- Department of Medical Biology and Biotechnology at Far Eastern Federal University (FEFU)
In collaboration with colleagues from FEFU, we perform investigation of the molecular mechanisms underlying regulation of behavior and physiological functions in the brain using advanced microscopic analysis methods, including a unique multiphoton microscopy system that allows us to analyze cellular processes in the mouse brain in vivo. We also utilize confocal microscopy to perform FRET analysis, that allows identification of protein-protein interactions on the surface of neurons.
- Institute of Biomedical Problems RAS (Moscow)
In the collaboration with Institute of Biomedical Problems RAS we are studying the effect of prolonged spaceflight (30 days on board of the Russian biosatellite BION-M2) on the expression of neurogenes in mice. The attention was focused on investigation of key genes of the brain dopamine system and genes encoding brain neurotrophic factors and their receptors.
- Institute of Cellular Neurophysiology (Hannover, Germany)
In the collaboration with Institute of Cellular Neurophysiology (Hannover, Germany) we have been studied the role of posttranslational palmitoylation of serotonin 5-HT1A receptors in the regulation of this receptor function. This scientific direction was developed in Hannover mainly on cellular level. In our Laboratory we have been investigated the role of palmitoylation of serotonin 5-HT1A in the regulation of depressive-like behavior.
- Institute of Physiology SD RAMS (Novosibirsk)
In the collaboration with of the Group of Cognitive Neurolinguistics, Institute of physiology SD RAMS, we have been studied the neurophysiological and molecular genetic indicators for realization of psychological and emotional personality traits in people of different ethnic groups. Together with the Laboratory of Physiology of Cognitive Activity we have been investigated the associations between polymorphisms in genes encoding key elements of the brain serotonin system, and the phenotypic characteristics of cognitive and emotional functions. The obtained results contribute to the understanding of the mechanisms of effects of genetically determined serotonin metabolism features on the processes of emotional and cognitive processes interaction.
- Institute of Automation and Electrometry SD RAS (Novosibirsk)
In the Institute of Automation and Electrometry SD RAS together with our Laboratory the System for Ethological Tests Automation “EthoStudio” was elaborated. In our Laboratory using this system the behavior of different animal species is testing (e.g. mice, rats, pigs). This equipment is installed in Conventional and in SPF vivariums of ICG. Our laboratory helps to improve the program for the needs of biologists.
- Institute of Organic Chemistry SD RAS (Novosibirsk)
In this Institute the original psychotropic drug TK-2153, a STEP phosphatase inhibitor, was synthesized. In our Laboratory it was shown that TK-2153 exerts antidepressive and anticataleptic features and affects the brain serotonin system and neurotrophic factor. Study on the role of the STEP phosphatase in the regulation of behavior continues within the Psychoneuropharmacology Sector, established within our laboratory.
- Laboratory of Evolutionary Genetics (Institute of Cytology and Genetics, Novosibirsk)
Together with Laboratory of Evolutionary Genetics we investigate the implication of serotonergic and dopaminergic neurotransmitter systems as well as different neurotrophic factors and their receptors in the regulation of genetically determined predisposition to aggressive behavior. We also study the role of transcriptional regulation of serotonin 5-HT1A receptors in the regulation of aggressive behavior.
- Laboratory of Molecular Mechanisms of Aging (Institute of Cytology and Genetics SB RAS, Novosibirsk)
Together with the Laboratory of Molecular Mechanisms of Aging at the Institute of Cytology and Genetics SB RAS, we investigate the role of serotonin receptors in the mechanisms of pathological protein aggregation in Alzheimer’s disease in OXYS rats. The possibilities of using neurotrophic factors for the treatment of Alzheimer’s disease are being studied as well.