhang X et al., 2016]
EOMES	eomesodermin	8320		[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]
FAS	Fas cell surface death receptor	355	CD95	[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, NK cells [Krylova NV et al., 2015]
FAS	Fas cell surface death receptor	355	CD95	[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, NK cells [Krylova NV et al., 2015]
FASLG	Fas ligand	356	FasL	[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
G3BP1	G3BP stress granule assembly factor 1	10146		[Albornoz A et al., 2014]	24696465	TBEV strain Neudoerfl	TBEV	Human	protein	Expression was upregulated	in vitro, human U2OS cells [Albornoz A et al., 2014]
GFAP	glial fibrillary acidic protein	2670		[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
GSN	gelsolin	2934		[Kułakowska A et al., 2011]	21389683	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, blood [Kułakowska A et al., 2011]
GZMB	granzyme B	3002	Gzm B	[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, human NK cells in response to TBEV infection [Blom K et al., 2016]
				[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was upregulated	In vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]
				[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
GZMM	granzyme M	3004	Gzm A	[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
HMOX1	heme oxygenase 1	3162		[Kuzmenko YV et al., 2016a]	27875810	TBEV	NS1	Human	mRNA	Expression was upregulated	in vitro, HEK 293T cells (Human Embryonic Kidney 293 transformed with large T antigen), RT-qPCR [Kuzmenko YV et al., 2016a]
HSPA1A	heat shock protein family A (Hsp70) member 1A	3303	Hsp72	[Yu C. et al., 2013]	24177270	TBEV (strain K23)	TBEV	African Green Monkey	protein	Expression was upregulated	in vitro, Vero E6 (Monkey African Green kidney A subclone of Vero76) cells, A549 [Yu C. et al., 2013]
ICAM1	intercellular adhesion molecule 1	3383	CD54	[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, monocytes [Krylova NV et al., 2015]
				[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, monocytes, granulocytes [Krylova NV et al., 2015]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
				[Moniuszko A et al., 2012]	22705151	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) [Moniuszko A et al., 2012]
				[Pietruczuk M et al., 2006]	16909787	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) and serum [Pietruczuk M et al., 2006]
				[Zajkowska JM al., 2005]	16245421	TBEV	TBEV	Human	protein in stress granules	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) [Zajkowska JM al., 2005]
ICAM2	intercellular adhesion molecule 2	3384		[Zajkowska JM al., 2005]	16245421	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, serum [Zajkowska JM al., 2005]
ICAM2	intercellular adhesion molecule 2	3384		[Pietruczuk M et al., 2006]	16909787	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) [Pietruczuk M et al., 2006]
ICAM3	intercellular adhesion molecule 3	3385		[Zajkowska JM al., 2005]	16245421	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) [Zajkowska JM al., 2005]
ICAM3	intercellular adhesion molecule 3	3385		[Pietruczuk M et al., 2006]	16909787	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) and serum [Pietruczuk M et al., 2006]
IFIH1	interferon induced with helicase C domain 1	64135	MDA5	[Zhang X et al., 2016]	27576490	TBEV, Far Eastern strain	TBEV	Human	protein	Expression was upregulated	in vitro: Human T98G cells [Zhang X et al., 2016]
IFIT1	interferon induced protein with tetratricopeptide repeats 1	3434	IFI-56K	[Gavrilov BG et al., 2003]	12708317	TBEV (strain 205)	TBEV	Human	mRNA	Expression was upregulated	in vitro, Human embryonic kidney cell line RH Infected with Tick-borne Encephalitis Virus [Gavrilov BG et al., 2003]
IFIT2	interferon induced protein with tetratricopeptide repeats 2	3433	IFI-54k	[Gavrilov BG et al., 2003]	12708317	TBEV (strain 205)	TBEV	Human	mRNA	Expression was upregulated	in vitro, Human embryonic kidney cell line RH Infected with Tick-borne Encephalitis Virus [Gavrilov BG et al., 2003]
IFNA1	interferon alpha 1	3439	IFN-a, interferon alpha	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
IFNA1	interferon alpha 1	3439	IFN-a, interferon alpha	[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]
