Isogenic HD modelHuntington’s disease (HD) is a severe neurodegenerative disorder caused by a CAG triplet expansion in the first exon of the HTT gene. Here we generated isogenic iPSC-based HD model by introducing 69 CAG…
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by death of motor neurons. To date, neither etiology nor pathogenesis of ALS is clear, which leads to the absence of an effective treatment strategy. Animal…
Hypoxia-inducible factors (HIFs) are transcription factors that play an important role in the adaptive response to hypoxic conditions. HIFs are stabilized in hypoxia but degraded in normoxia. HIF-2α subunit is involved in the regulation of…