Spinal motor neurons (MNs) are a highly specialized type of neurons that reside in the ventral horns and project axons to muscles to control their movement. Degeneration of MNs is implicated in a number of…
The study of neurodegenerative diseases such as Parkinson’s disease has long been hampered by the lack of models that accurately reproduce human brain cells in vitro. iPSC-differentiated dopaminergic neurons carry the same genetic signature as…
iPSC-derived medium spiny neurons (MSNs) is a cellular model to study neurodegeneration in Huntington’s disease. This model allows to study molecular mechanisms of the disease, large-scale drug screening, and toxicological studies. We generate MSNs from…