IFNA2	interferon alpha 2	3440		[Lindqvist R et al., 2016]	27776548	TBEV	TBEV	Mouse	mRNA	Expression was upregulated	in vitro, Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]
IFNAR1	interferon alpha and beta receptor subunit 1	3454		[Lubick KJ et al., 2015]	26159719	TBEV (Sofjin strain)	TBEV	Human	protein	Expression was downregulated	in vitro, HEK293 (Human Embryonic Kidney) cells [Lubick KJ et al., 2015]
IFNB1	interferon beta 1	3456		[Lindqvist R et al., 2016]	27776548	TBEV	TBEV	Mouse	mRNA	Expression was upregulated	in vitro, Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]
IFNB1	interferon beta 1	3456		[Grygorczuk S et al., 2015]	25461390	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF and serum [Grygorczuk S et al., 2015]
IFNG	interferon gamma	3458	IFN-γ	[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, plasma [Blom K et al., 2016]
				[Aberle JH et al., 2015]	26465323	TBEV	TBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)	Human	protein	Expression was upregulated	in vivo, TBEV-specific polyfunctional human CD4+ T cells (L-2+IFN-γ+) [Aberle JH et al., 2015]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
				[Gomez I et al., 2003]	14583154	TBEV (vaccine against TBE)	E protein (trancated)	Human	protein	Expression was upregulated	in vivo, CD4+ T lymphocytes specific for E protein from healthy blood donors vaccinated against TBEV with FSME®-IMMUN Inject (Baxter IMMUNO, Austria) [Gomez I et al., 2003]
IFNL3	interferon lambda 3	282617	IL28B	[Grygorczuk S et al., 2015]	25461391	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF [Grygorczuk S et al., 2015]
IKZF2	IKAROS family zinc finger 2	22807	Helios	[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was downregulated	In vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]
IL10	interleukin 10	3586		[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
IL10	interleukin 10	3586		[Grygorczuk S et al., 2015]	25461389	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF and serum [Grygorczuk S et al., 2015]
IL12A	interleukin 12A	3592		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]
IL12B	interleukin 12B	3593		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]
IL15	interleukin 15	3600		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]
IL18	interleukin 18	3606		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]
IL1A	interleukin 1 alpha	3552		[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
IL1B	interleukin 1 beta	3553		[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
IL1B	interleukin 1 beta	3553		[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
IL2	interleukin 2	3558		[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]
				[Aberle JH et al., 2015]	26465323	TBEV	TBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)	Human	protein	Expression was downregulated	in vivo, TBEV-specific polyfunctional human CD4+ T cells [Aberle JH et al., 2015]
IL2RA	interleukin 2 receptor subunit alpha	3559	CD25	[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, NK cells [Krylova NV et al., 2015]
				[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, CD8 T-lymphocytes [Krylova NV et al., 2015]
				[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
IL4	interleukin 4	3565		[Tun MM et al., 2014]	24938868	TBEV, Oshima strain, Sofjin strain	TBEV	Mouse	mRNA	Expression was downregulated	In vivo, spleen [Tun MM et al., 2014]
IL5	interleukin 5	3567		[Gomez I et al., 2003]	14583154	TBEV (vaccine against TBE)	E protein (trancated)	Human	protein	Expression was upregulated	in vivo, CD4+ T lymphocytes specific for E protein from healthy blood donors vaccinated against TBEV with FSME®-IMMUN Inject (Baxter IMMUNO, Austria) [Gomez I et al., 2003]
IL6	interleukin 6	3569		[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
				[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, plasma [Blom K et al., 2016]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
IL7R	interleukin 7 receptor	3575	CD127	[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]
IRF1	interferon regulatory factor 1	3659		[Robertson SJ et al., 2014]	24532583	TBEV (Sofjin strain)	TBEV	Mouse	protein	Expression was downregulated	in vitro, bone-marrow derived dendritic cells [Robertson SJ et al., 2014]
