All genes from the catalog (140 genes) — TBEVHostDB: a catalog of human genes involved in response to tick-borne encephalitis virus infection

EntrezGene
Official
Symbol

Official Full Name

EntrezGene
Gene ID

Physical
interaction

Up or
down
regulated

Allelic
variant

Increased/
attenuated
antiviral
activity

Knockout

A2M

alpha-2-macroglobulin

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
A2M	alpha-2-macroglobulin	2		[Merzeniuk ZA et al., 2000]	10925884	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, liquor from patients with the meningeal and focal forms of tick-borne encephalitis [Merzeniuk ZA et al., 2000]

ARHGAP25

Rho GTPase activating protein 25

9938

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
ARHGAP25	Rho GTPase activating protein 25	9938		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

ARHGEF7

Rho guanine nucleotide exchange factor 7

8874

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	Other essential protein	References	PMID	Type of interaction	Virus, strain	Host organism	In vivo/in vitro
ARHGEF7	Rho guanine nucleotide exchange factor 7	8874	βPIX, BETA-PIX	SCRIB	[Wigerius M et al., 2010]	20363326	Physical interactions with important protein	TBEV	Human	in vitro, PC12 cells derived from a rat pheochromocytoma, COS-7 (fibroblast-like cell lines derived from monkey kidney tissue) [Wigerius M et al., 2010].

ARID1B

AT-rich interaction domain 1B

57492

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	SNP ID	Reference	PMID	SNP location	Population	Phenotypic trait caused by allelic variants
ARID1B	AT-rich interaction domain 1B	57492		rs287886	[Grygorczuk S et al., 2015]	25461389	ARID1B, first intron	Polish population	IL-10 concentration in CSF in TBE patients [Grygorczuk S et al., 2015]

ARID2

AT-rich interaction domain 2

196528

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
ARID2	AT-rich interaction domain 2	196528		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

ARNTL

aryl hydrocarbon receptor nuclear translocator like

406

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
ARNTL	aryl hydrocarbon receptor nuclear translocator like	406		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

ATF6

activating transcription factor 6

22926

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
ATF6	activating transcription factor 6	22926		[Yu C. et al., 2013]	24177270	TBEV (strain K23)	TBEV	African Green Monkey	protein (cleaved form)	Expression was upregulated	in vitro, Vero E6 (Monkey African Green kidney A subclone of Vero76) cells, A552 [Yu C. et al., 2013]

BCL2

BCL2, apoptosis regulator

596

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
BCL2	BCL2, apoptosis regulator	596		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, human NK cells in response to TBEV infection [Blom K et al., 2016]
BCL2	BCL2, apoptosis regulator	596		[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]

BICD1

BICD cargo adaptor 1

636

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
BICD1	BICD cargo adaptor 1	636		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

CASK

calcium/calmodulin dependent serine protein kinase

8573

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
CASK	calcium/calmodulin dependent serine protein kinase	8573		[Melik W et al., 2012]	22796133	TBEV	Human	NS5 [Melik W et al., 2012]	in vitro, in vitro, PDZ array membranes [Melik W et al., 2012]

CCDC14

coiled-coil domain containing 14

64770

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
CCDC14	coiled-coil domain containing 14	64770		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

CCL2

C-C motif chemokine ligand 2

6347

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CCL2	C-C motif chemokine ligand 2	6347	MCP-1/CCL2, monocyte chemoattractant protein	[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
CCL2	C-C motif chemokine ligand 2	6347	MCP-1/CCL2, monocyte chemoattractant protein	[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

CCL3

C-C motif chemokine ligand 3

6348

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CCL3	C-C motif chemokine ligand 3	6348	MIP-1α, MIP-1a, macrophage inflammatory protein 1α	[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
CCL3	C-C motif chemokine ligand 3	6348	MIP-1α, MIP-1a, macrophage inflammatory protein 1α	[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

CCL4

C-C motif chemokine ligand 4

6351

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CCL4	C-C motif chemokine ligand 4	6351	MIP-1b/CCL-4, MIP-1beta, MIP-1b	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
				[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

CCL5

C-C motif chemokine ligand 5

6352

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CCL5	C-C motif chemokine ligand 5	6352	RANTES	[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Zhang X et al., 2016]	27576490	TBEV, Far Eastern strain	TBEV	Mouse, Human	mRNA	Expression was upregulated	in vivo: mouse, in vitro: human brain-derived cell lines and primary progenitor-derived astrocytes [Zhang X et al., 2016]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

CCR5

C-C motif chemokine receptor 5 (gene/pseudogene)

1234

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	SNP ID	Reference	PMID	SNP location	Population	Phenotypic trait caused by allelic variants
CCR5	C-C motif chemokine receptor 5 (gene/pseudogene)	1234		rs333 (CCR5D32)	[Mickienė A et al., 2014] [Kindberg E et al., 2008]	25226020, 18179389	CCR5, exon 1 or 2	Lithuanian Population	The prevalence of CCR5D32 homozygotes was higher in TBE patients than in controls (p,0.05) [Mickienė A et al., 2014]. CCR5 32 allele prevalence increased with the clinical severity of disease [Kindberg E et al., 2008]

CD209

CD209 molecule

30835

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	SNP ID	Reference	PMID	SNP location	Population	Phenotypic trait caused by allelic variants
CD209	CD209 molecule	30835		rs2287886	[Barkhash AV et al., 2012]	22061615	CD209, promoter region	Russian population	Predisposition to severe forms of TBE in the Russian population [Barkhash AV et al., 2012]

CD27

CD27 molecule

939

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CD27	CD27 molecule	939		[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]

CD3E

CD3e molecule

916

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CD3E	CD3e molecule	916	CD3	[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

