Genes encoding proteins that were required for inhibitory effect of other proteins against TBEV or attenuated its antiviral activity

EntrezGene
Official
Symbol		 Official Full Name EntrezGene
Gene ID		 Also
known as		 Other
essential
protein		 References PMID Type of
interaction		 Virus, strain Host organism In vivo/in vitro                                        
ARHGEF7 Rho guanine nucleotide exchange factor 7 8874 βPIX, BETA-PIX SCRIB [Wigerius M et al., 2010] 20363326 Physical  interactions with important protein TBEV Human in vitro, PC12 cells derived from a rat pheochromocytoma,  COS-7 (fibroblast-like cell lines derived from monkey kidney tissue)   [Wigerius M et al., 2010].
CIAO1 cytosolic iron-sulfur assembly component 1 9391 RSAD2 / Viperin [Upadhyay AS et al., 2014] 24245804 Physical  interactions with important protein TBEV Human in vitro, human HEK293 cells [Upadhyay AS et al., 2014]
ERN1 endoplasmic reticulum to nucleus signaling 1 2081 IRE1a XBP1 [Yu C. et al., 2013]  [Yoshida H et al., 2001] 24177270, 11779464 Physical  interactions with important protein TBEV Human, Monkey in vitro, Hela cells [Yoshida H et al., 2001] Monkey Vero E6 cells [Yu C. et al., 2013] .
PEPD peptidase D 5184 IFNAR1 [Lubick KJ et al., 2015] 26159719 Interaction within pathway TBEV (strain Sofjin) Human in vitro, HEK293 (Human Embryonic Kidney). In vivo, human fibroblasts
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 5879 SCRIB [Wigerius M et al., 2010] 20363326 Physical  interactions with important protein TBEV Human in vitro, PC12 cells derived from a rat pheochromocytoma,  COS-7 (fibroblast-like cell lines derived from monkey kidney tissue)   [Wigerius M et al., 2010].
S1PR4 sphingosine-1-phosphate receptor 4 8698 LILRA4 [Dillmann C et al., 2016] 26783340 Interaction within pathway TBEV (FSME-IMMUN -inactivated whole virus vaccine against TBE) Human in vitro, human plasmacytoid dendritic cells (pDCs)