IRF3	interferon regulatory factor 3	3661		[Zhang X et al., 2016]	27576490	TBEV, Far Eastern strain	TBEV	Human	protein (phosphorylated)	Phosphorilation was upregulated	in vitro: Human T98G cells [Zhang X et al., 2016]
ITGAM	integrin subunit alpha M	3684	CD11b	[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, monocytes [Krylova NV et al., 2015]
ITGAM	integrin subunit alpha M	3684	CD11b	[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, monocytes, granulocytes, and NK cells [Krylova NV et al., 2015]
LILRA4	leukocyte immunoglobulin like receptor A4	23547	ILT7	[Dillmann C et al., 2016]	26783340	TBEV (FSME-IMMUN -inactivated whole virus vaccine against TBE)	FSME-IMMUN -inactivated whole virus vaccine against TBE	Human	protein (cell surface)	Expression was downregulated	in vitro, human plasmacytoid dendritic cells (pDCs) [Dillmann C et al., 2016]
LTF	lactotransferrin	4057		[Merzeniuk ZA et al., 2003]	12774664	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, liquor and blood of patients with tick-borne encephalitis [Merzeniuk ZA et al., 2000]
MKI67	marker of proliferation Ki-67	4288	Ki67	[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, human NK cells in response to TBEV infection [Blom K et al., 2016]
MMP9	matrix metallopeptidase 9	4318		[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
MMP9	matrix metallopeptidase 9	4318		[Palus M et al., 2014b]	25000960	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, serum [Palus M et al., 2014b]
NQO1	NAD(P)H quinone dehydrogenase 1	1728		[Kuzmenko YV et al., 2016a]	27875810	TBEV	NS1	Human	mRNA	Expression was upregulated	in vitro, HEK 293T cells (Human Embryonic Kidney 293 transformed with large T antigen), RT-qPCR [Kuzmenko YV et al., 2016a]
OAS1	2′-5′-oligoadenylate synthetase 1	4938		[Yoshii K et al., 2013]	23266832	TBEV (Sofjin-HO or Oshima 5-10 strain)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Yoshii K et al., 2013]
PDCD1	programmed cell death 1	5133	PD-1	[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]
PRF1	perforin 1	5551		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, human NK cells in response to TBEV infection [Blom K et al., 2016]
PRF1	perforin 1	5551		[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]
PRF1	perforin 1	5551		[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
PSMB10	proteasome subunit beta 10	5699		[Kuzmenko YV et al., 2016b]	27239857	TBEV (Western subtype)	NS1	Human	mRNA	Expression was upregulated	in vitro, HeLa [Kuzmenko YV et al., 2016b]
PSMB8	proteasome subunit beta 8	5696		[Kuzmenko YV et al., 2016b]	27239857	TBEV (Western subtype)	NS1	Human	mRNA	Expression was upregulated	in vitro, HeLa [Kuzmenko YV et al., 2016b]
RSAD2	radical S-adenosyl methionine domain containing 2	91543	Viperin	[Lindqvist R et al., 2016]	27776548	TBEV	TBEV	Mouse	mRNA	Expression was upregulated	in vitro, Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]
SOCS1	suppressor of cytokine signaling 1	8651		[Mansfield KL et al., 2010]	20854017	TBEV, strain Neudoerfl	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
SOCS3	suppressor of cytokine signaling 3	9021		[Mansfield KL et al., 2010]	20854017	TBEV, strain Neudoerfl	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
TBK1	TANK binding kinase 1	29110		[Zhang X et al., 2016]	27576490	TBEV, Far Eastern strain	TBEV	Human	protein (phosphorylated)	Phosphorilation was upregulated	in vitro: Human T98G cells [Zhang X et al., 2016]
TBX21	T-box 21	30009	Tbet, T-bet	[Aberle JH et al., 2015]	26465323	TBEV	TBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)	Human	protein	Expression was upregulated	in vivo, TBEV-specific polyfunctional human CD4+ T cells (L-2+IFN-γ+) [Aberle JH et al., 2015]
TBX21	T-box 21	30009	Tbet, T-bet	[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]
TNF	tumor necrosis factor	7124	tumour necrosis factor α	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
				[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, plasma [Blom K et al., 2016]
TNF	tumor necrosis factor	7124	TNFa	[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
XBP1	X-box binding protein 1	7494	sXBP1	[Yu C. et al., 2013]	24177270	TBEV (strain K23)	TBEV	African Green Monkey	mRNA, protein	Expression was upregulated	in vitro, Vero E6 (Monkey African Green kidney A subclone of Vero76) cells, A550 [Yu C. et al., 2013]