CD4

CD4 molecule

920

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CD4	CD4 molecule	920		[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CD4	CD4 molecule	920		[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

CD40

CD40 molecule

958

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CD40	CD40 molecule	958		[Zajkowska JM al., 2006]	16463218	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF [Zajkowska JM al., 2006]

CD40LG

CD40 ligand

959

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CD40LG	CD40 ligand	959	CD40L	[Zajkowska JM al., 2006]	16463218	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, serum [Zajkowska JM al., 2005]
CD40LG	CD40 ligand	959	CD40L	[Zajkowska JM al., 2006]	16463218	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF [Zajkowska JM al., 2006]

CD69

CD69 molecule

969

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CD69	CD69 molecule	969	[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, monocytes, NK cells [Krylova NV et al., 2015]
			[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, CD8 T-lymphocytes [Krylova NV et al., 2015]
			[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, monocytes, granulocytes [Krylova NV et al., 2015]
			[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, NK cells, CD8 + Tlymphocytes, and CD4 + T-lymphocytes [Krylova NV et al., 2015]
			[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

CD8A

CD8a molecule

925

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CD8A	CD8a molecule	925	CD8	[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
CD8A	CD8a molecule	925	CD8	[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	In vivo/ in vitro	Host organism	Effect	Experiment
CD8A	CD8a molecule	925	CD8a	[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	in vivo	mouse	Slower development of the disease [Růžek D et al., 2011]	CD8a-/- mice were inoculated subcutaneously with TBEV (100 pfu) Sodium fluorescein (Sigma-Aldrich), was used to detect fluid shifts between the circulation and CNS, which occur when BBB permeability becomes enhanced [Růžek D et al., 2011]

CIAO1

cytosolic iron-sulfur assembly component 1

9391

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	Other essential protein	References	PMID	Type of interaction	Virus, strain	Host organism	In vivo/in vitro
CIAO1	cytosolic iron-sulfur assembly component 1	9391		RSAD2 / Viperin	[Upadhyay AS et al., 2014]	24245804	Physical interactions with important protein	TBEV	Human	in vitro, human HEK293 cells [Upadhyay AS et al., 2014]

CXCL10

C-X-C motif chemokine ligand 10

3627

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CXCL10	C-X-C motif chemokine ligand 10	3627	IP-10/CXCL10, IP-10, interferon γ-induced protein 10, IFN-γ-induced protein 10	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
				[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Zajkowska J et al., 2011]	22008312	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, serum, CSF [Zajkowska J et al., 2011]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

CXCL11

C-X-C motif chemokine ligand 11

6373

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CXCL11	C-X-C motif chemokine ligand 11	6373	I-TAC	[Zajkowska J et al., 2011]	22008312	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF [Zajkowska J et al., 2011]

CXCL12

C-X-C motif chemokine ligand 12

6387

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CXCL12	C-X-C motif chemokine ligand 12	6387	SDF-1α	[Zajkowska J et al., 2011]	22008312	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF [Zajkowska J et al., 2011]

CXCL13

C-X-C motif chemokine ligand 13

10563

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CXCL13	C-X-C motif chemokine ligand 13	10563	BLC/BCA-1	[Zajkowska J et al., 2011]	22008312	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, serum, CSF [Zajkowska J et al., 2011]

CXCL8

C-X-C motif chemokine ligand 8

3576

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
CXCL8	C-X-C motif chemokine ligand 8	3576	IL-8	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
CXCL8	C-X-C motif chemokine ligand 8	3576	IL-8	[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, plasma [Blom K et al., 2016]

DDX58

DExD/H-box helicase 58

23586

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
DDX58	DExD/H-box helicase 58	23586	RIG-I	[Zhang X et al., 2016]	27576490	TBEV, Far Eastern strain	TBEV	Human	protein	Expression was upregulated	in vitro: Human T98G cells [Zhang X et al., 2016]

DNTTIP2

deoxynucleotidyltransferase terminal interacting protein 2

30836

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
DNTTIP2	deoxynucleotidyltransferase terminal interacting protein 2	30836		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

EMILIN1

elastin microfibril interfacer 1

11117

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
EMILIN1	elastin microfibril interfacer 1	11117		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

ENO1

enolase 1

2023

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
ENO1	enolase 1	2023		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

EOMES

eomesodermin

8320

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
EOMES	eomesodermin	8320		[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]

ERN1

endoplasmic reticulum to nucleus signaling 1

2081

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	Other essential protein	References	PMID	Type of interaction	Virus, strain	Host organism	In vivo/in vitro
ERN1	endoplasmic reticulum to nucleus signaling 1	2081	IRE1a	XBP1	[Yu C. et al., 2013] [Yoshida H et al., 2001]	24177270, 11779464	Physical interactions with important protein	TBEV	Human, Monkey	in vitro, Hela cells [Yoshida H et al., 2001] Monkey Vero E6 cells [Yu C. et al., 2013] .

FAM184A

family with sequence similarity 184 member A

79632

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
FAM184A	family with sequence similarity 184 member A	79632		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

FAS

Fas cell surface death receptor

355

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
FAS	Fas cell surface death receptor	355	CD95	[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, NK cells [Krylova NV et al., 2015]
FAS	Fas cell surface death receptor	355	CD95	[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, NK cells [Krylova NV et al., 2015]

FASLG

Fas ligand

356

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
FASLG	Fas ligand	356	FasL	[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

FURIN

furin, paired basic amino acid cleaving enzyme

5045

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
FURIN	furin, paired basic amino acid cleaving enzyme	5045		[Stadler K et al., 1997]	9343204	TBEV	Bovine	prM [Stadler K et al., 1997]	in vitro, BHK-21 (Baby hamster kidney) cells [Stadler K et al., 1997]

G3BP1

G3BP stress granule assembly factor 1

10146

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
G3BP1	G3BP stress granule assembly factor 1	10146		[Albornoz A et al., 2014]	24696465	TBEV strain Neudoerfl	TBEV	Human	protein	Expression was upregulated	in vitro, human U2OS cells [Albornoz A et al., 2014]

GFAP

glial fibrillary acidic protein

2670

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
GFAP	glial fibrillary acidic protein	2670		[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]

GIPC1

GIPC PDZ domain containing family member 1

10755

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
GIPC1	GIPC PDZ domain containing family member 1	10755		[Melik W et al., 2012]	22796133	TBEV	Human	NS5 [Melik W et al., 2012]	in vitro, in vitro, PDZ array membranes [Melik W et al., 2012]

GOPC

golgi associated PDZ and coiled-coil motif containing

57120

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
GOPC	golgi associated PDZ and coiled-coil motif containing	57120		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

GRIP2

glutamate receptor interacting protein 2

80852

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
GRIP2	glutamate receptor interacting protein 2	80852		[Melik W et al., 2012]	22796133	TBEV	Human	NS5 [Melik W et al., 2012]	in vitro, in vitro, PDZ array membranes [Melik W et al., 2012]

GRN

granulin precursor

2896

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
GRN	granulin precursor	2896		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

GSN

gelsolin

2934

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
GSN	gelsolin	2934		[Kułakowska A et al., 2011]	21389683	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, blood [Kułakowska A et al., 2011]

GZMB

granzyme B

3002

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
GZMB	granzyme B	3002	Gzm B	[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, human NK cells in response to TBEV infection [Blom K et al., 2016]
				[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was upregulated	In vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]
				[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

GZMM

granzyme M

3004

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
GZMM	granzyme M	3004	Gzm A	[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

HMOX1

heme oxygenase 1

3162

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
HMOX1	heme oxygenase 1	3162		[Kuzmenko YV et al., 2016a]	27875810	TBEV	NS1	Human	mRNA	Expression was upregulated	in vitro, HEK 293T cells (Human Embryonic Kidney 293 transformed with large T antigen), RT-qPCR [Kuzmenko YV et al., 2016a]

HNRNPF

heterogeneous nuclear ribonucleoprotein F

3185

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
HNRNPF	heterogeneous nuclear ribonucleoprotein F	3185	HNRPF	[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

HSPA1A

heat shock protein family A (Hsp70) member 1A

3303

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
HSPA1A	heat shock protein family A (Hsp70) member 1A	3303	Hsp72	[Yu C. et al., 2013]	24177270	TBEV (strain K23)	TBEV	African Green Monkey	protein	Expression was upregulated	in vitro, Vero E6 (Monkey African Green kidney A subclone of Vero76) cells, A549 [Yu C. et al., 2013]

ICAM1

intercellular adhesion molecule 1

3383

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
ICAM1	intercellular adhesion molecule 1	3383	CD54	[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, monocytes [Krylova NV et al., 2015]
				[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, monocytes, granulocytes [Krylova NV et al., 2015]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
				[Moniuszko A et al., 2012]	22705151	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) [Moniuszko A et al., 2012]
				[Pietruczuk M et al., 2006]	16909787	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) and serum [Pietruczuk M et al., 2006]
				[Zajkowska JM al., 2005]	16245421	TBEV	TBEV	Human	protein in stress granules	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) [Zajkowska JM al., 2005]

ICAM2

intercellular adhesion molecule 2

3384

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
ICAM2	intercellular adhesion molecule 2	3384		[Zajkowska JM al., 2005]	16245421	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, serum [Zajkowska JM al., 2005]
ICAM2	intercellular adhesion molecule 2	3384		[Pietruczuk M et al., 2006]	16909787	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) [Pietruczuk M et al., 2006]

ICAM3

intercellular adhesion molecule 3

3385

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
ICAM3	intercellular adhesion molecule 3	3385		[Zajkowska JM al., 2005]	16245421	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) [Zajkowska JM al., 2005]
ICAM3	intercellular adhesion molecule 3	3385		[Pietruczuk M et al., 2006]	16909787	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, cerebrospinal fluid (CSF) and serum [Pietruczuk M et al., 2006]

IFIH1

interferon induced with helicase C domain 1

64135

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IFIH1	interferon induced with helicase C domain 1	64135	MDA5	[Zhang X et al., 2016]	27576490	TBEV, Far Eastern strain	TBEV	Human	protein	Expression was upregulated	in vitro: Human T98G cells [Zhang X et al., 2016]

IFIT1

interferon induced protein with tetratricopeptide repeats 1

3434

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IFIT1	interferon induced protein with tetratricopeptide repeats 1	3434	IFI-56K	[Gavrilov BG et al., 2003]	12708317	TBEV (strain 205)	TBEV	Human	mRNA	Expression was upregulated	in vitro, Human embryonic kidney cell line RH Infected with Tick-borne Encephalitis Virus [Gavrilov BG et al., 2003]

IFIT2

interferon induced protein with tetratricopeptide repeats 2

3433

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IFIT2	interferon induced protein with tetratricopeptide repeats 2	3433	IFI-54k	[Gavrilov BG et al., 2003]	12708317	TBEV (strain 205)	TBEV	Human	mRNA	Expression was upregulated	in vitro, Human embryonic kidney cell line RH Infected with Tick-borne Encephalitis Virus [Gavrilov BG et al., 2003]

IFNA1

interferon alpha 1

3439

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IFNA1	interferon alpha 1	3439	IFN-a, interferon alpha	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
IFNA1	interferon alpha 1	3439	IFN-a, interferon alpha	[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]

IFNA2

interferon alpha 2

3440

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IFNA2	interferon alpha 2	3440		[Lindqvist R et al., 2016]	27776548	TBEV	TBEV	Mouse	mRNA	Expression was upregulated	in vitro, Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]

IFNAR1

interferon alpha and beta receptor subunit 1

3454

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IFNAR1	interferon alpha and beta receptor subunit 1	3454		[Lubick KJ et al., 2015]	26159719	TBEV (Sofjin strain)	TBEV	Human	protein	Expression was downregulated	in vitro, HEK293 (Human Embryonic Kidney) cells [Lubick KJ et al., 2015]

IFNB1

interferon beta 1

3456

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IFNB1	interferon beta 1	3456		[Lindqvist R et al., 2016]	27776548	TBEV	TBEV	Mouse	mRNA	Expression was upregulated	in vitro, Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]
IFNB1	interferon beta 1	3456		[Grygorczuk S et al., 2015]	25461390	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF and serum [Grygorczuk S et al., 2015]

IFNG

interferon gamma

3458

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IFNG	interferon gamma	3458	IFN-γ	[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, plasma [Blom K et al., 2016]
				[Aberle JH et al., 2015]	26465323	TBEV	TBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)	Human	protein	Expression was upregulated	in vivo, TBEV-specific polyfunctional human CD4+ T cells (L-2+IFN-γ+) [Aberle JH et al., 2015]
				[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]
				[Gomez I et al., 2003]	14583154	TBEV (vaccine against TBE)	E protein (trancated)	Human	protein	Expression was upregulated	in vivo, CD4+ T lymphocytes specific for E protein from healthy blood donors vaccinated against TBEV with FSME®-IMMUN Inject (Baxter IMMUNO, Austria) [Gomez I et al., 2003]

IFNL3

interferon lambda 3

282617

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IFNL3	interferon lambda 3	282617	IL28B	[Grygorczuk S et al., 2015]	25461391	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF [Grygorczuk S et al., 2015]

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	SNP ID	Reference	PMID	SNP location	Population	Phenotypic trait caused by allelic variants
IFNL3	interferon lambda 3	282617	IL28B	rs8103142	[Barkhash AV et al. 2016]	27068548	IFNL3, exon 2, Lys70Arg or exon 3, Lys74Arg	Russian population from Novosibirsk	Predisposition to TBE in Russian population [Barkhash AV et al. 2016]
IFNL3	interferon lambda 3	282617	IL28B	rs12980275	[Barkhash AV et al. 2016]	27068548	IFNL3, 3'-flanking region	Russian population from Novosibirsk	Predisposition to TBE in Russian population [Barkhash AV et al. 2016]

IFNL4

interferon lambda 4 (gene/pseudogene)

101180976

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	SNP ID	Reference	PMID	SNP location	Population	Phenotypic trait caused by allelic variants
IFNL4	interferon lambda 4 (gene/pseudogene)	101180976		rs12979860	[Grygorczuk S et al., 2015]	25461389	IFNL4, first intron	Polish population	IFNL3 concentration in CSF in TBE patients [Grygorczuk S et al., 2015]

IKZF2

IKAROS family zinc finger 2

22807

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IKZF2	IKAROS family zinc finger 2	22807	Helios	[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was downregulated	In vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]

IL10

interleukin 10

3586

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL10	interleukin 10	3586		[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
IL10	interleukin 10	3586		[Grygorczuk S et al., 2015]	25461389	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CSF and serum [Grygorczuk S et al., 2015]

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	SNP ID	Reference	PMID	SNP location	Population	Phenotypic trait caused by allelic variants
IL10	interleukin 10	3586		rs1800872	[Barkhash AV et al. 2016]	27068548	IL10, promoter region	Russian population from Novosibirsk	Predisposition to TBE in Russian population [Barkhash AV et al. 2016]

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	In vivo/ in vitro	Host organism	Effect	Experiment
IL10	interleukin 10	3586	IL-10	[Tun MM et al., 2014]	24938868	TBEV, Oshima strain	in vivo	mouse	Increased mortality rates [Tun MM et al., 2014]	Mice were infected subcutaneously with 104 pfu of Oshima strains and were monitored daily [Tun MM et al., 2014]

IL12A

interleukin 12A

3592

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL12A	interleukin 12A	3592		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]

IL12B

interleukin 12B

3593

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL12B	interleukin 12B	3593		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]

IL15

interleukin 15

3600

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL15	interleukin 15	3600		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]

IL16

interleukin 16

3603

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
IL16	interleukin 16	3603		[Melik W et al., 2012]	22796133	TBEV	Human	NS5 [Melik W et al., 2012]	in vitro, in vitro, PDZ array membranes [Melik W et al., 2012]

IL18

interleukin 18

3606

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL18	interleukin 18	3606		[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]

IL1A

interleukin 1 alpha

3552

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL1A	interleukin 1 alpha	3552		[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]

IL1B

interleukin 1 beta

3553

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL1B	interleukin 1 beta	3553		[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
IL1B	interleukin 1 beta	3553		[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]

IL2

interleukin 2

3558

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL2	interleukin 2	3558	[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
			[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, NK cells and plasma [Blom K et al., 2016]
			[Aberle JH et al., 2015]	26465323	TBEV	TBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)	Human	protein	Expression was downregulated	in vivo, TBEV-specific polyfunctional human CD4+ T cells [Aberle JH et al., 2015]

IL2RA

interleukin 2 receptor subunit alpha

3559

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL2RA	interleukin 2 receptor subunit alpha	3559	CD25	[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, NK cells [Krylova NV et al., 2015]
				[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, CD8 T-lymphocytes [Krylova NV et al., 2015]
				[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

IL4

interleukin 4

3565

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL4	interleukin 4	3565		[Tun MM et al., 2014]	24938868	TBEV, Oshima strain, Sofjin strain	TBEV	Mouse	mRNA	Expression was downregulated	In vivo, spleen [Tun MM et al., 2014]

IL5

interleukin 5

3567

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL5	interleukin 5	3567		[Gomez I et al., 2003]	14583154	TBEV (vaccine against TBE)	E protein (trancated)	Human	protein	Expression was upregulated	in vivo, CD4+ T lymphocytes specific for E protein from healthy blood donors vaccinated against TBEV with FSME®-IMMUN Inject (Baxter IMMUNO, Austria) [Gomez I et al., 2003]

IL6

interleukin 6

3569

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL6	interleukin 6	3569	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
			[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
			[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, plasma [Blom K et al., 2016]
			[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

IL7R

interleukin 7 receptor

3575

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IL7R	interleukin 7 receptor	3575	CD127	[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]

IRF1

interferon regulatory factor 1

3659

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IRF1	interferon regulatory factor 1	3659		[Robertson SJ et al., 2014]	24532583	TBEV (Sofjin strain)	TBEV	Mouse	protein	Expression was downregulated	in vitro, bone-marrow derived dendritic cells [Robertson SJ et al., 2014]

IRF3

interferon regulatory factor 3

3661

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
IRF3	interferon regulatory factor 3	3661		[Zhang X et al., 2016]	27576490	TBEV, Far Eastern strain	TBEV	Human	protein (phosphorylated)	Phosphorilation was upregulated	in vitro: Human T98G cells [Zhang X et al., 2016]

ITGA3

integrin subunit alpha 3

3675

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
ITGA3	integrin subunit alpha 3	3675	210 kD polypeptide, alpha 3-chain of human integrin	[Protopopova EV et al., 1997]	9499239	TBEV	Human	TBEV virion [Protopopova EV et al., 1997]	in vitro, human embryonic renal cells, affinity chromatography with polyclonal antiidiotypic antibodies (AIA) as antireceptor antibodies [Protopopova EV et al., 1997]

ITGAM

integrin subunit alpha M

3684

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
ITGAM	integrin subunit alpha M	3684	CD11b	[Krylova NV et al., 2015]	25695407	TBEV (Dal’negorsk strain)	TBEV	Human	protein	Expression was downregulated	in vitro, monocytes [Krylova NV et al., 2015]
ITGAM	integrin subunit alpha M	3684	CD11b	[Krylova NV et al., 2015]	25695407	TBEV (Primorye-183 strain)	TBEV	Human	protein	Expression was upregulated	in vitro, monocytes, granulocytes, and NK cells [Krylova NV et al., 2015]

ITGB3

integrin subunit beta 3

3690

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
ITGB3	integrin subunit beta 3	3690	αVβ3–integrin	[Zaitsev BN et al., 2014]	25319621	TBEV	Human	E protein [Zaitsev BN et al., 2014],	in vitro, enzyme immunoassay and optical surface waves-based biosensor measurements [Zaitsev BN et al., 2014]

JAG1

jagged 1

182

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
JAG1	jagged 1	182		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

KAT5

lysine acetyltransferase 5

10524

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
KAT5	lysine acetyltransferase 5	10524		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

LAMB1

laminin subunit beta 1

3912

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
LAMB1	laminin subunit beta 1	3912	beta 1-chain of human integrin (110 kD)	[Protopopova EV et al., 1997]	9499239	TBEV	Human	TBEV virion [Protopopova EV et al., 1997]	in vitro, human embryonic renal cells, affinity chromatography with polyclonal antiidiotypic antibodies (AIA) as antireceptor antibodies [Protopopova EV et al., 1997]

LAMB2

laminin subunit beta 2

3913

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
LAMB2	laminin subunit beta 2	3913		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

LILRA4

leukocyte immunoglobulin like receptor A4

23547

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
LILRA4	leukocyte immunoglobulin like receptor A4	23547	ILT7	[Dillmann C et al., 2016]	26783340	TBEV (FSME-IMMUN -inactivated whole virus vaccine against TBE)	FSME-IMMUN -inactivated whole virus vaccine against TBE	Human	protein (cell surface)	Expression was downregulated	in vitro, human plasmacytoid dendritic cells (pDCs) [Dillmann C et al., 2016]

LTF

lactotransferrin

4057

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
LTF	lactotransferrin	4057		[Merzeniuk ZA et al., 2003]	12774664	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, liquor and blood of patients with tick-borne encephalitis [Merzeniuk ZA et al., 2000]

MAGI2

membrane associated guanylate kinase, WW and PDZ domain containing 2

9863

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	9863		[Ellencrona K et al., 2009]	19199833	TBEV	Human	NS5 [Ellencrona K et al., 2009]	in vitro, PDZ array membranes [Ellencrona K et al., 2009]

MAVS

mitochondrial antiviral signaling protein

57506

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	In vivo/ in vitro	Host organism	Effect	Experiment
MAVS	mitochondrial antiviral signaling protein	57506	IPS-1	[Kurhade C et al., 2016]	26819220	TBEV strain Hypr	in vivo	mouse	Decreased median survival time [Kurhade C et al., 2016]	Six- to ten-weekold mice were intraperitoneally infected with TBEV [Kurhade C et al., 2016]

MKI67

marker of proliferation Ki-67

4288

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
MKI67	marker of proliferation Ki-67	4288	Ki67	[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, human NK cells in response to TBEV infection [Blom K et al., 2016]

MLPH

melanophilin

79083

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
MLPH	melanophilin	79083		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

MMP9

matrix metallopeptidase 9

4318

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
MMP9	matrix metallopeptidase 9	4318		[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
MMP9	matrix metallopeptidase 9	4318		[Palus M et al., 2014b]	25000960	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, serum [Palus M et al., 2014b]

MYH9

myosin heavy chain 9

4627

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
MYH9	myosin heavy chain 9	4627		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

NQO1

NAD(P)H quinone dehydrogenase 1

1728

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
NQO1	NAD(P)H quinone dehydrogenase 1	1728		[Kuzmenko YV et al., 2016a]	27875810	TBEV	NS1	Human	mRNA	Expression was upregulated	in vitro, HEK 293T cells (Human Embryonic Kidney 293 transformed with large T antigen), RT-qPCR [Kuzmenko YV et al., 2016a]

OAS1

2'-5'-oligoadenylate synthetase 1

4938

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
OAS1	2'-5'-oligoadenylate synthetase 1	4938		[Yoshii K et al., 2013]	23266832	TBEV (Sofjin-HO or Oshima 5-10 strain)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Yoshii K et al., 2013]

OAS2

2'-5'-oligoadenylate synthetase 2

4939

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	SNP ID	Reference	PMID	SNP location	Population	Phenotypic trait caused by allelic variants
OAS2	2'-5'-oligoadenylate synthetase 2	4939	rs1293762	[Barkhash AV et al., 2010]	21050126	OAS2, intron 2	Russian population from Novosibirsk	The outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]
			rs15895	[Barkhash AV et al., 2010]	21050126	OAS2, 3'-UTR / exon 11, Trp720Stop	Russian population from Novosibirsk	The outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]
			rs1732778	[Barkhash AV et al., 2010]	21050126	OAS2, 3'-flanking region	Russian population from Novosibirsk	The outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]

OAS3

2'-5'-oligoadenylate synthetase 3

4040

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	SNP ID	Reference	PMID	SNP location	Population	Phenotypic trait caused by allelic variants
OAS3	2'-5'-oligoadenylate synthetase 3	4940		rs2285932	[Barkhash AV et al., 2010]	21050126	OAS3, exon 6, Ile438Ile	Russian population from Novosibirsk	The outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]
OAS3	2'-5'-oligoadenylate synthetase 3	4940		rs2072136	[Barkhash AV et al., 2010]	21050126	OAS3, exon 8, Ser567Ser	Russian population from Novosibirsk	The outcome of tickborne encephalitis virus infection in a Russian population [Barkhash AV et al., 2010]

PDCD1

programmed cell death 1

5133

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
PDCD1	programmed cell death 1	5133	PD-1	[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]

PDE4DIP

phosphodiesterase 4D interacting protein

9659

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
PDE4DIP	phosphodiesterase 4D interacting protein	9659		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

PDLIM4

PDZ and LIM domain 4

8572

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
PDLIM4	PDZ and LIM domain 4	8572		[Ellencrona K et al., 2009]	19199833	TBEV	Human	NS5 [Ellencrona K et al., 2009]	in vitro, PDZ array membranes [Ellencrona K et al., 2009]

PEPD

peptidase D

5184

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
PEPD	peptidase D	5184		[Lubick KJ et al., 2015]	26159719	TBEV	Human	NS5 [Lubick KJ et al., 2015]	In vitro, Human Embryonic Kidney 293 (HEK293) cells, Immunoblot analysis following co‐IP(immunoprecipitation) of flavivirus NS5 and PEPD‐GFP [Lubick KJ et al., 2015]

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	Other essential protein	References	PMID	Type of interaction	Virus, strain	Host organism	In vivo/in vitro
PEPD	peptidase D	5184		IFNAR1	[Lubick KJ et al., 2015]	26159719	Interaction within pathway	TBEV (strain Sofjin)	Human	in vitro, HEK293 (Human Embryonic Kidney). In vivo, human fibroblasts

PHAX

phosphorylated adaptor for RNA export

51808

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
PHAX	phosphorylated adaptor for RNA export	51808	RNUXA	[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

PHC2

polyhomeotic homolog 2

1912

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
PHC2	polyhomeotic homolog 2	1912		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

PRF1

perforin 1

5551

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
PRF1	perforin 1	5551	[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was downregulated	in vivo, human NK cells in response to TBEV infection [Blom K et al., 2016]
PRF1	perforin 1	5551	[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CD8 and CD4 T cells from TBEV infected patients [Blom K et al., 2015]
PRF1	perforin 1	5551	[Fujii Y et al., 2011]	21830901	TBEV Oshima 5-10 strain	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

PSMB10

proteasome subunit beta 10

5699

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
PSMB10	proteasome subunit beta 10	5699		[Kuzmenko YV et al., 2016b]	27239857	TBEV (Western subtype)	NS1	Human	mRNA	Expression was upregulated	in vitro, HeLa [Kuzmenko YV et al., 2016b]

PSMB8

proteasome subunit beta 8

5696

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
PSMB8	proteasome subunit beta 8	5696		[Kuzmenko YV et al., 2016b]	27239857	TBEV (Western subtype)	NS1	Human	mRNA	Expression was upregulated	in vitro, HeLa [Kuzmenko YV et al., 2016b]

RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

5879

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	Other essential protein	References	PMID	Type of interaction	Virus, strain	Host organism	In vivo/in vitro
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	5879		SCRIB	[Wigerius M et al., 2010]	20363326	Physical interactions with important protein	TBEV	Human	in vitro, PC12 cells derived from a rat pheochromocytoma, COS-7 (fibroblast-like cell lines derived from monkey kidney tissue) [Wigerius M et al., 2010].

RIMS2

regulating synaptic membrane exocytosis 2

9699

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
RIMS2	regulating synaptic membrane exocytosis 2	9699		[Ellencrona K et al., 2009]	19199833	TBEV	Human	NS5 [Ellencrona K et al., 2009]	in vitro, PDZ array membranes [Ellencrona K et al., 2009]

RNF125

ring finger protein 12

54941

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
RNF125	ring finger protein 12	54941		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

RPSA

ribosomal protein SA

3921

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
RPSA	ribosomal protein SA	3921	LBP, 67 kD laminin receptor, LamR1, laminin receptor 1	[Protopopova EV et al., 1997]	9499239	TBEV	Human	TBEV virion [Protopopova EV et al., 1997]	in vitro, human embryonic renal cells, affinity chromatography with polyclonal antiidiotypic antibodies (AIA) as antireceptor antibodies [Protopopova EV et al., 1997]
			LBP, 67 kD laminin receptor, LamR1, laminin receptor 2	[Malygin AA et al., 2009]	19961413	TBEV	Human	E protein [Malygin AA et al., 2009]	in vitro, enzyme immunoassay and immunoblotting [Malygin AA et al., 2009]
			LBP, 67 kD laminin receptor, LamR1, laminin receptor 3	[Zaitsev BN et al., 2014]	25319621	TBEV	Human	E protein [Zaitsev BN et al., 2014]	in vitro, combined methods of single-molecule dynamic force spectroscopy (SMDFS), enzyme immunoassay and optical surface waves-based biosensor measurements [Zaitsev BN et al., 2014]

RSAD2

radical S-adenosyl methionine domain containing 2

91543

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
RSAD2	radical S-adenosyl methionine domain containing 2	91543	Viperin	[Lindqvist R et al., 2016]	27776548	TBEV	TBEV	Mouse	mRNA	Expression was upregulated	in vitro, Primary astrocytes and MEFs (mouse embryonic fibroblasts) [Lindqvist R et al., 2016]

S1PR4

sphingosine-1-phosphate receptor 4

8698

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	Other essential protein	References	PMID	Type of interaction	Virus, strain	Host organism	In vivo/in vitro
S1PR4	sphingosine-1-phosphate receptor 4	8698		LILRA4	[Dillmann C et al., 2016]	26783340	Interaction within pathway	TBEV (FSME-IMMUN -inactivated whole virus vaccine against TBE)	Human	in vitro, human plasmacytoid dendritic cells (pDCs)

SCRIB

scribbled planar cell polarity protein

23513

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
SCRIB	scribbled planar cell polarity protein	23513	[Ellencrona K et al., 2009]	19199833	TBEV	Human	NS5 [Ellencrona K et al., 2009]	in vitro, PDZ array membranes [Ellencrona K et al., 2009]
			[Werme K et al., 2008]	18042258	TBEV	in vitro, yeast two-hybrid (Y2H) screen against a human brain cDNA library [Werme K et al 2008]	Human	NS5 [Werme K et al., 2008]
			[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

6598

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	6598		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

SOCS1

suppressor of cytokine signaling 1

8651

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
SOCS1	suppressor of cytokine signaling 1	8651		[Mansfield KL et al., 2010]	20854017	TBEV, strain Neudoerfl	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

SOCS3

suppressor of cytokine signaling 3

9021

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
SOCS3	suppressor of cytokine signaling 3	9021		[Mansfield KL et al., 2010]	20854017	TBEV, strain Neudoerfl	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

SPDL1

spindle apparatus coiled-coil protein 1

54908

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
SPDL1	spindle apparatus coiled-coil protein 1	54908	CCDC99	[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

TAF15

TATA-box binding protein associated factor 15

8148

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
TAF15	TATA-box binding protein associated factor 15	8148		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

TBK1

TANK binding kinase 1

29110

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
TBK1	TANK binding kinase 1	29110		[Zhang X et al., 2016]	27576490	TBEV, Far Eastern strain	TBEV	Human	protein (phosphorylated)	Phosphorilation was upregulated	in vitro: Human T98G cells [Zhang X et al., 2016]

TBX21

T-box 21

30009

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
TBX21	T-box 21	30009	Tbet, T-bet	[Aberle JH et al., 2015]	26465323	TBEV	TBEV versus formalin-inactivated TBE virus vaccine (FSME-Immun1 0.5 ml, Baxter)	Human	protein	Expression was upregulated	in vivo, TBEV-specific polyfunctional human CD4+ T cells (L-2+IFN-γ+) [Aberle JH et al., 2015]
TBX21	T-box 21	30009	Tbet, T-bet	[Blom K et al., 2015]	25611738	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, CD8 T cells from TBEV infected patients [Blom K et al., 2015]

TIA1

TIA1 cytotoxic granule associated RNA binding protein

7072

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
TIA1	TIA1 cytotoxic granule associated RNA binding protein	7072		[Albornoz A et al., 2014]	24696465	TBEV	Human	RNA [Albornoz A et al., 2014]	in vitro, human U2OS (Human Bone Osteosarcoma Epithelial Cells) cells, Immunofluorescence, and immunoblot analyses [Albornoz A et al., 2014]

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	In vivo/ in vitro	Host organism	Effect	Experiment
TIA1	TIA1 cytotoxic granule associated RNA binding protein	7072	TIA-1	[Albornoz A et al., 2014]	24696465	TBEV, strain Neudoerfl	in vitro, mouse embryonic fibroblast (MEF)	mouse	Increase in TBEV extracellular infectivity [Albornoz A et al., 2014]	MEF TIA-1−/− or their control (MEF WT) were infected with TBEV at an MOI of 2. Cell supernatant collected 24 and 48 h p.i. was used to infect Vero cells to measure virus yields (PFU/ml) from infected MEF TIA-1−/− or infected MEF WT samples

TIAL1

TIA1 cytotoxic granule associated RNA binding protein like 1

7073

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
TIAL1	TIA1 cytotoxic granule associated RNA binding protein like 1	7073	TIAR	[Albornoz A et al., 2014]	24696465	TBEV	Human	RNA [Albornoz A et al., 2014]	in vitro, human U2OS (Human Bone Osteosarcoma Epithelial Cells) cells, Immunofluorescence, and immunoblot analyses [Albornoz A et al., 2014]

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	In vivo/ in vitro	Host organism	Effect	Experiment
TIAL1	TIA1 cytotoxic granule associated RNA binding protein like 1	7073	TIAR	[Albornoz A et al., 2014]	24696465	TBEV, strain Neudoerfl	in vitro, mouse embryonic fibroblast (MEF)	mouse	Decrease in TBEV extracellular infectivity [Albornoz A et al., 2014]	MEF TIAR−/− or their control (MEF WT) were infected with TBEV at an MOI of 2. Cell supernatant collected 24 and 48 h p.i. was used to infect Vero cells to measure virus yields (PFU/ml) from infected MEF TIAR−/− or infected MEF WT samples

TJP1

tight junction protein 1

7082

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
TJP1	tight junction protein 1	7082		[Ellencrona K et al., 2009]	19199833	TBEV	Human	NS5 [Ellencrona K et al., 2009]	in vitro, PDZ array membranes, immunochemical analysis, HeLa and MDCK cells [Ellencrona K et al., 2009]

TJP2

tight junction protein 2

9414

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
TJP2	tight junction protein 2	9414		[Melik W et al., 2012]	22796133	TBEV	Human	NS5 [Melik W et al., 2012]	in vitro, in vitro, PDZ array membranes [Melik W et al., 2012]

TLR3

toll like receptor 3

7098

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	SNP ID	Reference	PMID	SNP location	Population	Phenotypic trait caused by allelic variants
TLR3	toll like receptor 3	7098		rs3775291	[Mickienė A et al., 2014], [Barkhash AV et al., 2013]	25226020, 23721942	TLR3, exon 4, Leu412Phe	Russian population from Novosibirsk, Lithuanian Population	Disease severity in adult [Mickienė A et al., 2014]

TLR7

toll like receptor 7

51284

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
TLR7	toll like receptor 7	51284		[Dillmann C et al., 2016]	26783340	TBEV (FSME-IMMUN -inactivated whole virus vaccine against TBE)	Human	FSME-IMMUN -inactivated whole virus vaccine against TBE [Dillmann C et al., 2016]	in vitro, human plasmacytoid dendritic cells (pDCs) [Dillmann C et al., 2016]

TNF

tumor necrosis factor

7124

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
TNF	tumor necrosis factor	7124	tumour necrosis factor α	[Palus M et al., 2014a]	25000960	TBEV (strain Neudoerfl)	TBEV	Human	mRNA	Expression was upregulated	in vitro, primary human brain cortex astrocytes (HBCA), real-time RT-PCR. [Palus M et al., 2014]
				[Palus M et al., 2013]	23805778	TBEV ( strain Neudoerfl)	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, mouse (BALB/c) brain, Real-time quantitative PCR [Palus M et al., 2013]
				[Blom K et al., 2016]	27543616	TBEV	TBEV	Human	protein	Expression was upregulated	in vivo, plasma [Blom K et al., 2016]
TNF	tumor necrosis factor	7124	TNFa	[Růžek D et al., 2011]	21629771	TBEV, strain Neudoerfl/IRE	TBEV	Mouse	mRNA	Expression was upregulated	in vivo, brain [Fujii Y et al., 2011]

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	In vivo/ in vitro	Host organism	Effect	Experiment
TNF	tumor necrosis factor	7124	TNF-a	[Tun MM et al., 2014]	24938868	TBEV, Oshima strain	in vivo	mouse	Increased mortality rates [Tun MM et al., 2014]	Mice were infected subcutaneously with 104 pfu of Oshima strains and were monitored daily [Tun MM et al., 2014]

TOM1L1

target of myb1 like 1 membrane trafficking protein

10040

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
TOM1L1	target of myb1 like 1 membrane trafficking protein	10040		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

TRIM21

tripartite motif containing 21

6737

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
TRIM21	tripartite motif containing 21	6737		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

TXNDC9

thioredoxin domain containing 9

10190

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
TXNDC9	thioredoxin domain containing 9	10190		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

TYK2

tyrosine kinase 2

7297

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
TYK2	tyrosine kinase 2	7297		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

VIM

vimentin

7431

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
VIM	vimentin	7431		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

VPS11

VPS11, CORVET/HOPS core subunit

55823

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
VPS11	VPS11, CORVET/HOPS core subunit	55823		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

XBP1

X-box binding protein 1

7424

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Inductor (TBEV or protein)	Host organism	mRNA expression level or protein expression level	Effect	Method in vivo/invitro
XBP1	X-box binding protein 1	7494	sXBP1	[Yu C. et al., 2013]	24177270	TBEV (strain K23)	TBEV	African Green Monkey	mRNA, protein	Expression was upregulated	in vitro, Vero E6 (Monkey African Green kidney A subclone of Vero76) cells, A550 [Yu C. et al., 2013]

ZBTB17

zinc finger and BTB domain containing 17

7709

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
ZBTB17	zinc finger and BTB domain containing 17	7709		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]

ZCCHC17

zinc finger CCHC-type containing 17

51538

EntrezGene Official Symbol	Official Full Name	EntrezGene Gene ID	Also known as	References	PMID	Virus, strain	Host organism	Interactant: TBEV virion or viral proten or viral RNA	Method
ZCCHC17	zinc finger CCHC-type containing 17	51538		[Le Breton M et al., 2011]	22014111	TBEV (strain 263)	Human	NS5 [Le Breton M et al., 2011]	in vitro, high-throughput yeast two-hybrid screen using human cDNA libraries from liver, brain, spleen and bronchial epithelia [Le Breton M et al., 2011]